Search Results - "Witt, Olaf"

HDAC8: a multifaceted target for therapeutic interventions by Chakrabarti, Alokta, Oehme, Ina, Witt, Olaf, Oliveira, Guilherme, Sippl, Wolfgang, Romier, Christophe, Pierce, Raymond J, Jung, Manfred

“…Highlights • HDAC8, a unique class I HDAC, recognizes both histone and nonhistone substrates. • HDAC8 is implicated in cancer, schistosomiasis, and Cornelia de…”
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HDAC family: What are the cancer relevant targets? by Witt, Olaf, Deubzer, Hedwig E, Milde, Till, Oehme, Ina

“…Abstract Histone deacetylases comprise a family of 18 genes, which are grouped into classes I–IV based on their homology to their respective yeast orthologues…”
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Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience by Capper, David, Stichel, Damian, Sahm, Felix, Jones, David T. W., Schrimpf, Daniel, Sill, Martin, Schmid, Simone, Hovestadt, Volker, Reuss, David E., Koelsche, Christian, Reinhardt, Annekathrin, Wefers, Annika K., Huang, Kristin, Sievers, Philipp, Ebrahimi, Azadeh, Schöler, Anne, Teichmann, Daniel, Koch, Arend, Hänggi, Daniel, Unterberg, Andreas, Platten, Michael, Wick, Wolfgang, Witt, Olaf, Milde, Till, Korshunov, Andrey, Pfister, Stefan M., von Deimling, Andreas

“…Recently, we described a machine learning approach for classification of central nervous system tumors based on the analysis of genome-wide DNA methylation…”
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Risk stratification of childhood medulloblastoma in the molecular era: the current consensus by Ramaswamy, Vijay, Remke, Marc, Bouffet, Eric, Bailey, Simon, Clifford, Steven C., Doz, Francois, Kool, Marcel, Dufour, Christelle, Vassal, Gilles, Milde, Till, Witt, Olaf, von Hoff, Katja, Pietsch, Torsten, Northcott, Paul A., Gajjar, Amar, Robinson, Giles W., Padovani, Laetitia, André, Nicolas, Massimino, Maura, Pizer, Barry, Packer, Roger, Rutkowski, Stefan, Pfister, Stefan M., Taylor, Michael D., Pomeroy, Scott L.

“…Historical risk stratification criteria for medulloblastoma rely primarily on clinicopathological variables pertaining to age, presence of metastases, extent…”
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DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats by Brocks, David, Schmidt, Christopher R, Daskalakis, Michael, Jang, Hyo Sik, Shah, Nakul M, Li, Daofeng, Li, Jing, Zhang, Bo, Hou, Yiran, Laudato, Sara, Lipka, Daniel B, Schott, Johanna, Bierhoff, Holger, Assenov, Yassen, Helf, Monika, Ressnerova, Alzbeta, Islam, Md Saiful, Lindroth, Anders M, Haas, Simon, Essers, Marieke, Imbusch, Charles D, Brors, Benedikt, Oehme, Ina, Witt, Olaf, Lübbert, Michael, Mallm, Jan-Philipp, Rippe, Karsten, Will, Rainer, Weichenhan, Dieter, Stoecklin, Georg, Gerhäuser, Clarissa, Oakes, Christopher C, Wang, Ting, Plass, Christoph

“…Christoph Plass and colleagues investigate the transcriptomic and epigenomic changes induced by treatment with inhibitors of DNMT and HDAC in cancer cell…”
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Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas by Bender, Sebastian, Tang, Yujie, Lindroth, Anders M., Hovestadt, Volker, Jones, David T.W., Kool, Marcel, Zapatka, Marc, Northcott, Paul A., Sturm, Dominik, Wang, Wei, Radlwimmer, Bernhard, Højfeldt, Jonas W., Truffaux, Nathalène, Castel, David, Schubert, Simone, Ryzhova, Marina, Şeker-Cin, Huriye, Gronych, Jan, Johann, Pascal David, Stark, Sebastian, Meyer, Jochen, Milde, Till, Schuhmann, Martin, Ebinger, Martin, Monoranu, Camelia-Maria, Ponnuswami, Anitha, Chen, Spenser, Jones, Chris, Witt, Olaf, Collins, V. Peter, von Deimling, Andreas, Jabado, Nada, Puget, Stephanie, Grill, Jacques, Helin, Kristian, Korshunov, Andrey, Lichter, Peter, Monje, Michelle, Plass, Christoph, Cho, Yoon-Jae, Pfister, Stefan M.

