Search Results - "Witte, Owen"

An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy by Tavaré, Richard, Escuin-Ordinas, Helena, Mok, Stephen, McCracken, Melissa N, Zettlitz, Kirstin A, Salazar, Felix B, Witte, Owen N, Ribas, Antoni, Wu, Anna M

“…The rapidly advancing field of cancer immunotherapy is currently limited by the scarcity of noninvasive and quantitative technologies capable of monitoring the…”
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FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate by Park, Jung Wook, Lee, John K, Witte, Owen N, Huang, Jiaoti

“…The median survival of patients with small cell neuroendocrine carcinoma is significantly shorter than that of patients with classic acinar-type…”
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Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage by Park, Jung Wook, Lee, John K, Sheu, Katherine M, Wang, Liang, Balanis, Nikolas G, Nguyen, Kim, Smith, Bryan A, Cheng, Chen, Tsai, Brandon L, Cheng, Donghui, Huang, Jiaoti, Kurdistani, Siavash K, Graeber, Thomas G, Witte, Owen N

“…The use of potent therapies inhibiting critical oncogenic pathways active in epithelial cancers has led to multiple resistance mechanisms, including the…”
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Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study by Aggarwal, Rahul, Huang, Jiaoti, Alumkal, Joshi J, Zhang, Li, Feng, Felix Y, Thomas, George V, Weinstein, Alana S, Friedl, Verena, Zhang, Can, Witte, Owen N, Lloyd, Paul, Gleave, Martin, Evans, Christopher P, Youngren, Jack, Beer, Tomasz M, Rettig, Matthew, Wong, Christopher K, True, Lawrence, Foye, Adam, Playdle, Denise, Ryan, Charles J, Lara, Primo, Chi, Kim N, Uzunangelov, Vlado, Sokolov, Artem, Newton, Yulia, Beltran, Himisha, Demichelis, Francesca, Rubin, Mark A, Stuart, Joshua M, Small, Eric J

“…Purpose The prevalence and features of treatment-emergent small-cell neuroendocrine prostate cancer (t-SCNC) are not well characterized in the era of modern…”
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Identification of a Cell of Origin for Human Prostate Cancer by Goldstein, Andrew S., Huang, Jiaoti, Guo, Changyong, Garraway, Isla P., Witte, Owen N.

“…Luminal cells are believed to be the cells of origin for human prostate cancer, because the disease is characterized by luminal cell expansion and the absence…”
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Bmi-1 Is a Crucial Regulator of Prostate Stem Cell Self-Renewal and Malignant Transformation by Lukacs, Rita U., Memarzadeh, Sanaz, Wu, Hong, Witte, Owen N.

“…The Polycomb group transcriptional repressor Bmi-1 is often upregulated in prostate cancer, but its functional roles in prostate stem cell maintenance and…”
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A basal stem cell signature identifies aggressive prostate cancer phenotypes by Smith, Bryan A., Sokolov, Artem, Uzunangelov, Vladislav, Baertsch, Robert, Newton, Yulia, Graim, Kiley, Mathis, Colleen, Cheng, Donghui, Stuart, Joshua M., Witte, Owen N.

“…Evidence from numerous cancers suggests that increased aggressiveness is accompanied by up-regulation of signaling pathways and acquisition of properties…”
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Activation of GPR4 by acidosis increases endothelial cell adhesion through the cAMP/Epac pathway by Chen, Aishe, Dong, Lixue, Leffler, Nancy R, Asch, Adam S, Witte, Owen N, Yang, Li V

“…Endothelium-leukocyte interaction is critical for inflammatory responses. Whereas the tissue microenvironments are often acidic at inflammatory sites, the…”
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RNA Dysregulation: An Expanding Source of Cancer Immunotherapy Targets by Pan, Yang, Kadash-Edmondson, Kathryn E., Wang, Robert, Phillips, John, Liu, Song, Ribas, Antoni, Aplenc, Richard, Witte, Owen N., Xing, Yi

“…Cancer transcriptomes frequently exhibit RNA dysregulation. As the resulting aberrant transcripts may be translated into cancer-specific proteins, there is…”
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N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells by Lee, John K., Phillips, John W., Smith, Bryan A., Park, Jung Wook, Stoyanova, Tanya, McCaffrey, Erin F., Baertsch, Robert, Sokolov, Artem, Meyerowitz, Justin G., Mathis, Colleen, Cheng, Donghui, Stuart, Joshua M., Shokat, Kevan M., Gustafson, W. Clay, Huang, Jiaoti, Witte, Owen N.

