Search Results - "Witola, William"

Past, current, and potential treatments for cryptosporidiosis in humans and farm animals: A comprehensive review by Khan, Shahbaz M, Witola, William H

“…The intracellular protozoan parasite of the genus is among the leading causes of waterborne diarrheal disease outbreaks throughout the world. The parasite is…”
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Mendelian segregation and high recombination rates facilitate genetic analyses in Cryptosporidium parvum by Kimball, Abigail, Funkhouser-Jones, Lisa, Huang, Wanyi, Xu, Rui, Witola, William H, Sibley, L David

“…Very little is known about the process of meiosis in the apicomplexan parasite Cryptosporidium despite the essentiality of sex in its life cycle. Most cell…”
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Selective targeting of phosphodiesterases to develop potent antiparasitic drugs by Khan, Shahbaz M., Mia, Md Mukthar, Witola, William H.

“…Regulation of intracellular cyclic nucleotides to avoid homeostatic imbalances is achieved through catabolic activity of phosphodiesterases (PDEs). Recently,…”
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Multiple pathways for glucose phosphate transport and utilization support growth of Cryptosporidium parvum by Xu, Rui, Beatty, Wandy L., Greigert, Valentin, Witola, William H., Sibley, L. David

“…Cryptosporidium parvum is an obligate intracellular parasite with a highly reduced mitochondrion that lacks the tricarboxylic acid cycle and the ability to…”
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Novel lactate dehydrogenase inhibitors with in vivo efficacy against Cryptosporidium parvum by Li, Kun, Nader, Sara M, Zhang, Xuejin, Ray, Benjamin C, Kim, Chi Yong, Das, Aditi, Witola, William H

“…Cryptosporidium parvum is a highly prevalent zoonotic and anthroponotic protozoan parasite that causes a diarrheal syndrome in children and neonatal livestock,…”
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Signal recognition particle RNA is critical for genetic competence and virulence of Streptococcus pneumoniae by Lin, Jingjun, Chong, Sook Yin, Oh, Myung Whan, Lew, Shi Qian, Zhu, Luchang, Zhang, Xuejin, Witola, William H, Lau, Gee W

“…(pneumococcus) causes a wide range of important human infectious diseases, including pneumonia, pneumonia-derived sepsis, otitis media, and meningitis…”
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Combination of inhibitors for two glycolytic enzymes portrays high synergistic efficacy against Cryptosporidium parvum by Khan, Shahbaz M., Bajwa, Muhammad Rashid, Lahar, Rachael Y., Witola, William H.

“…ABSTRACT Cryptosporidium is an intracellular protozoan parasite that causes serious enteric disease in humans and in a wide range of animals worldwide. Despite…”
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Broad-Spectrum Inhibitors for Conserved Unique Phosphoethanolamine Methyltransferases in Parasitic Nematodes Possess Anthelmintic Efficacy by Zhang, Xuejin, Sicalo Gianechini, Leonor, Li, Kun, Kaplan, Ray M, Witola, William H

“…In humans, nematode infections are prevalent in developing countries, causing long-term ill health, particularly in children. Worldwide, nematode infections…”
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Cryptosporidium parvum Pyruvate Kinase Inhibitors With in vivo Anti-cryptosporidial Efficacy by Khan, Shahbaz M, Zhang, Xuejin, Witola, William H

“…is a highly prevalent protozoan parasite that causes a diarrheal disease in humans and animals worldwide. Thus far, the moderately effective nitazoxanide is…”
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Characterization of a unique catechol-O-methyltransferase as a molecular drug target in parasitic filarial nematodes by Mia, Md Mukthar, Allaie, Idrees Mehraj, Zhang, Xuejin, Li, Kun, Khan, Shahbaz M, Kadotani, Saki, Witola, William H

“…Filarial nematodes cause severe illnesses in humans and canines including limb deformities and disfigurement, heart failure, blindness, and death, among…”
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Morpholino-mediated in vivo silencing of Cryptosporidium parvum lactate dehydrogenase decreases oocyst shedding and infectivity by Zhang, Xuejin, Kim, Chi Yong, Worthen, Tori, Witola, William H.

