Search Results - "Wittig, I."

Ubiquitylome profiling of Parkin-null brain reveals dysregulation of calcium homeostasis factors ATP1A2, Hippocalcin and GNA11, reflected by altered firing of noradrenergic neurons by Key, J., Mueller, A.K., Gispert, S., Matschke, L., Wittig, I., Corti, O., Münch, C., Decher, N., Auburger, G.

“…Parkinson's disease (PD) is the second most frequent neurodegenerative disorder in the old population. Among its monogenic variants, a frequent cause is a…”
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Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors by Gispert, Suzana, Parganlija, Dajana, Klinkenberg, Michael, Dröse, Stefan, Wittig, Ilka, Mittelbronn, Michel, Grzmil, Pawel, Koob, Sebastian, Hamann, Andrea, Walter, Michael, Büchel, Finja, Adler, Thure, Hrabé de Angelis, Martin, Busch, Dirk H, Zell, Andreas, Reichert, Andreas S, Brandt, Ulrich, Osiewacz, Heinz D, Jendrach, Marina, Auburger, Georg

“…The caseinolytic peptidase P (CLPP) is conserved from bacteria to humans. In the mitochondrial matrix, it multimerizes and forms a macromolecular…”
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Imbalances in protein homeostasis caused by mutant desmin by Winter, L., Unger, A., Berwanger, C., Spörrer, M., Türk, M., Chevessier, F., Strucksberg, K.‐H., Schlötzer‐Schrehardt, U., Wittig, I., Goldmann, W. H., Marcus, K., Linke, W. A., Clemen, C. S., Schröder, R.

“…Aims We investigated newly generated immortalized heterozygous and homozygous R349P desmin knock‐in myoblasts in conjunction with the corresponding…”
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Nuclear eNOS interacts with and S-nitrosates ADAR1 to modulate endothelial gene expression by Zhou, X, Guenther, S, Kuenne, K, Wittig, I, Fleming, I, Siragusa, M

“…Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Collaborative Research Centre (CRC 1366); Chinese Scholarship…”
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M.P.1.04 A novel mtDNA mutation in COIII impairs assembly of cytochrome c oxidase in a MELAS patient by Tessa, A, Pennisi, E, Cassandrini, D, Rizza, T, Wittig, I, Fattori, F, Meschini, M, Bertini, E, Santarelli, L, Bruno, C, Carrozzo, R, Schägger, H, Santorelli, F

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The novel ageing-induced long non-coding RNA MIRIAL controls endothelial cell and mitochondrial function by Kohnle, C, Theodorou, K, Koziarek, S, Sommer, J, Busscher, D, Wagner, J U G, Wittig, I, Dimmeler, S, Boon, R A

“…Abstract   Vascular ageing is a key risk factor for cardiovascular diseases and is characterised by a continuous decline in endothelial cell function. Despite…”
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Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function by Leisegang, Matthias S, Fork, Christian, Josipovic, Ivana, Richter, Florian Martin, Preussner, Jens, Hu, Jiong, Miller, Matthew J, Epah, Jeremy, Hofmann, Patrick, Günther, Stefan, Moll, Franziska, Valasarajan, Chanil, Heidler, Juliana, Ponomareva, Yuliya, Freiman, Thomas M, Maegdefessel, Lars, Plate, Karl H, Mittelbronn, Michel, Uchida, Shizuka, Künne, Carsten, Stellos, Konstantinos, Schermuly, Ralph T, Weissmann, Norbert, Devraj, Kavi, Wittig, Ilka, Boon, Reinier A, Dimmeler, Stefanie, Pullamsetti, Soni Savai, Looso, Mario, Miller, Francis J, Brandes, Ralf P

“…BACKGROUND:The angiogenic function of endothelial cells is regulated by numerous mechanisms, but the impact of long noncoding RNAs (lncRNAs) has hardly been…”
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The novel ageing-induced long non-coding RNA MIRIAL controls endothelial cell and mitochondrial function by Kohnle, C, Theodorou, K, Koziarek, S, Busscher, D, Sommer, J, Wagner, J U G, Wittig, I, Dimmeler, S, Boon, R A

“…Abstract   Vascular ageing is a key risk factor for cardiovascular diseases and is characterised by a continuous decline in endothelial function. Despite…”
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Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation by Leuner, Kristina, Schütt, Tanja, Kurz, Christopher, Eckert, Schamim H, Schiller, Carola, Occhipinti, Angelo, Mai, Sören, Jendrach, Marina, Eckert, Gunter P, Kruse, Shane E, Palmiter, Richard D, Brandt, Ulrich, Dröse, Stephan, Wittig, Ilka, Willem, Michael, Haass, Christian, Reichert, Andreas S, Müller, Walter E