“…MYCN amplification and overexpression are common in neuroendocrine prostate cancer (NEPC). However, the impact of aberrant N-Myc expression in prostate…”
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Clinical Targeting of Mutated and Wild-Type Protein Tyrosine Kinases in Cancer by Drake, Justin M., Lee, John K., Witte, Owen N.

“…Clinical therapies for cancer have evolved from toxic, nontargeted agents to manageable, highly targeted therapies. Protein tyrosine kinases are a family of…”
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Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer by Lee, John K., Bangayan, Nathanael J., Chai, Timothy, Smith, Bryan A., Pariva, Tiffany E., Yun, Sangwon, Vashisht, Ajay, Zhang, Qingfu, Park, Jung Wook, Corey, Eva, Huang, Jiaoti, Graeber, Thomas G., Wohlschlegel, James, Witte, Owen N.

“…Prostate cancer is a heterogeneous disease composed of divergent molecular and histologic subtypes, including prostate adenocarcinoma (PrAd) and neuroendocrine…”
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Pan-cancer Convergence to a Small-Cell Neuroendocrine Phenotype that Shares Susceptibilities with Hematological Malignancies by Balanis, Nikolas G., Sheu, Katherine M., Esedebe, Favour N., Patel, Saahil J., Smith, Bryan A., Park, Jung Wook, Alhani, Salwan, Gomperts, Brigitte N., Huang, Jiaoti, Witte, Owen N., Graeber, Thomas G.

“…Small-cell neuroendocrine cancers (SCNCs) are an aggressive cancer subtype. Transdifferentiation toward an SCN phenotype has been reported as a resistance…”
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Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay by Park, Jung Wook, Lee, John K., Phillips, John W., Huang, Patrick, Cheng, Donghui, Huang, Jiaoti, Witte, Owen N.

“…The cell of origin for prostate cancer remains a subject of debate. Genetically engineered mouse models have demonstrated that both basal and luminal cells can…”
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Engineered antibody fragments for immuno-PET imaging of endogenous CD8⁺ T cells in vivo by Tavaré, Richard, McCracken, Melissa N., Zettlitz, Kirstin A., Knowles, Scott M., Salazar, Felix B., Olafsen, Tove, Witte, Owen N., Wu, Anna M.

“…The noninvasive detection and quantification of CD8 ⁺ T cells in vivo are important for both the detection and staging of CD8 ⁺ lymphomas and for the…”
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Basal epithelial stem cells are efficient targets for prostate cancer initiation by Lawson, Devon A, Zong, Yang, Memarzadeh, Sanaz, Xin, Li, Huang, Jiaoti, Witte, Owen N

“…Prevailing theories suggest that luminal cells are the origin of prostate cancer because it is histologically defined by basal cell loss and malignant luminal…”
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Invasive Prostate Carcinoma Driven by c-Src and Androgen Receptor Synergy by HOUJIAN CAI, BABIC, Ivan, XIAO WEI, JIAOTI HUANG, WITTE, Owen N

