Search Results - "Witte, Pam"

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety by Burgin, Alex B, Gurney, Mark E, Magnusson, Olafur T, Singh, Jasbir, Witte, Pam, Staker, Bart L, Bjornsson, Jon M, Thorsteinsdottir, Margret, Hrafnsdottir, Sigrun, Hagen, Timothy, Kiselyov, Alex S, Stewart, Lance J

“…Finding safe inhibitors of phosphodiesterase 4, the enzyme that breaks down cAMP, has been a longstanding goal in pharmaceutical development. Burgin et al …”
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Liposomes for photodynamic therapy by Derycke, Annelies S.L., de Witte, Peter A.M.

“…Photodynamic therapy (PDT) is an evolving modality for the treatment of superficial tumors. The technique utilizes photosensitizing agents that are able to…”
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Hypericin in cancer treatment: more light on the way by Agostinis, Patrizia, Vantieghem, Annelies, Merlevede, Wilfried, de Witte, Peter A.M.

“…Photodynamic therapy (PDT) has been described as a promising new modality for the treatment of cancer. PDT involves the combination of a photosensitizing agent…”
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Structure and function of a cyanophage-encoded peptide deformylase by Frank, Jeremy A, Lorimer, Don, Youle, Merry, Witte, Pam, Craig, Tim, Abendroth, Jan, Rohwer, Forest, Edwards, Robert A, Segall, Anca M, Burgin, Alex B

“…Bacteriophages encode auxiliary metabolic genes that support more efficient phage replication. For example, cyanophages carry several genes to maintain host…”
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Transferrin-Conjugated Liposome Targeting of Photosensitizer AlPcS4 to Rat Bladder Carcinoma Cells by Derycke, Annelies S. L., Kamuhabwa, Appolinary, Gijsens, Antoon, Roskams, Tania, De Vos, Dirk, Kasran, Ahmad, Huwyler, Jörg, Missiaen, Ludwig, de Witte, Peter A. M.

“…Background: The efficacy and safety of photodynamic therapy for superficial bladder cancer depend on tumor-selective accumulation of the photosensitizer…”
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Crystal structures of Mycobacterial MeaB and MMAA-like GTPases by Edwards, Thomas E., Baugh, Loren, Bullen, Jameson, Baydo, Ruth O., Witte, Pam, Thompkins, Kaitlin, Phan, Isabelle Q. H., Abendroth, Jan, Clifton, Matthew C., Sankaran, Banumathi, Van Voorhis, Wesley C., Myler, Peter J., Staker, Bart L., Grundner, Christoph, Lorimer, Donald D.

“…The methylmalonyl Co-A mutase-associated GTPase MeaB from Methylobacterium extorquens is involved in glyoxylate regulation and required for growth. In humans,…”
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Hypericin‐based fluorescence diagnosis of bladder carcinoma by D'Hallewin, M.‐A., Kamuhabwa, A.R., Roskams, T., De Witte, P.A.M., Baert, L.

“…Objective To determine the use of hypericin instillation for the fluorescent detection of papillary bladder cancer and carcinoma in situ. Patients and methods…”
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Photodynamic therapy with hypericin induces vascular damage and apoptosis in the RIF‐1 mouse tumor model by Chen, Bin, Roskams, Tania, Xu, Yan, Agostinis, Patrizia, de Witte, Peter A.M.

“…Hypericin, a polycyclic quinone obtained from plants of the genus Hypericum, has been proven to be a potent photosensitizer. The mechanism of tumor eradication…”
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The impact of aggregation on the biodistribution of hypericin by VAN DE PUTTE, Marie, ROSKAMS, Tania, BORMANS, Guy, VERBRUGGEN, Alfons, DE WITTE, Peter A. M

“…Hypericin is a potent agent in the photodynamic therapy of cancers and accumulates to a large extent in tumor tissue. To better understand the impact of…”
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Elucidation of the tumoritropic principle of hypericin by VAN DE PUTTE, M, ROSKAMS, T, VANDENHEEDE, J. R, AGOSTINIS, P, DE WITTE, P. A. M

“…Hypericin is a potent agent in the photodynamic therapy of cancers. To better understand its tumoritropic behaviour, we evaluated the major determinants of the…”
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Stability of different formulations and ion pairs of hypericin by Huygens, Ann, Kamuhabwa, Appolinary R., de Witte, Peter A.M.

