Search Results - "Wittenberger, Steven J."

A Laser Driven Flow Chemistry Platform for Scaling Photochemical Reactions with Visible Light by Harper, Kaid C, Moschetta, Eric G, Bordawekar, Shailendra V, Wittenberger, Steven J

“…Visible-light-promoted organic reactions can offer increased reactivity and selectivity via unique reaction pathways to address a multitude of practical…”
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The Enabling Technologies Consortium (ETC): Fostering Precompetitive Collaborations on New Enabling Technologies for Pharmaceutical Research and Development by Welch, Christopher J, Faul, Margaret M, Tummala, Srinivas, Papageorgiou, Charles D, Hicks, Frederick, Hawkins, Joel M, Thomson, Nicholas, Cote, Aaron, Bordawekar, Shailendra, Wittenberger, Steven J, Laffan, David, Purdie, Mark, Boulas, Pierre, Irdam, Erwin, Horspool, Keith, Yang, Bing-Shiou, Tom, Jean, Fernandez, Paul, Ferretti, Antonio, May, Scott, Seibert, Kevin, Wells, Kenneth, McKeown, Rahn

“…The creation of the Enabling Technologies Consortium (ETC) is described. The ETC fosters precompetitive collaborations aimed at the development and evaluation…”
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Development of a Catalytic Enantioselective Conjugate Addition of 1,3-Dicarbonyl Compounds to Nitroalkenes for the Synthesis of Endothelin-A Antagonist ABT-546. Scope, Mechanism, and Further Application to the Synthesis of the Antidepressant Rolipram by Barnes, David M, Ji, Jianguo, Fickes, Michael G, Fitzgerald, Michael A, King, Steven A, Morton, Howard E, Plagge, Frederick A, Preskill, Margo, Wagaw, Seble H, Wittenberger, Steven J, Zhang, Ji

“…The enantioselective synthesis of endothelin-A antagonist ABT-546 has been accomplished via the discovery and development of a highly selective catalytic…”
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Catalytic Enantioselective Conjugate Addition of 1,3-Dicarbonyl Compounds to Nitroalkenes by Ji, Jianguo, Barnes, David M, Zhang, Ji, King, Steven A, Wittenberger, Steven J, Morton, Howard E

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Addition of Organometallic Reagents to N-Glycosyl Nitrones. Enantioselective Syntheses of (+)-(R)- and (-)-(S)-Zileuton by Basha, Anwer, Henry, Rodger, McLaughlin, Maureen A, Ratajczyk, James D, Wittenberger, Steven J

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2,2,2-Trifluoroethyl Formate:  A Versatile and Selective Reagent for the Formylation of Alcohols, Amines, and N-Hydroxylamines by Hill, David R, Hsiao, Chi-Nung, Kurukulasuriya, Ravi, Wittenberger, Steven J

“…Treatment of a variety of alcohols, amines, and N-hydroxylamines with 2,2,2-trifluoroethyl formate gave the corresponding formylated adducts in high yields…”
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The Development of a Large-Scale Synthesis of Matrix Metalloproteinase Inhibitor, ABT-518 by Chang, Sou-Jen, Fernando, Dilinie, Fickes, Michael, Gupta, Ashok K, Hill, David R, McDermott, Todd, Parekh, Shyamal, Tian, Zhenping, Wittenberger, Steven J

“…A process for the preparation of matrix metalloproteinase inhibitor ABT-518 has been developed. Significant improvements have been made to the first generation…”
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Development of a Scalable Synthesis of Dipeptidyl Peptidase-4 Inhibitor ABT-279 by McDermott, Todd S, Bhagavatula, Lakshmi, Borchardt, Thomas B, Engstrom, Kenneth M, Gandarilla, Jorge, Kotecki, Brian J, Kruger, Albert W, Rozema, Michael J, Sheikh, Ahmad Y, Wagaw, Seble H, Wittenberger, Steven J

“…A convergent, scalable synthesis of dipeptidyl peptidase-4 inhibitor, ABT-279, has been developed and demonstrated on multikilogram scale. The…”
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A highly diastereoselective vinylogous Mannich condensation and 1,4-conjugate addition of ( Z)-propenyl cuprate in the synthesis of an influenza neuraminidase inhibitor by Barnes, David M., Bhagavatula, Lakshmi, DeMattei, John, Gupta, Ashok, Hill, David R., Manna, Sukumar, McLaughlin, Maureen A., Nichols, Paul, Premchandran, Ramiya, Rasmussen, Michael W., Tian, Zhenping, Wittenberger, Steven J.

