Search Results - "Witter, Alexandra"

The Essential Role of Neutrophils during Infection with the Intracellular Bacterial Pathogen Listeria monocytogenes by Witter, Alexandra R, Okunnu, Busola M, Berg, Rance E

“…Neutrophils have historically been characterized as first responder cells vital to host survival because of their ability to contain and eliminate bacterial…”
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Profiling of the immune landscape in murine glioblastoma following blood brain/tumor barrier disruption with MR image-guided focused ultrasound by Sheybani, Natasha D., Witter, Alexandra R., Garrison, William J., Miller, G. Wilson, Price, Richard J., Bullock, Timothy N. J.

“…Purpose Glioblastoma (GB) poses formidable challenges to systemic immunotherapy approaches owing to the paucity of immune infiltration and presence of the…”
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Preclinical Efficacy of BCMA-Directed CAR T Cells Incorporating a Novel D Domain Antigen Recognition Domain by Buonato, Janine M, Edwards, Justin P, Zaritskaya, Liubov, Witter, Alexandra R, Gupta, Ankit, LaFleur, David W, Tice, David A, Richman, Laura K, Hilbert, David M

“…Chimeric antigen receptor (CAR) T-cell therapies directed against B-cell maturation antigen (BCMA) have shown compelling clinical activity and manageable…”
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Combination of thermally ablative focused ultrasound with gemcitabine controls breast cancer via adaptive immunity by Sheybani, Natasha D, Witter, Alexandra R, Thim, Eric A, Yagita, Hideo, Bullock, Timothy N J, Price, Richard J

“…BackgroundTriple-negative breast cancer (TNBC) remains recalcitrant to most targeted therapy approaches. However, recent clinical studies suggest that inducing…”
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Extracellular Superoxide Dismutase Enhances Recruitment of Immature Neutrophils to the Liver by Break, Timothy J, Witter, Alexandra R, Indramohan, Mohanalaxmi, Mummert, Mark E, Dory, Ladislav, Berg, Rance E

“…Listeria monocytogenes is a Gram-positive intracellular pathogen that causes spontaneous abortion in pregnant women, as well as septicemia, meningitis, and…”
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Chronic psychological stress suppresses contact hypersensitivity: Potential roles of dysregulated cell trafficking and decreased IFN-γ production by Hall, Jessica M.F, Witter, Alexandra R, Racine, Ronny R, Berg, Rance E, Podawiltz, Alan, Jones, Harlan, Mummert, Mark E

“…Abstract Increasing evidence shows that psychological stress can have dramatic impacts on the immune system, particularly the cutaneous immune response in…”
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Targeting immunosuppression for enhanced focused ultrasound efficacy in triple negative breast cancer by Petricca, Lydia E, Witter, Alexandra R, Sheybani, Natasha D, Thim, Eric A, Bullock, Timothy N, Price, Richard J

“…Immunologic rejection of triple-negative breast cancer (TNBC) is rare. Focused Ultrasound (FUS) promotes anti-tumor immunity by inducing tissue destruction and…”
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Focused ultrasound ablation as an immunomodulatory strategy for metastatic breast cancer therapy by Sheybani, Natasha Diba, Witter, Alexandra R., Stevens, Aaron D., Bullock, Timothy N., Price, Richard J.

“…Metastatic breast cancer (BrCa) is incurable, with a 5 year survival of only 22%. While immunotherapies are capable of generating durable responses in many…”
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MR image-guided focused ultrasound immune modulation for glioma therapy by Sheybani, Natasha Diba, Witter, Alexandra R., Bullock, Timothy N., Price, Richard J.

“…Glioblastoma (GB) is the most common and malignant brain tumor. Despite standard treatment with surgery, radiation and chemotherapy, its diffuse nature and…”
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Technical choices significantly alter the adaptive immune response against immunocompetent murine gliomas in a model-dependent manner by Noffsinger, Breanna, Witter, Alexandra, Sheybani, Natasha, Xiao, Aizhen, Manigat, Laryssa, Zhong, Qing, Taori, Suchet, Harris, Tajie, Bullock, Tim, Price, Richard, Purow, Benjamin

“…Purpose Due to the recent rise in immunotherapy research to treat glioblastoma (GBM), immunocompetent mouse models have become increasingly crucial. However,…”
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Extracellular superoxide dismutase promotes immature neutrophil egress from the bone marrow (INC6P.303) by Witter, Alexandra, Break, Timothy, Indramohan, Mohanalaxmi, Mummert, Mark, Berg, Rance

“…Extracellular superoxide dismutase (ecSOD) regulates extracellular concentrations of reactive oxygen species (ROS) to protect tissues during infection and…”
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The role of ecSOD in phagosomal containment of Listeria monocytogenes by neutrophils by Okunnu, Busola, Witter, Alexandra R, Swanta, Naomi K, Berg, Rance E

“…Extracellular superoxide dismutase (ecSOD) is an enzyme associated with the extracellular matrix that plays a protective role during reactive oxygen species…”
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The role of IL-23 in regulating the function of phagocytic cells during Listeria monocytogenes infection (MPF3P.822) by Indramohan, Mohanalaxmi, Break, Timothy, Witter, Alexandra, Berg, Rance

“…The IL-23/IL-17 axis contributes to autoimmune disorders, but is protective against certain pathogens, particularly extracellular bacteria. We have previously…”
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Abstract 587: ACLX-002, a novel CD123-targeted universal CAR-T cell therapy for relapsed or refractory acute myeloid leukemia that can be activated and silenced in vivo with soluble protein adapters in a dose dependent manner by Edwards, Justin P., Zaritskaya, Liubov, Swers, Jeff, Ng, Sinnie, Mu, Jenny, Witter, Alexandra, Cheung, Laurene, McCullough, Samantha, LaFleur, David, Hilbert, David, Tice, David

“…Genetically engineered T cells have demonstrated great promise in the treatment of hematologic malignancies including Acute Lymphocytic Leukemia, Non-Hodgkin’s…”
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Extracellular superoxide dismutase indirectly enhances the release of immature neutrophils from the murine bone marrow by Witter, Alexandra R

“…Extracellular superoxide dismutase (ecSOD) regulates extracellular concentrations of reactive oxygen species (ROS) to protect tissues during infection and…”
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