“…Two recurrent mutations, K27M and G34R/V, within histone variant H3.3 were recently identified in ∼50% of pHGGs. Both mutations define clinically and…”
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Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing by Hovestadt, Volker, Jones, David T. W., Picelli, Simone, Wang, Wei, Kool, Marcel, Northcott, Paul A., Sultan, Marc, Stachurski, Katharina, Ryzhova, Marina, Warnatz, Hans-Jörg, Ralser, Meryem, Brun, Sonja, Bunt, Jens, Jäger, Natalie, Kleinheinz, Kortine, Erkek, Serap, Weber, Ursula D., Bartholomae, Cynthia C., von Kalle, Christof, Lawerenz, Chris, Eils, Jürgen, Koster, Jan, Versteeg, Rogier, Milde, Till, Witt, Olaf, Schmidt, Sabine, Wolf, Stephan, Pietsch, Torsten, Rutkowski, Stefan, Scheurlen, Wolfram, Taylor, Michael D., Brors, Benedikt, Felsberg, Jörg, Reifenberger, Guido, Borkhardt, Arndt, Lehrach, Hans, Wechsler-Reya, Robert J., Eils, Roland, Yaspo, Marie-Laure, Landgraf, Pablo, Korshunov, Andrey, Zapatka, Marc, Radlwimmer, Bernhard, Pfister, Stefan M., Lichter, Peter

“…Medulloblastoma is a malignant childhood brain tumour presenting major clinical challenges; here, a comprehensive genome-wide DNA methylation data set from…”
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Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma by Brockmann, Markus, Poon, Evon, Berry, Teeara, Carstensen, Anne, Deubzer, Hedwig E., Rycak, Lukas, Jamin, Yann, Thway, Khin, Robinson, Simon P., Roels, Frederik, Witt, Olaf, Fischer, Matthias, Chesler, Louis, Eilers, Martin

“…Amplification of MYCN is a driver mutation in a subset of human neuroendocrine tumors, including neuroblastoma. No small molecules that target N-Myc, the…”
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Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial by Franz, David Neal, Prof, Belousova, Elena, MD, Sparagana, Steven, MD, Bebin, E Martina, MD, Frost, Michael, MD, Kuperman, Rachel, MD, Witt, Olaf, MD, Kohrman, Michael H, MD, Flamini, J Robert, MD, Wu, Joyce Y, MD, Curatolo, Paolo, Prof, de Vries, Petrus J, Prof, Whittemore, Vicky H, PhD, Thiele, Elizabeth A, MD, Ford, James P, MS, Shah, Gaurav, MD, Cauwel, Helene, MSc, Lebwohl, David, MD, Sahmoud, Tarek, MD, Jozwiak, Sergiusz, MD

“…Summary Background Tuberous sclerosis complex is a genetic disorder leading to constitutive activation of mammalian target of rapamycin (mTOR) and growth of…”
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Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors by Senger, Johanna, Melesina, Jelena, Marek, Martin, Romier, Christophe, Oehme, Ina, Witt, Olaf, Sippl, Wolfgang, Jung, Manfred

“…Histone deacetylase 6 (HDAC6) catalyzes the removal of an acetyl group from lysine residues of several non-histone proteins. Here we report the preparation of…”
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Long-Term Use of Everolimus in Patients with Tuberous Sclerosis Complex: Final Results from the EXIST-1 Study by Franz, David N, Belousova, Elena, Sparagana, Steven, Bebin, E Martina, Frost, Michael D, Kuperman, Rachel, Witt, Olaf, Kohrman, Michael H, Flamini, J Robert, Wu, Joyce Y, Curatolo, Paolo, de Vries, Petrus J, Berkowitz, Noah, Niolat, Julie, Jóźwiak, Sergiusz

“…Everolimus, a mammalian target of rapamycin (mTOR) inhibitor, has demonstrated efficacy in treating subependymal giant cell astrocytomas (SEGAs) and other…”
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A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR by Sievers, Philipp, Sill, Martin, Schrimpf, Daniel, Stichel, Damian, Reuss, David E, Sturm, Dominik, Hench, Jürgen, Frank, Stephan, Krskova, Lenka, Vicha, Ales, Zapotocky, Michal, Bison, Brigitte, Castel, David, Grill, Jacques, Debily, Marie-Anne, Harter, Patrick N, Snuderl, Matija, Kramm, Christof M, Reifenberger, Guido, Korshunov, Andrey, Jabado, Nada, Wesseling, Pieter, Wick, Wolfgang, Solomon, David A, Perry, Arie, Jacques, Thomas S, Jones, Chris, Witt, Olaf, Pfister, Stefan M, von Deimling, Andreas, Jones, David T W, Sahm, Felix

“…Abstract Background Malignant astrocytic gliomas in children show a remarkable biological and clinical diversity. Small in-frame insertions or missense…”
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Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets by Sahm, Felix, Schrimpf, Daniel, Jones, David T. W., Meyer, Jochen, Kratz, Annekathrin, Reuss, David, Capper, David, Koelsche, Christian, Korshunov, Andrey, Wiestler, Benedikt, Buchhalter, Ivo, Milde, Till, Selt, Florian, Sturm, Dominik, Kool, Marcel, Hummel, Manuela, Bewerunge-Hudler, Melanie, Mawrin, Christian, Schüller, Ulrich, Jungk, Christine, Wick, Antje, Witt, Olaf, Platten, Michael, Herold-Mende, Christel, Unterberg, Andreas, Pfister, Stefan M., Wick, Wolfgang, von Deimling, Andreas

“…With the number of prognostic and predictive genetic markers in neuro-oncology steadily growing, the need for comprehensive molecular analysis of…”
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MAPK pathway activation in pilocytic astrocytoma by Jones, David T. W., Gronych, Jan, Lichter, Peter, Witt, Olaf, Pfister, Stefan M.

