Search Results - "Witte, Marlys"

Molecular mechanisms of cancer metastasis via the lymphatic versus the blood vessels by Leong, Stanley P., Naxerova, Kamila, Keller, Laura, Pantel, Klaus, Witte, Marlys

“…Cancer metastasis is the process by which primary cancer cells invade through the lymphatic or blood vessels to distant sites. The molecular mechanisms by…”
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Cancer metastasis through the lymphatic versus blood vessels by Leong, Stanley P., Witte, Marlys H.

“…Whether cancer cells metastasize from the primary site to the distant sites via the lymphatic vessels or the blood vessels directly into the circulation is…”
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Mechanisms of Ascites Development by Hearst Witte, Marlys

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Connexin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothorax by Kanady, John D., Dellinger, Michael T., Munger, Stephanie J., Witte, Marlys H., Simon, Alexander M.

“…Intraluminal valves are required for the proper function of lymphatic collecting vessels and large lymphatic trunks like the thoracic duct. Despite recent…”
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Primary lymphoedema by Brouillard, Pascal, Witte, Marlys H., Erickson, Robert P., Damstra, Robert J., Becker, Corinne, Quéré, Isabelle, Vikkula, Miikka

“…Lymphoedema is the swelling of one or several parts of the body owing to lymph accumulation in the extracellular space. It is often chronic, worsens if…”
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Lymphangiogenesis, lymphatic systemomics, and cancer: context, advances and unanswered questions by Dellinger, Michael T., Witte, Marlys H.

“…Ever since it was discovered that endothelial cells line lymphatic vessels, investigators have been working on unraveling the mechanisms that control the…”
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Combining Foxc2 and Connexin37 deletions in mice leads to severe defects in lymphatic vascular growth and remodeling by Kanady, John D., Munger, Stephanie J., Witte, Marlys H., Simon, Alexander M.

“…Connexins (Cxs), proteins that are vital for intercellular communication in vertebrates, have recently been shown to play a critical role in lymphatic…”
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Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier by Ramirez, Servio H, Brito, Maria A, Bernas, Michael J, Cardoso, Filipa L, Daley, Sarah K, Weinand, Martin E, Campos, Alexandre R, Ferreira, António J Gonçalves, Hoying, James B, Witte, Marlys H, Brites, Dora, Persidsky, Yuri

“…We describe a method for generating primary cultures of human brain microvascular endothelial cells (HBMVECs). HBMVECs are derived from microvessels isolated…”
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Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice by Dellinger, Michael, Hunter, Robert, Bernas, Michael, Gale, Nicholas, Yancopoulos, George, Erickson, Robert, Witte, Marlys

“…Molecular mechanisms regulating the remodeling of the lymphatic vasculature from an immature plexus of vessels to a hierarchal network of initial and…”
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Segregated Foxc2, NFATc1 and Connexin expression at normal developing venous valves, and Connexin-specific differences in the valve phenotypes of Cx37, Cx43, and Cx47 knockout mice by Munger, Stephanie J., Geng, Xin, Srinivasan, R. Sathish, Witte, Marlys H., Paul, David L., Simon, Alexander M.

“…Venous valves (VVs) are critical for unidirectional blood flow from superficial and deep veins towards the heart. Congenital valve aplasia or agenesis may, in…”
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Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity by Oliver, Guillermo, Harvey, Natasha L, Srinivasan, R Sathish, Dillard, Miriam E, Johnson, Nicole C, Witte, Marlys H, Boyd, Kelli, Sleeman, Mark W

“…Multiple organs cooperate to regulate appetite, metabolism, and glucose and fatty acid homeostasis. Here, we identified and characterized lymphatic vasculature…”
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Role of Lymphatic Deficiency in the Pathogenesis and Progression of Inflammatory Bowel Disease to Colorectal Cancer in an Experimental Mouse Model by Daley, Sarah K, Witte, Marlys H, Washington, Jalicia, Bernas, Michael, Kiela, Pawel, Thorn, Jennifer, Tanoue, Nathan, Alexander, J Steven

