Search Results - "Witt, Kristine"

Meta-analysis of chromosomal aberrations as a biomarker of exposure in healthcare workers occupationally exposed to antineoplastic drugs by Roussel, Christine, Witt, Kristine L., Shaw, Peter B., Connor, Thomas H.

“…Many antineoplastic drugs used to treat cancer, particularly alkylating agents and topoisomerase inhibitors, are known to induce genetic damage in patients…”
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Next generation high throughput DNA damage detection platform for genotoxic compound screening by Sykora, Peter, Witt, Kristine L., Revanna, Pooja, Smith-Roe, Stephanie L., Dismukes, Jonathan, Lloyd, Donald G., Engelward, Bevin P., Sobol, Robert W.

“…Methods for quantifying DNA damage, as well as repair of that damage, in a high-throughput format are lacking. Single cell gel electrophoresis (SCGE; comet…”
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Within‐laboratory reproducibility of Ames test results: Are repeat tests necessary? by Zeiger, Errol, Mitchell, Constance A., Pfuhler, Stefan, Liao, Yang, Witt, Kristine L.

“…The Ames test is required by regulatory agencies worldwide for assessing the mutagenic and carcinogenic potential of chemical compounds. This test uses several…”
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The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells by Li, Xilin, He, Xiaobo, Chen, Si, Le, Yuan, Bryant, Matthew S., Guo, Lei, Witt, Kristine L., Mei, Nan

“…[Display omitted] •Luteolin induces concentration-dependent cytotoxicity and genotoxicity in TK6 cells.•Luteolin-induced toxicity is enhanced in the TK6 cells…”
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The in vivo Pig-a assay: A report of the International Workshop On Genotoxicity Testing (IWGT) Workgroup by Gollapudi, B. Bhaskar, Lynch, Anthony M., Heflich, Robert H., Dertinger, Stephen D., Dobrovolsky, Vasily N., Froetschl, Roland, Horibata, Katsuyoshi, Kenyon, Michelle O., Kimoto, Takafumi, Lovell, David P., Stankowski, Leon F., White, Paul A., Witt, Kristine L., Tanir, Jennifer Y.

“…•An IWGT Workgroup reviewed the in vivo Pig-a assay as a safety assessment tool.•Data for 41 agents evaluated in the rat Pig-a assay were…”
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In vivo genotoxicity testing strategies: Report from the 8th International Workshop on Genotoxicity Testing (IWGT) by Beevers, Carol, Uno, Yoshifumi, Meurer, Krista, Hamada, Shuichi, Hashimoto, Kiyohiro, Kirkland, David, LeBaron, Matthew J, Le Curieux, Frank, Le Hegarat, Ludovic, Martus, Hans-Joerg, Masumura, Kenichi, Ohyama, Wakako, Roberts, Daniel J, Vasquez, Marie, Whitwell, James, Witt, Kristine L

“…The in vivo working group (WG) considered three topics: acceptable maximum doses for negative erythrocyte micronucleus (MN) tests, validation status of MN…”
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Identification of Compounds That Inhibit Estrogen-Related Receptor Alpha Signaling Using High-Throughput Screening Assays by Lynch, Caitlin, Zhao, Jinghua, Sakamuru, Srilatha, Zhang, Li, Huang, Ruili, Witt, Kristine L, Merrick, B Alex, Teng, Christina T, Xia, Menghang

“…The nuclear receptor, estrogen-related receptor alpha (ERRα; NR3B1), plays a pivotal role in energy homeostasis. Its expression fluctuates with the demands of…”
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Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential by Attene-Ramos, Matias S, Huang, Ruili, Michael, Sam, Witt, Kristine L, Richard, Ann, Tice, Raymond R, Simeonov, Anton, Austin, Christopher P, Xia, Menghang

“…Mitochondrial dysfunction has been implicated in the pathogenesis of a variety of disorders including cancer, diabetes, and neurodegenerative and…”
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Investigating the Generalizability of the MultiFlow ® DNA Damage Assay and Several Companion Machine Learning Models With a Set of 103 Diverse Test Chemicals by Bryce, Steven M, Bernacki, Derek T, Smith-Roe, Stephanie L, Witt, Kristine L, Bemis, Jeffrey C, Dertinger, Stephen D

“…Abstract The in vitro MultiFlow DNA Damage assay multiplexes p53, γH2AX, phospho-histone H3, and polyploidization biomarkers into 1 flow cytometric analysis…”
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Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors by Huang, Ruili, Xia, Menghang, Cho, Ming-Hsuang, Sakamuru, Srilatha, Shinn, Paul, Houck, Keith A., Dix, David J., Judson, Richard S., Witt, Kristine L., Kaylock, Robert J., Tice, Raymond R., Austin, Christopher P.