“…[Display omitted] •An in vivo morpholino-based approach for targeted gene knockdown of genes in Cryptosporidium parvum was developed.•Cryptosporidium parvum…”
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Small GTPase Immunity-Associated Proteins Mediate Resistance to Toxoplasma gondii Infection in Lewis Rat by Kim, Chi Yong, Zhang, Xuejin, Witola, William H

“…Rats vary in their susceptibilities to infection depending on the rat strain. Compared to the -susceptible Brown Norway (BN) rat, the Lewis (LEW) rat is…”
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Inherent Oxidative Stress in the Lewis Rat Is Associated with Resistance to Toxoplasmosis by Witola, William H, Kim, Chi Yong, Zhang, Xuejin

“…The course of infection in rats closely resembles that in humans. However, compared to the Brown Norway (BN) rat, the Lewis (LEW) rat is extremely resistant to…”
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Targeted gene knockdown validates the essential role of lactate dehydrogenase in Cryptosporidium parvum by Witola, William H., Zhang, Xuejin, Kim, Chi Yong

“…[Display omitted] •Morpholino oligomers antisense approach was developed as a reverse genetic tool in Cryptosporidium parvum.•Significant knockdown of C…”
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NALP1 Influences Susceptibility to Human Congenital Toxoplasmosis, Proinflammatory Cytokine Response, and Fate of Toxoplasma gondii-Infected Monocytic Cells by Witola, William H, Mui, Ernest, Hargrave, Aubrey, Liu, Susan, Hypolite, Magali, Montpetit, Alexandre, Cavailles, Pierre, Bisanz, Cordelia, Cesbron-Delauw, Marie-France, Fournié, Gilbert J, McLeod, Rima

“…NALP1 is a member of the NOD-like receptor (NLR) family of proteins that form inflammasomes. Upon cellular infection or stress, inflammasomes are activated,…”
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Cryptosporidium infection of human small intestinal epithelial cells induces type III interferon and impairs infectivity of Rotavirus by Greigert, Valentin, Saraav, Iti, Son, Juhee, Zhu, Yinxing, Dayao, Denise, Antia, Avan, Tzipori, Saul, Witola, William H, Stappenbeck, Thaddeus S, Ding, Siyuan, Sibley, L David

“…Cryptosporidiosis is a major cause of severe diarrheal disease in infants from resource poor settings. The majority of infections are caused by the…”
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Anti-Toxoplasma activity of Sorghum bicolor-derived lipophilic fractions by Abugri, Daniel A, Jaynes, Jesse M, Witola, William H

“…Toxoplasma gondii, an intracellular zoonotic parasite, infects approximately a third of the world population. Current drugs for treatment of T. gondii…”
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In vitro activity of the interaction between taxifolin (dihydroquercetin) and pyrimethamine against Toxoplasma gondii by Abugri, Daniel A., Witola, William H., Russell, Albert E., Troy, Roberta M.

“…Toxoplasmosis is one of the most neglected zoonotic foodborne parasitic diseases that cause public health and socioeconomic concern worldwide. The current…”
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Plasmodium falciparum phosphoethanolamine methyltransferase is essential for malaria transmission by Bobenchik, April M., Witola, William H., Augagneur, Yoann, Lochlainn, Laura Nic, Garg, Aprajita, Pachikara, Niseema, Choi, Jae-Yeon, Zhao, Yang O., Usmani-Brown, Sahar, Lee, Albert, Adjalley, Sophie H., Samanta, Swapna, Fidock, David A., Voelker, Dennis R., Fikrig, Erol, Ben Mamoun, Choukri

“…Efficient transmission of Plasmodium species between humans and Anopheles mosquitoes is a major contributor to the global burden of malaria. Gametocytogenesis,…”
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Anti-protozoal activity of Thymol and a Thymol ester against Cryptosporidium parvum in cell culture by Dominguez-Uscanga, Astrid, Aycart, Danielle Francesca, Li, Kun, Witola, William H., Andrade Laborde, Juan E.

“…Cryptosporidium parvum is a protozoan parasite that infects intestinal epithelial cells causing malabsorption and severe diarrhea. The monoterpene thymol has…”
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