“…Cellular Src (c-Src) integrates a large number of signal transduction pathways regulating cell division, migration, and other aspects of cell physiology…”
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Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer by Quigley, David A., Dang, Ha X., Zhao, Shuang G., Lloyd, Paul, Aggarwal, Rahul, Alumkal, Joshi J., Foye, Adam, Kothari, Vishal, Perry, Marc D., Bailey, Adina M., Playdle, Denise, Barnard, Travis J., Zhang, Li, Zhang, Jin, Youngren, Jack F., Cieslik, Marcin P., Parolia, Abhijit, Beer, Tomasz M., Thomas, George, Chi, Kim N., Gleave, Martin, Lack, Nathan A., Zoubeidi, Amina, Reiter, Robert E., Rettig, Matthew B., Witte, Owen, Ryan, Charles J., Fong, Lawrence, Kim, Won, Friedlander, Terence, Chou, Jonathan, Li, Haolong, Das, Rajdeep, Li, Hui, Moussavi-Baygi, Ruhollah, Goodarzi, Hani, Gilbert, Luke A., Lara, Primo N., Evans, Christopher P., Goldstein, Theodore C., Stuart, Joshua M., Tomlins, Scott A., Spratt, Daniel E., Cheetham, R. Keira, Cheng, Donavan T., Farh, Kyle, Gehring, Julian S., Hakenberg, Jörg, Liao, Arnold, Febbo, Philip G., Shon, John, Sickler, Brad, Batzoglou, Serafim, Knudsen, Karen E., He, Housheng H., Huang, Jiaoti, Wyatt, Alexander W., Dehm, Scott M., Ashworth, Alan, Chinnaiyan, Arul M., Maher, Christopher A., Small, Eric J., Feng, Felix Y.

“…While mutations affecting protein-coding regions have been examined across many cancers, structural variants at the genome-wide level are still poorly defined…”
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The DNA methylation landscape of advanced prostate cancer by Zhao, Shuang G., Chen, William S., Li, Haolong, Foye, Adam, Zhang, Meng, Sjöström, Martin, Aggarwal, Rahul, Playdle, Denise, Liao, Arnold, Alumkal, Joshi J., Das, Rajdeep, Chou, Jonathan, Hua, Junjie T., Barnard, Travis J., Bailey, Adina M., Chow, Eric D., Perry, Marc D., Dang, Ha X., Yang, Rendong, Moussavi-Baygi, Ruhollah, Zhang, Li, Alshalalfa, Mohammed, Laura Chang, S., Houlahan, Kathleen E., Shiah, Yu-Jia, Beer, Tomasz M., Thomas, George, Chi, Kim N., Gleave, Martin, Zoubeidi, Amina, Reiter, Robert E., Rettig, Matthew B., Witte, Owen, Yvonne Kim, M., Fong, Lawrence, Spratt, Daniel E., Morgan, Todd M., Bose, Rohit, Huang, Franklin W., Li, Hui, Chesner, Lisa, Shenoy, Tanushree, Goodarzi, Hani, Asangani, Irfan A., Sandhu, Shahneen, Lang, Joshua M., Mahajan, Nupam P., Lara, Primo N., Evans, Christopher P., Febbo, Phillip, Batzoglou, Serafim, Knudsen, Karen E., He, Housheng H., Huang, Jiaoti, Zwart, Wilbert, Costello, Joseph F., Luo, Jianhua, Tomlins, Scott A., Wyatt, Alexander W., Dehm, Scott M., Ashworth, Alan, Gilbert, Luke A., Boutros, Paul C., Farh, Kyle, Chinnaiyan, Arul M., Maher, Christopher A., Small, Eric J., Quigley, David A., Feng, Felix Y.

“…Although DNA methylation is a key regulator of gene expression, the comprehensive methylation landscape of metastatic cancer has never been defined. Through…”
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Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells by Jiao, Jing, Hindoyan, Antreas, Wang, Shunyou, Tran, Linh M, Goldstein, Andrew S, Lawson, Devon, Chen, Donghui, Li, Yunfeng, Guo, Changyong, Zhang, Baohui, Fazli, Ladan, Gleave, Martin, Witte, Owen N, Garraway, Isla P, Wu, Hong

“…New therapies for late stage and castration resistant prostate cancer (CRPC) depend on defining unique properties and pathways of cell sub-populations capable…”
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