“…Pilocytic astrocytoma (PA) is the most common tumor of the pediatric central nervous system (CNS). A body of research over recent years has demonstrated a key…”
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Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome by Hartlieb, Sabine A., Sieverling, Lina, Nadler-Holly, Michal, Ziehm, Matthias, Toprak, Umut H., Herrmann, Carl, Ishaque, Naveed, Okonechnikov, Konstantin, Gartlgruber, Moritz, Park, Young-Gyu, Wecht, Elisa Maria, Savelyeva, Larissa, Henrich, Kai-Oliver, Rosswog, Carolina, Fischer, Matthias, Hero, Barbara, Jones, David T. W., Pfaff, Elke, Witt, Olaf, Pfister, Stefan M., Volckmann, Richard, Koster, Jan, Kiesel, Katharina, Rippe, Karsten, Taschner-Mandl, Sabine, Ambros, Peter, Brors, Benedikt, Selbach, Matthias, Feuerbach, Lars, Westermann, Frank

“…Telomere maintenance by telomerase activation or alternative lengthening of telomeres (ALT) is a major determinant of poor outcome in neuroblastoma. Here, we…”
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Histone Deacetylase 8 in Neuroblastoma Tumorigenesis by Oehme, Ina, Deubzer, Hedwig E, Wegener, Dennis, Pickert, Diana, Linke, Jan-Peter, Hero, Barbara, Kopp-Schneider, Annette, Westermann, Frank, Ulrich, Scott M, von Deimling, Andreas, Fischer, Matthias, Witt, Olaf

“…Purpose: The effects of pan–histone deacetylase (HDAC) inhibitors on cancer cells have shown that HDACs are involved in fundamental tumor biological processes…”
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Safety and efficacy of mTOR inhibitor treatment in patients with tuberous sclerosis complex under 2 years of age - a multicenter retrospective study by Saffari, Afshin, Brösse, Ines, Wiemer-Kruel, Adelheid, Wilken, Bernd, Kreuzaler, Paula, Hahn, Andreas, Bernhard, Matthias K, van Tilburg, Cornelis M, Hoffmann, Georg F, Gorenflo, Matthias, Hethey, Sven, Kaiser, Olaf, Kölker, Stefan, Wagner, Robert, Witt, Olaf, Merkenschlager, Andreas, Möckel, Andreas, Roser, Timo, Schlump, Jan-Ulrich, Serfling, Antje, Spiegler, Juliane, Milde, Till, Ziegler, Andreas, Syrbe, Steffen

“…Tuberous sclerosis complex (TSC) is a multisystem disease with prominent neurologic manifestations such as epilepsy, cognitive impairment and autism spectrum…”
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Histone deacetylase 10 promotes autophagy-mediated cell survival by Oehme, Ina, Linke, Jan-Peter, Böck, Barbara C, Milde, Till, Lodrini, Marco, Hartenstein, Bettina, Wiegand, Inga, Eckert, Christian, Roth, Wilfried, Kool, Marcel, Kaden, Sylvia, Gröne, Hermann-Josef, Schulte, Johannes H, Lindner, Sven, Hamacher-Brady, Anne, Brady, Nathan R, Deubzer, Hedwig E, Witt, Olaf

“…Tumor cells activate autophagy in response to chemotherapy-induced DNA damage as a survival program to cope with metabolic stress. Here, we provide in vitro…”
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Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation by Erkek, Serap, Johann, Pascal D., Finetti, Martina A., Drosos, Yiannis, Chou, Hsien-Chao, Zapatka, Marc, Sturm, Dominik, Jones, David T.W., Korshunov, Andrey, Rhyzova, Marina, Wolf, Stephan, Mallm, Jan-Philipp, Beck, Katja, Witt, Olaf, Kulozik, Andreas E., Frühwald, Michael C., Northcott, Paul A., Korbel, Jan O., Lichter, Peter, Eils, Roland, Gajjar, Amar, Roberts, Charles W.M., Williamson, Daniel, Hasselblatt, Martin, Chavez, Lukas, Pfister, Stefan M., Kool, Marcel

“…Biallelic inactivation of SMARCB1, encoding a member of the SWI/SNF chromatin remodeling complex, is the hallmark genetic aberration of atypical teratoid…”
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Targeting histone deacetylase 8 as a therapeutic approach to cancer and neurodegenerative diseases by Chakrabarti, Alokta, Melesina, Jelena, Kolbinger, Fiona R, Oehme, Ina, Senger, Johanna, Witt, Olaf, Sippl, Wolfgang, Jung, Manfred

“…Histone deacetylase 8 (HDAC8), a unique class I zinc-dependent HDAC, is an emerging target in cancer and other diseases. Its substrate repertoire extends…”
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