Search Results - "Witters, Lee A."

The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases by Hurley, Rebecca L., Anderson, Kristin A., Franzone, Jeanne M., Kemp, Bruce E., Means, Anthony R., Witters, Lee A.

“…The AMP-activated protein kinase (AMPK) is an important regulator of cellular metabolism in response to metabolic stress and to other regulatory signals. AMPK…”
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Hypothalamic CaMKK2 Contributes to the Regulation of Energy Balance by Anderson, Kristin A., Ribar, Thomas J., Lin, Fumin, Noeldner, Pamela K., Green, Michelle F., Muehlbauer, Michael J., Witters, Lee A., Kemp, Bruce E., Means, Anthony R.

“…Detailed knowledge of the pathways by which ghrelin and leptin signal to AMPK in hypothalamic neurons and lead to regulation of appetite and glucose…”
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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex by Brugarolas, James, Lei, Kui, Hurley, Rebecca L, Manning, Brendan D, Reiling, Jan H, Hafen, Ernst, Witters, Lee A, Ellisen, Leif W, Kaelin, Jr, William G

“…Mammalian target of rapamycin (mTOR) is a central regulator of protein synthesis whose activity is modulated by a variety of signals. Energy depletion and…”
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The Tumor Suppressor LKB1 Kinase Directly Activates AMP-Activated Kinase and Regulates Apoptosis in Response to Energy Stress by Shaw, Reuben J., Kosmatka, Monica, Bardeesy, Nabeel, Hurley, Rebecca L., Witters, Lee A., DePinho, Ronald A., Cantley, Lewis C.

“…AMP-activated protein kinase (AMPK) is a highly conserved sensor of cellular energy status found in all eukaryotic cells. AMPK is activated by stimuli that…”
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Regulation of AMP-activated Protein Kinase by Multisite Phosphorylation in Response to Agents That Elevate Cellular cAMP by Hurley, Rebecca L., Barré, Laura K., Wood, Sumintra D., Anderson, Kristin A., Kemp, Bruce E., Means, Anthony R., Witters, Lee A.

“…The AMP-activated protein kinase (AMPK) and cAMP signaling systems are both key regulators of cellular metabolism. In this study, we show that AMPK activity is…”
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AMP‐activated protein kinase counteracts brain‐derived neurotrophic factor‐induced mammalian target of rapamycin complex 1 signaling in neurons by Ishizuka, Yuta, Kakiya, Naomasa, Witters, Lee A., Oshiro, Noriko, Shirao, Tomoaki, Nawa, Hiroyuki, Takei, Nobuyuki

“…Growth factors and nutrients, such as amino acids and glucose, regulate mammalian target of rapamycin complex 1 (mTORC1) signaling and subsequent translational…”
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AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis by Vadász, István, Dada, Laura A, Briva, Arturo, Trejo, Humberto E, Welch, Lynn C, Chen, Jiwang, Tóth, Péter T, Lecuona, Emilia, Witters, Lee A, Schumacker, Paul T, Chandel, Navdeep S, Seeger, Werner, Sznajder, Jacob I

“…Hypercapnia (elevated CO(2) levels) occurs as a consequence of poor alveolar ventilation and impairs alveolar fluid reabsorption (AFR) by promoting Na,K-ATPase…”
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Effect of Exercise Intensity on Skeletal Muscle AMPK Signaling in Humans by CHEN, Zhi-Ping, STEPHENS, Terry J, MURTHY, Sid, CANNY, Benedict J, HARGREAVES, Mark, WITTERS, Lee A, KEMP, Bruce E, MCCONELL, Glenn K

“…Effect of Exercise Intensity on Skeletal Muscle AMPK Signaling in Humans Zhi-Ping Chen 1 , Terry J. Stephens 2 , Sid Murthy 1 , Benedict J. Canny 2 , Mark…”
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Silencing the constitutive active transcription factor CREB by the LKB1‐SIK signaling cascade by Katoh, Yoshiko, Takemori, Hiroshi, Lin, Xing‐zi, Tamura, Mitsuhiro, Muraoka, Masaaki, Satoh, Tomohiro, Tsuchiya, Yuko, Min, Li, Doi, Junko, Miyauchi, Akira, Witters, Lee A., Nakamura, Haruki, Okamoto, Mitsuhiro

“…Cyclic AMP responsive element (CRE)‐binding protein (CREB) is known to activate transcription when its Ser133 is phosphorylated. Two independent investigations…”
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Malonyl-CoA, fuel sensing, and insulin resistance by Ruderman, N B, Saha, A K, Vavvas, D, Witters, L A

