Search Results - "Witt, Alexander"

Getting the best outcomes from epilepsy surgery by Vakharia, Vejay N., Duncan, John S., Witt, Juri‐Alexander, Elger, Christian E., Staba, Richard, Engel, Jerome

“…Neurosurgery is an underutilized treatment that can potentially cure drug‐refractory epilepsy. Careful, multidisciplinary presurgical evaluation is vital for…”
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Adverse cognitive effects of antiepileptic pharmacotherapy: Each additional drug matters by Witt, Juri-Alexander, Elger, Christian E, Helmstaedter, Christoph

“…Abstract The study was set up to evaluate the impact of the total drug load of antiepileptic pharmacotherapy on cognition. Retrospective analyses were based on…”
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Cognition in epilepsy: current clinical issues of interest by Witt, Juri-Alexander, Helmstaedter, Christoph

“…This review provides an update and summary of recent neuropsychological findings in epilepsy focusing on three major clinical topics among the many…”
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Neuropathological Insights into Unexpected Cognitive Decline in Epilepsy by Reimers, Annika, Helmstaedter, Christoph, Elger, Christian E., Pitsch, Julika, Hamed, Motaz, Becker, Albert J., Witt, Juri‐Alexander

“…Objective Some patients unexpectedly display an unfavorable cognitive course after epilepsy surgery subsequent to any direct cognitive sequelae of the surgical…”
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Evaluating the mediating role of executive functions for antiepileptic drugs' effects on IQ in children and adolescents with epilepsy by Helmstaedter, Christoph, Witt, Juri-Alexander, Hoppe, Christian

“…Several studies suggest that antiepileptic drug (AED) treatment may permanently or reversibly affect intelligence (intelligence quotient [IQ]) in children and…”
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Unjustified allegation on cancer risks in children of mothers with epilepsy taking high-dose folic acid during pregnancy-No proof of a causal relationship by von Wrede, Randi, Witt, Juri-Alexander, Auvin, Stéphane, Devlin, Anita, Lagae, Lieven, Marson, Anthony, Meador, Kimford J, O'Brien, Terence J, Park, Jun, Surges, Rainer, Trinka, Eugen, Wiebe, Samuel, Helmstaedter, Christoph

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Changes in cognition after introduction or withdrawal of zonisamide versus topiramate in epilepsy patients: A retrospective study using Bayes statistics by Meschede, Carolin, Witt, Juri‐Alexander, Brömling, Sarah, Moskau‐Hartmann, Susanna, Rademacher, Michael, Surges, Rainer, Wrede, Randi, Helmstaedter, Christoph

“…Objective We aim to evaluate the impact of zonisamide (ZNS) compared to topiramate (TPM) on cognition in patients with epilepsy. Although the risk of cognitive…”
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Evidence for interictal blood–brain barrier dysfunction in people with epilepsy by Reiter, Johannes T., Schulte, Freya, Bauer, Tobias, David, Bastian, Endler, Christoph, Isaak, Alexander, Schuch, Fabiane, Bitzer, Felix, Witt, Juri‐Alexander, Hattingen, Elke, Deichmann, Ralf, Attenberger, Ulrike, Becker, Albert J., Helmstaedter, Christoph, Radbruch, Alexander, Surges, Rainer, Friedman, Alon, Rüber, Theodor

“…Objective Interictal blood–brain barrier dysfunction in chronic epilepsy has been demonstrated in animal models and pathological specimens. Ictal blood–brain…”
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Does the accumulated antiepileptic drug load in chronic epilepsy reflect disease severity? by Witt, Juri‐Alexander, Nass, Robert D., Baumgartner, Tobias, Wrede, Randi, Elger, Christian E., Surges, Rainer, Helmstaedter, Christoph

“…Objective To ascertain factors that are related to the antiepileptic drug load in epilepsy. Methods In this cross‐sectional study, we analyzed a large cohort…”
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Cognition in the early stages of adult epilepsy by Witt, Juri-Alexander, Helmstaedter, Christoph

“…Highlights • Cognitive impairment represents a major comorbidity of epilepsy. • Studies in new-onset epilepsies indicate impairment already at epilepsy onset…”
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Multifactorial etiology of interictal behavior in frontal and temporal lobe epilepsy by Helmstaedter, Christoph, Witt, Juri-Alexander