“…This paper explores the role of the lymphatic system in the progression of IBD to colorectal carcinoma using the Angiopoietin-2 lymphatic-deficient mouse…”
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Cancer and lymphatic marker FOXC2 drives wound healing and fibrotic tissue formation by Granoski, Maia B, Fischer, Katharina S, Hahn, William W, Sivaraj, Dharshan, Kussie, Hudson C, Quintero, Filiberto, Alsharif, Abdelrahman M, McKenna, Eamonn, Yasmeh, Jonathan P, Hostler, Andrew C, Mora Pinos, Maria Gracia, Erickson, Robert P, Witte, Marlys H, Chen, Kellen, Gurtner, Geoffrey C

“…The FOXC2 transcription factor has been tied to a wide range of disease states, serving as a promising prognostic biomarker associated with aggressive…”
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GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126 by Mahamud, Md Riaj, Geng, Xin, Ho, Yen-Chun, Cha, Boksik, Kim, Yuenhee, Ma, Jing, Chen, Lijuan, Myers, Greggory, Camper, Sally, Mustacich, Debbie, Witte, Marlys, Choi, Dongwon, Hong, Young-Kwon, Chen, Hong, Varshney, Gaurav, Engel, James Douglas, Wang, Shusheng, Kim, Tae-Hoon, Lim, Kim-Chew, Srinivasan, R Sathish

“…Mutations in the transcription factor GATA2 cause lymphedema. GATA2 is necessary for the development of lymphatic valves and lymphovenous valves, and for the…”
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Higher Incidence of Protein-Losing Enteropathy in Patients with Single Systemic Right Ventricle by Bernardi, Alyssa M., Moses, Sylvestor, Barber, Brent J., Witte, Marlys H., Seckeler, Michael D.

“…Patients with single ventricle congenital heart disease are at risk of unpredictable protein-losing enteropathy (PLE) after surgical palliation. Based on prior…”
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Cancer microenvironment and genomics: evolution in process by Leong, Stanley P., Witz, Isaac P., Sagi-Assif, Orit, Izraely, Sivan, Sleeman, Jonathan, Piening, Brian, Fox, Bernard A., Bifulco, Carlo B., Martini, Rachel, Newman, Lisa, Davis, Melissa, Sanders, Lauren M., Haussler, David, Vaske, Olena M., Witte, Marlys

“…Cancer heterogeneity is a result of genetic mutations within the cancer cells. Their proliferation is not only driven by autocrine functions but also under the…”
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Research Priorities in Lymphatic Interventions: Recommendations from a Multidisciplinary Research Consensus Panel by Itkin, Maxim, Rockson, Stanley G., Witte, Marlys H, Burkhoff, Daniel, Phillips, Anthony, Windsor, John A., Kassab, Ghassan S., Hur, Saebeom, Nadolski, Gregory, Pabon-Ramos, Waleska M., Rabinowitz, Debbie, White, Sarah B.

“…Recognizing the increasing importance of lymphatic interventions, the Society of Interventional Radiology Foundation brought together a multidisciplinary group…”
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Sex‐limited penetrance of lymphedema to females with CELSR1 haploinsufficiency: A second family by Erickson, Robert P., Lai, Li‐Wen, Mustacich, Debbie J., Bernas, Michael J., Kuo, Phillip H., Witte, Marlys H.

“…A second multigeneration family with hereditary lymphedema (LE) secondary to a variant in the planar polarity gene, CELSR1, is described. Dominant inheritance…”
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Angiopoietin-2 Is Required for Postnatal Angiogenesis and Lymphatic Patterning, and Only the Latter Role Is Rescued by Angiopoietin-1 by Gale, Nicholas W., Thurston, Gavin, Hackett, Sean F., Renard, Roumiana, Wang, Quan, McClain, Joyce, Martin, Cliff, Witte, Charles, Witte, Marlys H., Jackson, David, Suri, Chitra, Campochiaro, Peter A., Wiegand, Stanley J., Yancopoulos, George D.

“…VEGF and Angiopoietin-1 requisitely collaborate during blood vessel development. While Angiopoietin-1 obligately activates its Tie2 receptor, Angiopoietin-2…”
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Resolution of Protein-Losing Enteropathy after Congenital Heart Disease Repair by Selective Lymphatic Embolization by Kylat, Ranjit I, Witte, Marlys H, Barber, Brent J, Dori, Yoav, Ghishan, Fayez K

“…With improving survival of children with complex congenital heart disease (CCHD), postoperative complications, like protein-losing enteropathy (PLE) are…”
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