Search Results - "Witta, S. E."

ErbB-3 expression is associated with E-cadherin and their coexpression restores response to gefitinib in non-small-cell lung cancer (NSCLC) by Witta, S. E., Dziadziuszko, R., Yoshida, K., Hedman, K., Varella-Garcia, M., Bunn, P. A., Hirsch, F. R.

“…Background: Epidermal growth factor receptor (EGFR) inhibitors are effective in a subset of patients with non-small-cell lung cancer (NSCLC). We previously…”
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XIPOU 2, a noggin-inducible gene, has direct neuralizing activity by Witta, S E, Agarwal, V R, Sato, S M

“…XIPOU 2, a member of the class III POU domain family, is expressed initially in Spemann's organizer, and later, in discrete regions of the developing nervous…”
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Improvement of Neurological Deficits in 6-hydroxydopamine-Lesioned Rats after Transplantation with Allogeneic Simian Virus 40 Large Tumor Antigen Gene-Induced Immortalized Dopamine Cells by Clarkson, Edward D., La Rosa, Francisco G., Edwards-Prasad, Judith, Weiland, David A., Witta, Samir E., Freed, Curt R., Prasad, Kedar N.

“…The replacement of dopamine (DA) by DA neuron transplants in the treatment of advanced Parkinson disease (PD) is a rational approach. Because of limitations…”
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Somatic cell cloned transgenic bovine neurons for transplantation in parkinsonian rats by Zawada, W. Michael, Cibelli, Jose B, Choi, Paul K, Clarkson, Edward D, Golueke, Paul J, Witta, Samir E, Bell, K. Pat, Kane, Jeff, de Leon, F. Abel Ponce, Jerry, D. Joseph, Robl, James M, Freed, Curt R, Stice, Steven L

“…Parkinson's disease symptoms can be improved by transplanting fetal dopamine cells into the putamen of parkinsonian patients. Because the supply of human donor…”
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XIPOU 2 is a potential regulator of Spemann's Organizer by Witta, S E, Sato, S M

“…XIPOU 2, a member of the class III POU-domain family, is expressed initially at mid-blastula transition (MBT) and during gastrulation in the entire marginal…”
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Randomized, double-blind, placebo-controlled phase II study of erlotinib with and without entinostat, a class 1 isoform selective histone deacetylase inhibitor (HDAC), in patients with advanced non-small cell lung cancer (NSCLC; ENCORE-401) by Jotte, R., Witta, S. E., Neubauer, M. A., Spira, A. I., Konduri, K.

“…Abstract only…”
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Results from a phase I safety lead-in study investigating the combination of erlotinib and the histone deacetylase inhibitor entinostat in patients with advanced NSCLC by Konduri, K., Spira, A. I., Jotte, R. M., Boyd, T., Gaffar, Y. A., Reynolds, C., Witta, S. E.

“…Abstract only e14545 Background: Preclinical studies showed the synergistic effect of entinostat with epidermal growth factor tyrosine kinase inhibitors…”
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Synergistic effect of SNDX-275 with lapatinib or erlotinib in breast, lung, or head and neck cancer cell lines expressing HER- 2 by Witta, S. E., Franekova, V., Yoshida, K., Igolnikov, I., Frederick, B., Varella-Garcia, M., Bunn, P. A., Hirsch, F. R.

“…Abstract only e14566 Background: We previously demonstrated the synergistic effect of the histone deacetylase inhibitor SNDX-275 and gefitinib in non-small…”
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Insulin-like growth factor receptor 1 (IGF1R) protein expression, mRNA expression and gene copy number in operable non-small cell lung cancer (NSCLC) by Dziadziuszko, R., Merrick, D. T., Witta, S. E., Mendoza, A. D., Szostakiewicz, B., Rzyman, W., Jassem, J., Bunn, P. A., Varella-Garcia, M., Hirsch, F. R.

“…Abstract only 7524 Background: IGF1R is a promising target for NSCLC therapy. We have evaluated IGF1R protein expression, mRNA expression and gene copy number…”
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Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines by Witta, Samir E, Gemmill, Robert M, Hirsch, Fred R, Coldren, Christopher D, Hedman, Karla, Ravdel, Larisa, Helfrich, Barbara, Dziadziuszko, Rafal, Chan, Daniel C, Sugita, Michio, Chan, Zeng, Baron, Anna, Franklin, Wilbur, Drabkin, Harry A, Girard, Luc, Gazdar, Adi F, Minna, John D, Bunn, Jr, Paul A

“…The epidermal growth factor receptor (EGFR) is overexpressed in the majority of non-small cell lung cancers (NSCLC). EGFR tyrosine kinase inhibitors, such as…”
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Predicting clinical benefit from EGFR TKIs: Not all EGFR mutations are equal by Hirsch, F. R., Franklin, W. A., McCoy, J., Cappuzzo, F., Varella-Garcia, M., Witta, S. E., Gumerlock, P., West, H., Gandara, D. R., Bunn, P. A.

“…Abstract only 7072 Background: EGFR mutations are associated with better response and in some studies (mainly Asian) also with prolonged survival after…”
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Overcoming resistance to EGFR inhibitors in NSCLC cell lines by sequential treatment with histone deacetylase inhibitors by Witta, S. E., Helfrich, B., Chan, D., Hirsch, F., Franklin, W., Drabkin, H. A., Gemmill, R. M., Bunn, P. A.

“…Abstract only…”
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Defining gefitinib sensitivity/resistance in non-small cell lung cancer (NSCLC) cell lines by affymetrix gene arrays by Hirsch, F. R., Franklin, W. A., Witta, S. E., Helfrich, B., Lapadat, R., Coldren, C. D., Sugita, M., Bunn, P. A.

“…Abstract only…”
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Defining gefitinib sensitivity/resistance in non-small cell lung cancer (NSCLC) cell lines by affymetrix gene arrays by Hirsch, F. R., Franklin, W. A., Witta, S. E., Helfrich, B., Lapadat, R., Coldren, C. D., Sugita, M., Bunn, P. A.

“…Abstract only…”
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Characterization of the Bex gene family in humans, mice, and rats by Alvarez, Enrique, Zhou, Wenbo, Witta, Samir E., Freed, Curt R.

“…To better understand the development of ventral mesencephalic dopamine neurons, we performed subtractive hybridization screens to find ventral mesencephalic…”
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A Phase I and Pharmacokinetic Study of Exisulind and Docetaxel in Patients with Advanced Solid Tumors by WITTA, Samir E, GUSTAFSON, Daniel L, LONG, Michael E, GIBBS, Amy, KELLY, Karen, BUNN, Paul A, CHAN, Daniel C, PALLANSCH, Patrick, ECKHARDT, S. Gail, PIERSON, A. Scott, MENTER, Alexander, HOLDEN, Scott N, BASCHE, Michele, PERSKY, Martha, O'BRYANT, Cindy L, CHAN ZENG, BARON, Anna

“…Purpose: Exisulind (sulindac sulfone, FGN-1, Aptosyn) is a sulindac metabolite that induces apoptosis via inhibition of cyclic GMP-phosphodiesterase. This…”
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XlPOU 2 is a potential regulator of Spemann’s Organizer by Witta, Samir E., Sato, Sheryl M.

“…ABSTRACT XlPOU 2, a member of the class III POU-domain family, is expressed initially at mid-blastula transition (MBT) and during gastrulation in the entire…”
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