“…Summary Purpose:  Based on discussions on the so called “epileptic personality” in patients with epilepsy, interictal behavioral impairments in frontal and…”
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Screening for depression in patients with epilepsy: What are the benefits for physicians and patients in the real‐life setting by Wrede, Randi, Witt, Juri‐Alexander, Jessen, Nina, Lossius, Morten I., Moskau‐Hartmann, Susanna, Helmstaedter, Christoph

“…Objective Screening for depression in people with epilepsy (PWE) is highly recommended in order to avoid underdiagnosis, misdiagnosis, or delayed diagnosis of…”
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The immediate and short‐term effects of bilateral intrahippocampal depth electrodes on verbal memory by Helmstaedter, Christoph, Gielen, Gerrit H., Witt, Juri‐Alexander

“…Summary In contrast to previous studies, Ljung et al. provide evidence of permanent cognitive consequences of bilateral intrahippocampal depth electrodes for…”
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Laser interstitial thermotherapy (LiTT) in epilepsy surgery by Hoppe, Christian, Witt, Juri-Alexander, Helmstaedter, Christoph, Gasser, Thomas, Vatter, Hartmut, Elger, Christian E

“…Highlights • Stereotactic laser thermocoagulation (SLT) is now introduced to epilepsy surgery. • SLT provides minimally invasive destruction of pathogenic soft…”
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Specific B- and T-cell populations are associated with cognition in patients with epilepsy and antibody positive and negative suspected limbic encephalitis by Helmstaedter, Christoph, Hansen, Niels, Leelaarporn, Pitshaporn, Schwing, Kerstin, Oender, Demet, Widman, Guido, Racz, Attila, Surges, Rainer, Becker, Albert, Witt, Juri-Alexander

“…Objective Neuropsychological impairments are major symptoms of autoimmune limbic encephalitis (LE) epilepsy patients. In LE epilepsy patients with an…”
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Reversible Photoswitching of a Spin-Crossover Molecular Complex in the Solid State at Room Temperature by Rösner, Benedikt, Milek, Magdalena, Witt, Alexander, Gobaut, Benoît, Torelli, Piero, Fink, Rainer H., Khusniyarov, Marat M.

“…Spin‐crossover metal complexes are highly promising magnetic molecular switches for prospective molecule‐based devices. The spin‐crossover molecular…”
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Accelerated long-term forgetting in focal epilepsies with special consideration given to patients with diagnosed and suspected limbic encephalitis by Helmstaedter, Christoph, Winter, Babette, Melzer, Nico, Lohmann, Hubertus, Witt, Juri-Alexander

“…Accelerated long-term forgetting (ALF) is a phenomenon found in late onset epilepsy and in transient epileptic amnesia (TEA). Here we evaluated ALF in patients…”
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A novel geometry‐based analysis of hippocampal morphometry in mesial temporal lobe epilepsy by Fischbach, Laura, Bauer, Tobias, Diers, Kersten, Witt, Juri‐Alexander, Brugues, Mar, Borger, Valeri, Schidlowski, Martin, Rácz, Attila, Baumgartner, Tobias, Wrede, Randi, Paech, Daniel, Weber, Bernd, Radbruch, Alexander, Vatter, Hartmut, Becker, Albert J., Huppertz, Hans‐Jürgen, Helmstaedter, Christoph, Surges, Rainer, Reuter, Martin, Rüber, Theodor

“…Hippocampal volumetry is an essential tool in researching and diagnosing mesial temporal lobe epilepsy (mTLE). However, it has a limited ability to detect…”
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The multifactorial etiology of cognitive deficits in epilepsy and the neuropathology of mesial temporal lobe epilepsy beyond hyperphosphorylated tau by Witt, Juri‐Alexander, Becker, Albert J., Helmstaedter, Christoph

“…In response to the recent review by Zawar and Kapur on the overlap between mesial temporal lobe epilepsy (MTLE) and Alzheimer's disease (AD), we (1) underscore…”
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The effect of quantitative and qualitative antiepileptic drug changes on cognitive recovery after epilepsy surgery by Helmstaedter, Christoph, PhD, Elger, Christian Erich, MD, Witt, Juri-Alexander, PhD

“…Highlights • Epilepsy surgery can cause cognitive decline and improvement as well. • Neuropsychological outcome depends on surgery, seizure control, and drug…”
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