Search Results - "Witters, L.A."

AMP-activated protein kinase, super metabolic regulator by Kemp, B E, Stapleton, D, Campbell, D J, Chen, Z-P, Murthy, S, Walter, M, Gupta, A, Adams, J J, Katsis, F, van Denderen, B, Jennings, I G, Iseli, T, Michell, B J, Witters, L A

“…The AMP-activated protein kinase (AMPK) is a metabolic-stress-sensing protein kinase that regulates metabolism in response to energy demand and supply by…”
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Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase by Mitchelhill, K.I, Stapleton, D, Gao, G, House, C, Michell, B, Katsis, F, Witters, L.A, Kemp, B.E

“…The AMP-activated protein kinase is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It may also regulate…”
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Insulin activation of acetyl-CoA carboxylase accompanied by inhibition of the 5'-AMP-activated protein kinase by WITERS, L. A, KEMP, B. E

“…The activity of acetyl-CoA carboxylase (ACC), a rate-limiting enzyme of fatty acid biosynthesis and malonyl-CoA production, can be regulated by several…”
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Hepatic 5'-AMP-activated protein kinase: zonal distribution and relationship to acetyl-CoA carboxylase activity in varying nutritional states by Witters, L A, Gao, G, Kemp, B E, Quistorff, B

“…Acetyl-CoA carboxylase (ACC) activity in the liver varies markedly as a function of the nutritional state and is subject to complex regulation involving…”
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PPARα Is Necessary for the Lipopenic Action of Hyperleptinemia on White Adipose and Liver Tissue by Lee, Y., Yu, X., Gonzales, F., Mangelsdorf, D.J., Wang, May-Yun, Richardson, C., Witters, L.A., Unger, R.H.

“…Adenovirus-induced hyperleptinemia causes rapid disappearance of body fat in normal rats, presumably by up-regulating fatty acid oxidation within white…”
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Muscle phosphorylase kinase is not a substrate of AMP-activated protein kinase by Beyer, A, Kitzerow, A, Crute, B, Kemp, B E, Witters, L A, Heilmeyer, Jr, L M

“…AMP-activated protein kinase (AMPK) and cAMP-dependent protein kinase (cAMPK) have been reported to phosphorylate sites on phosphorylase kinase (PhK). Their…”
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Protein phosphorylation and dephosphorylation by Witters, L A

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Induction by glucose of genes coding for glycolytic enzymes in a pancreatic beta-cell (INS-1) by Roche, E, Assimacopolous-Jeannet, F, Witters, L.A, Perruchoud, B, Yaney, G, Corkey, B, Asfari, M, Prentki, M

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Insulin Stimulates the Dephosphorylation and Activation of Acetyl-CoA Carboxylase by Witters, Lee A., Watts, Thomas D., Daniels, Diana L., Evans, Joseph L.

“…The mechanism underlying the ability of insulin to acutely activate acetyl-CoA carboxylase [acetyl-CoA: carbon-dioxide ligase (ADP-forming), EC 6.4.1.2;…”
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Kinetic properties of carnitine palmitoyltransferase I in cultured neonatal rat cardiac myocytes by McMillin, J B, Wang, D, Witters, L A, Buja, L M

“…An understanding of the mechanism of malonyl-CoA interaction with carnitine palmitoyltransferase (CPT-I) in isolated mitochondria is complicated by membrane…”
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Yeast acetyl-CoA carboxylase: in vitro phosphorylation by mammalian and yeast protein kinases by Witters, L A, Watts, T D

“…Acetyl-CoA carboxylase (ACC) is regulated in mammalian tissues, in part, by multisite enzyme phosphorylation. Yeast ACC (Y-ACC) has been highly purified from…”
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Assignment of acetyl-CoA carboxylase-beta (ACACB) to human chromosome band 12q24.1 by in situ hybridization by Ullrich, C K, Widmer, J, Park, J P, Mohandas, T K, Witters, L A

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Brain acetyl-CoA carboxylase: isozymic identification and studies of its regulation during development and altered nutrition by Spencer, E B, Bianchi, A, Widmer, J, Witters, L A

“…Acetyl-CoA carboxylase, the rate-limiting enzyme of fatty acid synthesis, exists as an oligodendrocyte-associated enzyme in brain and plays an important role…”
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Glucagon regulation of protein phosphorylation. Identification of acetyl coenzyme A carboxylase as a substrate by Witters, L A, Kowaloff, E M, Avruch, J

“…A hormonally induced change in the covalent phosphorylation state of several enzymes is generally regarded as an important mechanism for hormonal modulation of…”
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Effects of glucagon and insulin on cytoplasmic protein phosphorylation in hepatocytes by Avruch, J, Witters, L A, Alexander, M C, Bush, M A

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Purification of a hepatic 123,000-dalton hormone-stimulated 32P-peptide and its identification as ATP-citrate lyase by Alexander, M C, Kowaloff, E M, Witters, L A, Dennihy, D T, Avruch, J

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Regulation of acetyl-CoA carboxylase by guanine nucleotides by Witters, L A, Friedman, S A, Tipper, J P, Bacon, G W

“…Acetyl-CoA carboxylase, a major rate-limiting enzyme for fatty acid synthesis, is subject to acute regulation by both allosteric modulation and covalent enzyme…”
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