Search Results - "Wittenberg, Gayle"

Immune targets for therapeutic development in depression: towards precision medicine by Drevets, Wayne C., Wittenberg, Gayle M., Bullmore, Edward T., Manji, Husseini K.

“…Over the past two decades, compelling evidence has emerged indicating that immune mechanisms can contribute to the pathogenesis of major depressive disorder…”
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Replicable and Coupled Changes in Innate and Adaptive Immune Gene Expression in Two Case-Control Studies of Blood Microarrays in Major Depressive Disorder by Leday, Gwenaël G.R., Vértes, Petra E., Richardson, Sylvia, Greene, Jonathan R., Regan, Tim, Khan, Shahid, Henderson, Robbie, Freeman, Tom C., Pariante, Carmine M., Harrison, Neil A., Bullmore, Edward, Bullmore, Edward, Vertes, Petra, Cardinal, Rudolf, Richardson, Sylvia, Leday, Gwenael, Freeman, Tom, Regan, Tim, Hume, David, Wu, Zhaozong, Pariante, Carmine, Cattaneo, Annamaria, Zunszain, Patricia, Borsini, Alessandra, Stewart, Robert, Chandran, David, Carvalho, Livia, Bell, Joshua, Souza-Teodoro, Luis, Perry, Hugh, Harrison, Neil, Drevets, Wayne, Wittenberg, Gayle, Jones, Declan, Khan, Shahid, Stylianou, Annie, Henderson, Robbie, Perry, V. Hugh, Drevets, Wayne C., Wittenberg, Gayle M., Bullmore, Edward T.

“…Peripheral inflammation is often associated with major depressive disorder (MDD), and immunological biomarkers of depression remain a focus of investigation…”
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Effects of immunomodulatory drugs on depressive symptoms: A mega-analysis of randomized, placebo-controlled clinical trials in inflammatory disorders by Wittenberg, Gayle M., Stylianou, Annie, Zhang, Yun, Sun, Yu, Gupta, Ashutosh, Jagannatha, P. S., Wang, Dai, Hsu, Benjamin, Curran, Mark E., Khan, Shahid, Chen, Guang, Bullmore, Edward T., Drevets, Wayne C.

“…Activation of the innate immune system is commonly associated with depression. Immunomodulatory drugs may have efficacy for depressive symptoms that are…”
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Major Depressive Disorder Is Associated With Differential Expression of Innate Immune and Neutrophil-Related Gene Networks in Peripheral Blood: A Quantitative Review of Whole-Genome Transcriptional Data From Case-Control Studies by Wittenberg, Gayle M., Greene, Jon, Vértes, Petra E., Drevets, Wayne C., Bullmore, Edward T.

“…Whole-genome transcription has been measured in peripheral blood samples as a candidate biomarker of inflammation associated with major depressive disorder. We…”
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MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes by Lopez, Juan Pablo, Fiori, Laura M., Cruceanu, Cristiana, Lin, Rixing, Labonte, Benoit, Cates, Hannah M., Heller, Elizabeth A., Vialou, Vincent, Ku, Stacy M., Gerald, Christophe, Han, Ming-Hu, Foster, Jane, Frey, Benicio N., Soares, Claudio N., Müller, Daniel J., Farzan, Faranak, Leri, Francesco, MacQueen, Glenda M., Feilotter, Harriet, Tyryshkin, Kathrin, Evans, Kenneth R., Giacobbe, Peter, Blier, Pierre, Lam, Raymond W., Milev, Roumen, Parikh, Sagar V., Rotzinger, Susan, Strother, Steven C., Lewis, Cathryn M., Aitchison, Katherine J., Wittenberg, Gayle M., Mechawar, Naguib, Nestler, Eric J., Uher, Rudolf, Kennedy, Sidney H., Turecki, Gustavo

“…Antidepressants (ADs) are the most common treatment for major depressive disorder (MDD). However, only ∼30% of patients experience adequate response after a…”
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Ketamine and Imipramine Reverse Transcriptional Signatures of Susceptibility and Induce Resilience-Specific Gene Expression Profiles by Bagot, Rosemary C, Cates, Hannah M, Purushothaman, Immanuel, Vialou, Vincent, Heller, Elizabeth A, Yieh, Lynn, LaBonté, Benoit, Peña, Catherine J, Shen, Li, Wittenberg, Gayle M, Nestler, Eric J

“…Abstract Background Examining transcriptional regulation by antidepressants in key neural circuits implicated in depression and understanding the relation to…”
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The effects of interleukin-6 neutralizing antibodies on symptoms of depressed mood and anhedonia in patients with rheumatoid arthritis and multicentric Castleman’s disease by Sun, Yu, Wang, Dai, Salvadore, Giacomo, Hsu, Benjamin, Curran, Mark, Casper, Corey, Vermeulen, Jessica, Kent, Justine M., Singh, Jaskaran, Drevets, Wayne C., Wittenberg, Gayle M., Chen, Guang

“…•Diseases include rheumatoid arthritis (RA) and multicentric Castleman’s disease (MCD).•36-item short form health survey questionnaire is used for depressive…”
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Brain amyloid load, subjective memory complaints, and cognitive trajectories in older individuals at risk for dementia by Saadmaan, Gazi, Hall, Anette, Ngandu, Tiia, Kemppainen, Nina, Mangialasche, Francesca, Wittenberg, Gayle M., Matton, Anna, Rinne, Juha O., Kivipelto, Miia, Solomon, Alina

“…Background and Purpose This study evaluated associations of brain amyloid with 2‐year objective and subjective cognitive measures in a trial‐ready older…”
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Metabolomic biosignature differentiates melancholic depressive patients from healthy controls by Liu, Yashu, Yieh, Lynn, Yang, Tao, Drinkenburg, Wilhelmus, Peeters, Pieter, Steckler, Thomas, Narayan, Vaibhav A, Wittenberg, Gayle, Ye, Jieping