“…Background: The large and increasing number of chemicals released into the environment demands more efficient and cost-effective approaches for assessing…”
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Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway by Huang, Ruili, Sakamuru, Srilatha, Martin, Matt T., Reif, David M., Judson, Richard S., Houck, Keith A., Casey, Warren, Hsieh, Jui-Hua, Shockley, Keith R., Ceger, Patricia, Fostel, Jennifer, Witt, Kristine L., Tong, Weida, Rotroff, Daniel M., Zhao, Tongan, Shinn, Paul, Simeonov, Anton, Dix, David J., Austin, Christopher P., Kavlock, Robert J., Tice, Raymond R., Xia, Menghang

“…The U.S. Tox21 program has screened a library of approximately 10,000 (10K) environmental chemicals and drugs in three independent runs for estrogen receptor…”
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Identification of environmental chemicals that activate p53 signaling after in vitro metabolic activation by Ooka, Masato, Zhao, Jinghua, Shah, Pranav, Travers, Jameson, Klumpp-Thomas, Carleen, Xu, Xin, Huang, Ruili, Ferguson, Stephen, Witt, Kristine L., Smith-Roe, Stephanie L., Simeonov, Anton, Xia, Menghang

“…Currently, approximately 80,000 chemicals are used in commerce. Most have little-to-no toxicity information. The U.S. Toxicology in the 21st Century (Tox21)…”
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Development and Application of TK6-derived Cells Expressing Human Cytochrome P450s for Genotoxicity Testing by Li, Xilin, Chen, Si, Guo, Xiaoqing, Wu, Qiangen, Seo, Ji-Eun, Guo, Lei, Manjanatha, Mugimane G, Zhou, Tong, Witt, Kristine L, Mei, Nan

“…Abstract Metabolism plays a key role in chemical genotoxicity; however, most mammalian cells used for in vitro genotoxicity testing lack effective metabolizing…”
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Dose-response assessment of four genotoxic chemicals in a combined mouse and rat micronucleus (MN) and Comet assay protocol by Recio, Leslie, Hobbs, Cheryl, Caspary, William, Witt, Kristine L.

“…The in vivo micronucleus (MN) assay has proven to be an effective measure of genotoxicity potential. However, sampling a single tissue (bone marrow) for a…”
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Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines by Li, Xilin, He, Xiaobo, Chen, Si, Guo, Xiaoqing, Bryant, Matthew S., Guo, Lei, Manjanatha, Mugimane G., Zhou, Tong, Witt, Kristine L., Mei, Nan

“…Pyrrolizidine alkaloid (PA)-containing plants are among the most common poisonous plants affecting humans, livestock, and wildlife worldwide. A large number of…”
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Identification of Environmental Compounds That May Trigger Early Female Puberty by Activating Human GnRHR and KISS1R by Yang, Shu, Zhang, Li, Khan, Kamal, Travers, Jameson, Huang, Ruili, Jovanovic, Vukasin M, Veeramachaneni, Rithvik, Sakamuru, Srilatha, Tristan, Carlos A, Davis, Erica E, Klumpp-Thomas, Carleen, Witt, Kristine L, Simeonov, Anton, Shaw, Natalie D, Xia, Menghang

“…Abstract There has been an alarming trend toward earlier puberty in girls, suggesting the influence of an environmental factor(s). As the reactivation of the…”
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Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing by Marchetti, Francesco, Cardoso, Renato, Chen, Connie L., Douglas, George R., Elloway, Joanne, Escobar, Patricia A., Harper Jr, Tod, Heflich, Robert H., Kidd, Darren, Lynch, Anthony M., Myers, Meagan B., Parsons, Barbara L., Salk, Jesse J., Settivari, Raja S., Smith-Roe, Stephanie L., Witt, Kristine L., Yauk, Carole, Young, Robert R., Zhang, Shaofei, Minocherhomji, Sheroy

“…Error-corrected next-generation sequencing (ecNGS) is an emerging technology with the potential to revolutionize the field of genetic toxicology. Here, we…”
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Evaluation of the genotoxicity of cell phone radiofrequency radiation in male and female rats and mice following subchronic exposure by Smith‐Roe, Stephanie L., Wyde, Michael E., Stout, Matthew D., Winters, John W., Hobbs, Cheryl A., Shepard, Kim G., Green, Amanda S., Kissling, Grace E., Shockley, Keith R., Tice, Raymond R., Bucher, John R., Witt, Kristine L.

“…The National Toxicology Program tested two common radiofrequency radiation (RFR) modulations emitted by cellular telephones in a 2‐year rodent cancer bioassay…”
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Mutation as a Toxicological Endpoint for Regulatory Decision‐Making by Heflich, Robert H., Johnson, George E., Zeller, Andreas, Marchetti, Francesco, Douglas, George R., Witt, Kristine L., Gollapudi, B. Bhaskar, White, Paul A.

“…Mutations induced in somatic cells and germ cells are responsible for a variety of human diseases, and mutation per se has been considered an adverse health…”
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Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies by Xia, Menghang, Huang, Ruili, Shi, Qiang, Boyd, Windy A, Zhao, Jinghua, Sun, Nuo, Rice, Julie R, Dunlap, Paul E, Hackstadt, Amber J, Bridge, Matt F, Smith, Marjolein V, Dai, Sheng, Zheng, Wei, Chu, Pei-Hsuan, Gerhold, David, Witt, Kristine L, DeVito, Michael, Freedman, Jonathan H, Austin, Christopher P, Houck, Keith A, Thomas, Russell S, Paules, Richard S, Tice, Raymond R, Simeonov, Anton

“…A central challenge in toxicity testing is the large number of chemicals in commerce that lack toxicological assessment. In response, the Tox21 program is…”
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