“…Malonyl-CoA is an allosteric inhibitor of carnitine palmitoyltransferase (CPT) I, the enzyme that controls the transfer of long-chain fatty acyl (LCFA)-CoAs…”
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AMP-activated protein kinase activity and glucose uptake in rat skeletal muscle by Musi, N, Hayashi, T, Fujii, N, Hirshman, M F, Witters, L A, Goodyear, L J

“…The AMP-activated protein kinase (AMPK) has been hypothesized to mediate contraction and 5-aminoimidazole-4-carboxamide 1-beta-D-ribonucleoside (AICAR)-induced…”
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Genetic model for the chronic activation of skeletal muscle AMP-activated protein kinase leads to glycogen accumulation by Barré, Laura, Richardson, Christine, Hirshman, Michael F, Brozinick, Joseph, Fiering, Steven, Kemp, Bruce E, Goodyear, Laurie J, Witters, Lee A

“…The AMP-activated protein kinase (AMPK) is an important metabolic sensor/effector that coordinates many of the changes in mammalian tissues during variations…”
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Dual Mechanisms Regulating AMPK Kinase Action in the Ischemic Heart by Baron, Suzanne J, Li, Ji, Russell, Raymond R, Neumann, Dietbert, Miller, Edward J, Tuerk, Roland, Wallimann, Theo, Hurley, Rebecca L, Witters, Lee A, Young, Lawrence H

“…AMP-activated protein kinase (AMPK) is emerging as an important signaling protein during myocardial ischemia. AMPK is a heterotrimeric complex containing an α…”
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Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells by Hallows, Kenneth R, Kobinger, Gary P, Wilson, James M, Witters, Lee A, Foskett, J Kevin

“…The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated, ATP-gated Cl(-) channel and cellular conductance regulator, but the…”
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Insulin-like growth factor 1 is essential for normal dendritic growth by Cheng, Clara M., Mervis, Ronald F., Niu, Shui-Lin, Salem Jr, Norman, Witters, Lee A., Tseng, Victor, Reinhardt, Rickey, Bondy, Carolyn A.

“…This study evaluated somatic and dendritic growth of neurons in the frontoparietal cortex of Igf1–/– brains. Pyramidal neuron density was increased by ∼25% (P…”
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Regulation of Channel Gating by AMP-activated Protein Kinase Modulates Cystic Fibrosis Transmembrane Conductance Regulator Activity in Lung Submucosal Cells by Hallows, Kenneth R., McCane, Jill E., Kemp, Bruce E., Witters, Lee A., Foskett, J. Kevin

“…Cystic fibrosis transmembrane conductance regulator (CFTR) Cl−channel activity is important for fluid and electrolyte transport in many epithelia including the…”
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C75, a Fatty Acid Synthase Inhibitor, Modulates AMP-activated Protein Kinase to Alter Neuronal Energy Metabolism by Landree, Leslie E, Hanlon, Andrea L, Strong, David W, Rumbaugh, Gavin, Miller, Ian M, Thupari, Jagan N, Connolly, Erin C, Huganir, Richard L, Richardson, Christine, Witters, Lee A, Kuhajda, Francis P, Ronnett, Gabriele V

“…C75, a synthetic inhibitor of fatty acid synthase (FAS), is hypothesized to alter the metabolism of neurons in the hypothalamus that regulate feeding behavior…”
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Up-regulation of AMP-activated Kinase by Dysfunctional Cystic Fibrosis Transmembrane Conductance Regulator in Cystic Fibrosis Airway Epithelial Cells Mitigates Excessive Inflammation by Hallows, Kenneth R., Fitch, Adam C., Richardson, Christine A., Reynolds, Paul R., Clancy, John P., Dagher, Pierre C., Witters, Lee A., Kolls, Jay K., Pilewski, Joseph M.

“…AMP-activated kinase (AMPK) is a ubiquitous metabolic sensor that inhibits the cystic fibrosis (CF) transmembrane conductance regulator (CFTR). To determine…”
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Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment by Kim, Eun-Kyoung, Miller, Ian, Landree, Leslie E, Borisy-Rudin, Felice F, Brown, Pierre, Tihan, Tarik, Townsend, Craig A, Witters, Lee A, Moran, Timothy H, Kuhajda, Francis P, Ronnett, Gabriele V

“…We previously demonstrated that C75, a specific and potent inhibitor of fatty acid synthase (FAS), reduced food intake and decreased body weight in mice. In…”
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The Role of AMPK and mTOR in Nutrient Sensing in Pancreatic β-Cells by Gleason, Catherine E., Lu, Danhong, Witters, Lee A., Newgard, Christopher B., Birnbaum, Morris J.

“…The AMP-activated protein kinase (AMPK) is a central regulator of the energy status of the cell, based on its unique ability to respond directly to…”
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