“…Major depressive disorder (MDD) is a heterogeneous disease at the level of clinical symptoms, and this heterogeneity is likely reflected at the level of…”
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Clinical Relevance of Sleep Duration: Results from a Cross-Sectional Analysis Using NHANES by Cepeda, M Soledad, Stang, Paul, Blacketer, Clair, Kent, Justine M, Wittenberg, Gayle M

“…To assess the clinical relevance of sleep duration, hours slept were compared by health status, presence of insomnia, and presence of depression, and the…”
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Malleability of Spike-Timing-Dependent Plasticity at the CA3-CA1 Synapse by Wittenberg, Gayle M, Wang, Samuel S.-H

“…The magnitude and direction of synaptic plasticity can be determined by the precise timing of presynaptic and postsynaptic action potentials on a millisecond…”
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Application of Real-World Data and the REWARD Framework to Detect Unknown Benefits of Memantine and Identify Potential Disease Targets for New NMDA Receptor Antagonists by Kern, David M., Cepeda, M. Soledad, Flores, Christopher M., Wittenberg, Gayle M.

“…Background Observational data may inform novel drug development programs by identifying previously unappreciated, clinical benefits of existing drugs. Several…”
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Spike timing dependent plasticity: a consequence of more fundamental learning rules by Shouval, Harel Z, Wang, Samuel S-H, Wittenberg, Gayle M

“…Spike timing dependent plasticity (STDP) is a phenomenon in which the precise timing of spikes affects the sign and magnitude of changes in synaptic strength…”
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Graded Bidirectional Synaptic Plasticity Is Composed of Switch-Like Unitary Events by O'Connor, Daniel H., Wittenberg, Gayle M., Samuel S.-H. Wang, Nicoll, Roger A.

“…Biological information storage events are often rapid transitions between discrete states. In neural systems, the initiation of bidirectional plasticity by…”
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Revealing Unknown Benefits of Existing Medications to Aid the Discovery of New Treatments for Post‐Traumatic Stress Disorder by Kern, David M., Teneralli, Rachel E., Flores, Christopher M., Wittenberg, Gayle M., Gilbert, James P., Cepeda, M. Soledad

“…Objective To systematically identify novel pharmacological strategies for preventing or treating post‐traumatic stress disorder (PTSD) by leveraging…”
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The Mechanisms of Differential Sensitivity to an Insulin-like Growth Factor-1 Receptor Inhibitor (BMS-536924) and Rationale for Combining with EGFR/HER2 Inhibitors by FEI HANG, GREET, Ann, LEE, Francis Y, GOTTARDIS, Marco M, CLARK, Edwin, HELMAN, Lee, ATTAR, Ricardo M, DONGRE, Ashok, CARBONIC, Joan M, HURLBURT, Warren, XIA HAN, HAFEZI, Rameh, WITTENBERG, Gayle M, REEVES, Karen, JIWEN CHEN, ROBINSON, Douglas, AIXIN LI

“…Overexpression and enhanced activity of insulin-like growth factor-I receptor (IGF-IR) in diverse tumor types make it an attractive target for cancer therapy…”
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Repeated exposure to systemic inflammation and risk of new depressive symptoms among older adults by Bell, J A, Kivimäki, M, Bullmore, E T, Steptoe, A, Carvalho, L A

“…Evidence on systemic inflammation as a risk factor for future depression is inconsistent, possibly due to a lack of regard for persistency of exposure. We…”
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Side effect profile similarities shared between antidepressants and immune-modulators reveal potential novel targets for treating major depressive disorders by Sun, Yu, Narayan, Vaibhav A, Wittenberg, Gayle M

“…Side effects, or the adverse effects of drugs, contain important clinical phenotypic information that may be useful in predicting novel or unknown targets of a…”
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Regulatory considerations for developing remote measurement technologies for Alzheimer’s disease research by Erdemli, Gül, Grammatikopoulou, Margarita, Wagner, Bertil, Vairavan, Srinivasan, Curcic, Jelena, Aarsland, Dag, Wittenberg, Gayle, Nikolopoulos, Spiros, Muurling, Marijn, Froehlich, Holger, de Boer, Casper, Shanbhag, Niraj M., Nies, Vera J. M., Coello, Neva, Gove, Dianne, Diaz, Ana, Foy, Suzanne, Dartee, Wim, Brem, Anna-Katharine

“…The Remote Assessment of Disease and Relapse – Alzheimer’s Disease (RADAR-AD) consortium evaluated remote measurement technologies (RMTs) for assessing…”
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Identifying amyloid pathology–related cerebrospinal fluid biomarkers for Alzheimer's disease in a multicohort study by Leung, Yuk Yee, Toledo, Jon B, Nefedov, Alexey, Polikar, Robi, Raghavan, Nandini, Xie, Sharon X, Farnum, Michael, Schultz, Tim, Baek, Young, Van Deerlin, Vivianna M, Hu, William T, Holtzman, David M, Fagan, Anne M, Perrin, Richard J, Grossman, Murray, Soares, Holly D, Kling, Mitchel A, Mailman, Matthew, Arnold, Steven E, Narayan, Vaibhav A, Lee, Virginia M-Y, Shaw, Leslie M, Baker, David, Wittenberg, Gayle M, Trojanowski, John Q, Wang, Li-San

“…Abstract Introduction The dynamic range of cerebrospinal fluid (CSF) amyloid β (Aβ1–42 ) measurement does not parallel to cognitive changes in Alzheimer's…”
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