Search Results - "Witten, Michael R."

Catalytic Asymmetric Synthesis of 8-Oxabicyclooctanes by Intermolecular [5+2] Pyrylium Cycloadditions by Witten, Michael R., Jacobsen, Eric N.

“…Highly enantioselective intermolecular [5+2] cycloadditions of pyrylium ion intermediates with electron‐rich alkenes are promoted by a dual catalyst system…”
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Dual Catalysis in Enantioselective Oxidopyrylium-Based [5 + 2] Cycloadditions by Burns, Noah Z, Witten, Michael R, Jacobsen, Eric N

“…A new method for effecting catalytic enantioselective intramolecular [5 + 2] cycloadditions based on oxidopyrylium intermediates is reported. The dual catalyst…”
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Rhodium(III)-Catalyzed Imidoyl C–H Activation for Annulations to Azolopyrimidines by Halskov, Kim Søholm, Witten, Michael R, Hoang, Gia L, Mercado, Brandon Q, Ellman, Jonathan A

“…Azolopyrimidines are efficiently prepared by direct imidoyl C–H bond activation. Annulations of N-azolo imines with sulfoxonium ylides and diazoketones under…”
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A Simple Primary Amine Catalyst for Enantioselective α‑Hydroxylations and α‑Fluorinations of Branched Aldehydes by Witten, Michael R., Jacobsen, Eric N.

“…A new primary amine catalyst for the asymmetric α-hydroxylation and α-fluorination of α-branched aldehydes is described. The products of the title…”
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Inhibition of ALK2 with bicyclic pyridyllactams by Witten, Michael R., Wu, Liangxing, Lai, Cheng-Tsung, Kapilashrami, Kanishk, Pusey, Michelle, Gallagher, Karen, Chen, Yaoyu, Yao, Wenqing

“…[Display omitted] Activin receptor-like kinase 2 (ALK2) has been implicated as a key target in multiple rare diseases. Herein, we describe the design of a…”
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Catalytic Asymmetric Synthesis of 8-Oxabicyclooctanes by Intermolecular [5+2] Pyrylium Cycloadditions by Witten, Michael R., Jacobsen, Eric N.

“…Highly enantioselective intermolecular [5+2] cycloadditions of pyrylium ion intermediates with electron‐rich alkenes are promoted by a dual catalyst system…”
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Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant Fibroblast Growth Factor Receptor (FGFR) 2/3 by Shvartsbart, Artem, Roach, Jeremy J., Witten, Michael R., Koblish, Holly, Harris, Jennifer J., Covington, Maryanne, Hess, Rodrigo, Lin, Luping, Frascella, Michelle, Truong, Lisa, Leffet, Lynn, Conlen, Patricia, Beshad, Elham, Klabe, Ron, Katiyar, Kamna, Kaldon, Laura, Young-Sciame, Ruth, He, Xin, Petusky, Susan, Chen, Kwang-Jong, Horsey, April, Lei, Hsiang-Ting, Epling, Leslie B., Deller, Marc C., Vechorkin, Oleg, Yao, Wenqing

“…Upregulation of the fibroblast growth factor receptor (FGFR) signaling pathway has been implicated in multiple cancer types, including cholangiocarcinoma and…”
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X‑ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors by Witten, Michael R, Wissler, Lisa, Snow, Melanie, Geschwindner, Stefan, Read, Jon A, Brandon, Nicholas J, Nairn, Angus C, Lombroso, Paul J, Käck, Helena, Ellman, Jonathan A

“…Excessive activity of striatal-enriched protein tyrosine phosphatase (STEP) in the brain has been detected in numerous neuropsychiatric disorders including…”
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Discovery of Novel Pyrazolopyrimidines as Potent, Selective, and Orally Bioavailable Inhibitors of ALK2 by Nguyen, Minh H., Atasoylu, Onur, Wu, Liangxing, Kapilashrami, Kanishk, Pusey, Michelle, Gallagher, Karen, Lai, Cheng-Tsung, Zhao, Peng, Barbosa, Joseph, Liu, Kai, He, Chunhong, Zhang, Colin, Styduhar, Evan D., Witten, Michael R., Chen, Yaoyu, Lin, Luping, Yang, Yan-ou, Covington, Maryanne, Diamond, Sharon, Yeleswaram, Swamy, Yao, Wenqing

“…Activin receptor-like kinase 2 (ALK2) is a transmembrane kinase receptor that mediates the signaling of the members of the TGF-β superfamily. The aberrant…”
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Discovery of Orally Bioavailable FGFR2/FGFR3 Dual Inhibitors via Structure-Guided Scaffold Repurposing Approach by Nguyen, Minh H., Ye, Hai-Fen, Xu, Yao, Truong, Lisa, Horsey, April, Zhao, Peng, Styduhar, Evan D., Frascella, Michelle, Leffet, Lynn, Federowicz, Kelly, Behshad, Elham, Wang, Anlai, Zhang, Ke, Witten, Michael R., Qi, Chao, Jalluri, Ravi, Lai, Cheng-Tsung, Atasoylu, Onur, Harris, Jennifer J., Hess, Rodrigo, Lin, Luping, Zhang, Guofeng, Covington, Maryanne, Diamond, Sharon, Yao, Wenqing, Vechorkin, Oleg

“…Fibroblast growth factor receptors (FGFRs) are transmembrane receptor tyrosine kinases that regulate multiple physiological processes. Aberrant activation of…”
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Solid phase synthesis of hydrogen bond surrogate derived alpha-helices: resolving the case of a difficult amide coupling by Patgiri, Anupam, Witten, Michael R, Arora, Paramjit S

“…Solid phase synthesis of HBS helices involving the Fukuyama-Mitsunobu reaction and triphosgene coupling is described…”
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New meta-terphenyl-derived primary amines in asymmetric catalysis by Witten, Michael R

“…In this dissertation, two distinct asymmetric reaction types are described: [5 + 2] pyrylium cycloadditions and aldehyde ?-functionalizations. Both reactions…”
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New meta-terphenyl-derived primary amines in asymmetric catalysis by Witten, Michael R

“…In this dissertation, two distinct asymmetric reaction types are described: [5 + 2] pyrylium cycloadditions and aldehyde ?-functionalizations. Both reactions…”
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