“…Hypericin, solubilized in an instillation fluid consisting of an aqueous buffer supplemented with 1% plasma proteins, is currently used as a clinical…”
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Antivascular Tumor Eradication by Hypericin-mediated Photodynamic Therapy by Chen, Bin, Roskams, Tania, de Witte, Peter A. M.

“…Photodynamic therapy (PDT) with hypericin has been shown to inhibit tumor growth in different tumor models, and tumor vascular damage was suggested to be…”
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Transferrin-mediated targeting of hypericin embedded in sterically stabilized PEG-liposomes by Derycke, Annelies S L, De Witte, Peter A M

“…Over the last few decades, photodynamic therapy evolved to a promising new treating modality for cancer. The photosensitizers used, induce light sensitivity to…”
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Permeation of hypericin in spheroids composed of different grade transitional cell carcinoma cell lines and normal human urothelial cells by Huygens, Ann, Kamuhabwa, Appolinary R, Roskams, Tania, VAN Cleynenbreugel, Ben, VAN Poppel, Hendrik, de Witte, Peter A M

“…We investigated the importance of E-cadherin expression on the selective accumulation of hypericin in superficial bladder cancer after intravesical…”
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Whole bladder wall photodynamic therapy of transitional cell carcinoma rat bladder tumors using intravesically administered hypericin by Kamuhabwa, Appolinary A.R., Roskams, Tania, D'Hallewin, Marie‐Ange, Baert, Luc, Van Poppel, Hein, de Witte, Peter A.M.

“…Whole‐bladder wall photodynamic therapy (PDT) is a promising treatment for carcinoma in situ (CIS) and diffuse premalignant changes of the bladder. After the…”
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Enhancing the photodynamic effect of hypericin in human bladder transitional cell carcinoma spheroids by the use of the oxygen carrier, perfluorodecalin by KAMUHABWA, Appolinary R, HUYGENS, Ann, ROSKAMS, Tania, DE WITTE, Peter A. M

“…In the present study, we evaluated the possibility of enhancing the photodynamic effect of hypericin in transitional cell carcinoma (TCC) spheroids by the use…”
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Synthesis, in vitro cellular uptake and photo-induced antiproliferative effects of lipophilic hypericin acid derivatives by Crnolatac, Ivo, Huygens, Ann, van Aerschot, Arthur, Busson, Roger, Rozenski, Jef, de Witte, Peter A.M.

“…Hypericin, a naturally occurring hydroxylated phenanthroperylene dione, is used as a powerful photosensitizer for photodynamic therapy as well as a diagnostic…”
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Biodistribution of hypericin in orthotopic transitional cell carcinoma bladder tumors: Implication for whole bladder wall photodynamic therapy by Kamuhabwa, Appolinary A.R., Cosserat‐Gerardin, Isabelle, Didelon, Jacques, Notter, Dominique, Guillemin, François, Roskams, Tania, D'Hallewin, Marie‐Ange, Baert, Luc, de Witte, Peter A.M.

“…In a recent clinical study, we reported a selective uptake of hypericin in superficial bladder tumors. The results suggested that hypericin, a potent…”
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Enhancing the photodynamic effect of hypericin in tumour spheroids by fractionated light delivery in combination with hyperoxygenation by Huygens, Ann, Kamuhabwa, Appolinary R, Van Laethem, An, Roskams, Tania, Van Cleynenbreugel, Ben, Van Poppel, Hendrik, Agostinis, Patrizia, De Witte, Peter A M

“…The aim of this study was to explore the hypothesis of oxygen depletion during light irradiation as a possible explanation for the incomplete response seen…”
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Accumulation and Photocytotoxicity of Hypericin and Analogs in Two- and Three-Dimensional Cultures of Transitional Cell Carcinoma Cells by Huygens, Ann, Huyghe, Dieter, Bormans, Guy, Verbruggen, Alfons, Kamuhabwa, Appolinary R., Roskams, Tania, de Witte, Peter A. M.

“…The aim of this study was to investigate the in vitro cellular accumulation, distribution and photocytotoxic effect of hypericin in two-dimensional (2-D) and…”
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