“…A practical synthesis of neuraminidase influenza inhibitor, A-322278, has been developed. Asymmetry is introduced into the synthesis by an enzyme mediated…”
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Impurity rejection in the crystallization of ABT-510 as a method to establish starting material specifications by Tolle, John C, Becker, Calvin L, Califano, Jean C, Chang, Jane L, Gernhardt, Kevin, Napier, James J, Wittenberger, Steven J, Yuan, Judy

“…Understanding impurity rejection in a drug substance crystallization process is valuable for establishing purity specifications for the starting materials used…”
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Dialkyltin oxide mediated addition of trimethylsilyl azide to nitriles. A novel preparation of 5-substituted tetrazols by Wittenberger, Steven J, Donner, B. Gregory

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A Scaleable Synthesis of Fiduxosin by Haight, Anthony R, Bailey, Anne E, Baker, William S, Cain, Michael H, Copp, Richard R, DeMattei, John A, Ford, Kelley L, Henry, Rodger F, Hsu, Margaret C, Keyes, Robert F, King, Steven A, McLaughlin, Maureen A, Melcher, Laura M, Nadler, William R, Oliver, Patricia A, Parekh, Shyamal I, Patel, Hemant H, Seif, Louis S, Staeger, Mike A, Wayne, Gregory S, Wittenberger, Steven J, Zhang, Weijiang

“…Fiduxosin (1) has been under development at Abbott Laboratories for the treatment of benign prostatic hyperplasia. A convergent strategy required methodologies…”
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An Improved Synthesis of Pyran-3,5-dione:  Application to the Synthesis of ABT-598, a Potassium Channel Opener, via Hantzsch Reaction by Li, Wenke, Wayne, Gregory S, Lallaman, John E, Chang, Sou-Jen, Wittenberger, Steven J

“…Ketoester 1 is cyclized to give pyran-3,5-dione 2 in 78% yield using a parallel addition of ketoester 1 and base NaO t Bu in refluxing THF. Compared to the…”
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An Efficient Synthesis of the Cholinergic Channel Activator ABT-418 by Wittenberger, Steven J

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Synthesis of an Influenza Neuraminidase Inhibitor Intermediate via a Highly Diastereoselective Coupling Reaction by Barnes, David M, McLaughlin, Maureen A, Oie, Tetsuro, Rasmussen, Michael W, Stewart, Kent D, Wittenberger, Steven J

“…A highly diastereoselective coupling reaction between TBSOP (3) and trityl sulfenimine 4 was developed which provided influenza neuraminidase inhibitor…”
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An Efficient Scalable Process for the Synthesis of N-Boc-2-tert-butyldimethylsiloxypyrrole by Tian, Zhenping, Rasmussen, Michael, Wittenberger, Steven J

“…A safe, reliable and scalable process for the preparation of N-Boc-2-tert-butyldimethylsiloxy-pyrrole (TBSOP) is described. In a three-step, one-pot sequence…”
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Heuristics, Protocol, and Considerations for Flow Chemistry in Photoredox Catalysis by Moschetta, Eric G., Richter, Steven M., Wittenberger, Steven J.

“…Heuristics for employing photoredox catalysts in coiled‐tube LED reactors for flow chemistry are presented. These heuristics focus on common reaction…”
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A general synthesis of N-aryl- and N-alkyl-2-aminobenzoxazoles by Tian, Zhenping, Plata, Daniel J., Wittenberger, Steven J., Bhatia, Ashok V.

“…An efficient and practical synthetic procedure is described for the preparation of a variety of N-substituted aryl- and alkyl-2-aminobenzoxazoles. This new…”
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Dialkyltin oxide mediated addition of trimethylsilyl azide to nitriles. A novel preparation of 5-substituted tetrazoles by WITTENBERGER, S. J, DONNER, B. G

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The synthesis of ketolide antibiotic ABT-773 (cethromycin) by Plata, Daniel J., Leanna, M. Robert, Rasmussen, Michael, McLaughlin, Maureen A., Condon, Steven L., Kerdesky, Francis A.J., King, Steven A., Peterson, Matthew J., Stoner, Eric J., Wittenberger, Steven J.

“…A practical and efficient synthesis of ketolide antibiotic cethromycin (ABT-773) ( 1 ) is described. An effective protection strategy allows high yielding,…”
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