“…Intracellular amyloid beta (Aβ) oligomers and extracellular Aβ plaques are key players in the progression of sporadic Alzheimer's disease (AD). Still, the…”
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Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression by Winter, Hanna, Winski, Greg, Busch, Albert, Chernogubova, Ekaterina, Fasolo, Francesca, Wu, Zhiyuan, Bäcklund, Alexandra, Khomtchouk, Bohdan B., Van Booven, Derek J., Sachs, Nadja, Eckstein, Hans-Henning, Wittig, Ilka, Boon, Reinier A., Jin, Hong, Maegdefessel, Lars

“…Long non-coding RNAs (lncRNAs) orchestrate various biological processes and regulate the development of cardiovascular diseases. Their potential therapeutic…”
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Thrombotic thrombocytopenic purpura : MRI demonstration of persistent small cerebral infarcts after clinical recovery by GRUBER, O, WITTIG, I, WIGGINS, C. J, VON CRAMON, D. Y

“…Abnormalities in the brain of patients with thrombotic thrombocytopenic purpura (TTP) are infrequent on MRI, often reversible and mainly limited to symptomatic…”
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Long non-coding RNA MEG8 induces endothelial barrier through regulation of microRNA-370 and -494 processing by Kremer, Veerle, Stanicek, Laura, van Ingen, Eva, Bink, Diewertje I, Hilderink, Sarah, Tijsen, Anke J, Wittig, Ilka, Mägdefessel, Lars, Nossent, Anne Yaël, Boon, Reinier A

“…The 14q32 locus is an imprinted region in the human genome which contains multiple non-coding RNAs. We investigated the role of Maternally Expressed Gene 8…”
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P564L-cystathionine metabolism by cystathionine gamma lyase generates H2S to preserve endothelial cell function and decelerate atherosclerosis development in humans by Bibli, S I, Hu, J, Randriamboavonjy, V, Siragusa, M, Sigala, F, Zukunft, S, Pfeilschifter, J, Wittig, I, Papapetropoulos, A, Fleming, I

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Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2 by Oo, James A., Pálfi, Katalin, Warwick, Timothy, Wittig, Ilka, Prieto-Garcia, Cristian, Matkovic, Vigor, Tomašković, Ines, Boos, Frederike, Izquierdo Ponce, Judit, Teichmann, Tom, Petriukov, Kirill, Haydar, Shaza, Maegdefessel, Lars, Wu, Zhiyuan, Pham, Minh Duc, Krishnan, Jaya, Baker, Andrew H., Günther, Stefan, Ulrich, Helle D., Dikic, Ivan, Leisegang, Matthias S., Brandes, Ralf P.

“…In healthy vessels, endothelial cells maintain a stable, differentiated, and growth-arrested phenotype for years. Upon injury, a rapid phenotypic switch…”
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Serological evidence of Chlamydia pneumoniae lipopolysaccharide antibodies in atherosclerosis of various vascular regions by Körner, I, Blatz, R, Wittig, I, Pfeiffer, D, Rühlmann, C

“…The role of Chlamydia pneumoniae in the pathogenesis of atherosclerosis has so far mainly been investigated in patients suffering from coronary heart disease;…”
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Donor site morbidity after microvascular medial femoral condylar flap procurement for facial reconstruction by Zeman-Kuhnert, K., Gaggl, A.J., Brandtner, C., Wittig-Draenert, A.I., Bottini, G.B., Wittig, J.

“…The medial femoral condyle (MFC) flap is considered an ideal graft for bone reconstructions. This study was performed to evaluate donor site knee joint…”
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CRISPR/Cas9-mediated knockout of RTN4IP1 leads to a severe Complex I assembly defect by Oláhová, M., Collier, J., Heidler, J., Thompson, K., Lightowlers, R.N., Chrzanowska-Lightowlers, Z.M.A., Wittig, I., Taylor, R.W.

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M10 - CRISPR/Cas9-mediated knockout of RTN4IP1 leads to a severe Complex I assembly defect by Oláhová, M., Collier, J., Heidler, J., Thompson, K., Lightowlers, R.N., Chrzanowska-Lightowlers, Z.M.A., Wittig, I., Taylor, R.W.

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Sequence variations in the NDUFA1 gene encoding a subunit of complex I of the respiratory chain by Wittig, I., Augstein, P., Brown, G. K., Fujii, T., Rötig, A., Rustin, P., Munnich, A., Seibel, P., Thorburn, D., Wissinger, B., Tamboom, K., Metspalu, A., Lamantea, E., Zeviani, M., Wehnert, M. S.

“…NDUFA1 is one of the 36 nuclear genes encoding subunits of the mitochondrial complex I involved in the respiratory chain. The human NDUFA1 has been cloned,…”
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Genomic organization of the human complex I 13-kDa subunit gene NDUFA5 by Tensing, K, Pata, I, Wittig, I, Wehnert, M, Metspalu, A

“…We have characterized the human gene NDUFA5 encoding a 13-kDa subunit of the mitochondrial respiratory chain complex I (NADH: ubiquinone oxidoreductase). The…”
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