Search Results - "Wittgen, Hanneke G M"

Cannabinoid Type 1 Receptor Antagonists Modulate Transport Activity of Multidrug Resistance-Associated Proteins MRP1, MRP2, MRP3, and MRP4 by WITTGEN, Hanneke G. M, VAN DEN HEUVEL, Jeroen J. M. W, VAN DEN BROEK, Petra H. H, DINTER-HEIDORN, Heike, KOENDERINK, Jan B, RUSSEL, Frans G. M

“…Cannabinoid type 1 (CB1) receptor antagonists have been developed for the treatment of obesity, but a major disadvantage is that they cause unwanted…”
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Exploiting Transport Activity of P-Glycoprotein at the Blood–Brain Barrier for the Development of Peripheral Cannabinoid Type 1 Receptor Antagonists by Wittgen, Hanneke G. M, Greupink, Rick, van den Heuvel, Jeroen J. M. W, van den Broek, Petra H. H, Dinter-Heidorn, Heike, Koenderink, Jan B, Russel, Frans G. M

“…Although the CB1 receptor antagonist/inverse agonist rimonabant has positive effects on weight loss and cardiometabolic risk factors, neuropsychiatric side…”
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Conditional fast expression and function of multimeric TRPV5 channels using Shield-1 by Schoeber, Joost P H, van de Graaf, Stan F J, Lee, Kyu Pil, Wittgen, Hanneke G M, Hoenderop, Joost G J, Bindels, René J M

“…A recently described novel controllable method to regulate protein expression is based on a mutated FK506-binding protein-12 (mtFKBP) that is unstable and…”
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Reactive oxygen species in melanoma and its therapeutic implications by Wittgen, Hanneke G M, van Kempen, Léon C L T

“…Oxidative phosphorylation in the mitochondria is an important energy-producing process for eukaryotic cells, but this process can also result in producing…”
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Interaction of digitalis-like compounds with p-glycoprotein by Gozalpour, Elnaz, Wittgen, Hanneke G M, van den Heuvel, Jeroen J M W, Greupink, Rick, Russel, Frans G M, Koenderink, Jan B

“…Digitalis-like compounds (DLCs), or cardiac glycosides, are produced and sequestered by certain plants and animals as a protective mechanism against herbivores…”
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Phenylalanine 368 of multidrug resistance-associated protein 4 (MRP4/ABCC4) plays a crucial role in substrate-specific transport activity by Wittgen, Hanneke G.M., van den Heuvel, Jeroen J.M.W., Krieger, Elmar, Schaftenaar, Gijs, Russel, Frans G.M., Koenderink, Jan B.

“…Multidrug resistance-associated protein 4 (MRP4) is a membrane transporter that mediates the cellular efflux of a wide range of anionic drugs and endogenous…”
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Transport of the coumarin metabolite 7-hydroxycoumarin glucuronide is mediated via multidrug resistance-associated proteins 3 and 4 by Wittgen, Hanneke G M, van den Heuvel, Jeroen J M W, van den Broek, Petra H H, Siissalo, Sanna, Groothuis, Geny M M, de Graaf, Inge A M, Koenderink, Jan B, Russel, Frans G M

“…Coumarin (1,2-benzopyrone) is a natural compound that has been used as a fragrance in the food and perfume industry and could have therapeutic usefulness in…”
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