Search Results - "Witkos, Tomasz M."

Recognition and tethering of transport vesicles at the Golgi apparatus by Witkos, Tomasz M, Lowe, Martin

“…Highlights • Coiled-coil golgin proteins capture transport vesicles in a specific manner. • Golgins contain vesicle tethering motifs. • Multi-subunit tethering…”
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Potency Assay Variability Estimation in Practice by Li, Hang, Witkos, Tomasz M, Umlauf, Scott, Thompson, Christopher

“…During the drug development process, testing potency plays an important role in the quality assessment required for the manufacturing and marketing of…”
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The Golgin Family of Coiled-Coil Tethering Proteins by Witkos, Tomasz M, Lowe, Martin

“…The golgins are a family of predominantly coiled-coil proteins that are localized to the Golgi apparatus. Golgins are present in all eukaryotes, suggesting an…”
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Modelling bronchial epithelial-fibroblast cross-talk in idiopathic pulmonary fibrosis (IPF) using a human-derived in vitro air liquid interface (ALI) culture by Barron, Sarah L., Wyatt, Owen, O’Connor, Andy, Mansfield, David, Suzanne Cohen, E., Witkos, Tomasz M., Strickson, Sam, Owens, Róisín M.

“…Idiopathic Pulmonary Fibrosis (IPF) is a devastating form of respiratory disease with a life expectancy of 3–4 years. Inflammation, epithelial injury and…”
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GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation by Witkos, Tomasz M., Chan, Wing Lee, Joensuu, Merja, Rhiel, Manuel, Pallister, Ed, Thomas-Oates, Jane, Mould, A. Paul, Mironov, Alex A., Biot, Christophe, Guerardel, Yann, Morelle, Willy, Ungar, Daniel, Wieland, Felix T., Jokitalo, Eija, Tassabehji, May, Kornak, Uwe, Lowe, Martin

“…COPI is a key mediator of protein trafficking within the secretory pathway. COPI is recruited to the membrane primarily through binding to Arf GTPases, upon…”
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ER sheet persistence is coupled to myosin 1c-regulated dynamic actin filament arrays by Joensuu, Merja, Belevich, Ilya, Rämö, Olli, Nevzorov, Ilya, Vihinen, Helena, Puhka, Maija, Witkos, Tomasz M, Lowe, Martin, Vartiainen, Maria K, Jokitalo, Eija

“…The endoplasmic reticulum (ER) comprises a dynamic three-dimensional (3D) network with diverse structural and functional domains. Proper ER operation requires…”
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Cooperation meets competition in microRNA-mediated DMPK transcript regulation by Koscianska, Edyta, Witkos, Tomasz M, Kozlowska, Emilia, Wojciechowska, Marzena, Krzyzosiak, Wlodzimierz J

“…The fundamental role of microRNAs (miRNAs) in the regulation of gene expression has been well-established, but many miRNA-driven regulatory mechanisms remain…”
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Sequence features of Drosha and Dicer cleavage sites affect the complexity of isomiRs by Starega-Roslan, Julia, Witkos, Tomasz M, Galka-Marciniak, Paulina, Krzyzosiak, Wlodzimierz J

“…The deep-sequencing of small RNAs has revealed that different numbers and proportions of miRNA variants called isomiRs are formed from single miRNA genes and…”
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Vimentin intermediate filaments provide structural stability to the mammalian Golgi complex by Vitali, Teresa, Sanchez-Alvarez, Rosa, Witkos, Tomasz M., Bantounas, Ioannis, Cutiongco, Marie F. A., Dudek, Michal, Yan, Guanhua, Mironov, Alexander A., Swift, Joe, Lowe, Martin

“…ABSTRACT The Golgi complex comprises a connected ribbon of stacked cisternal membranes localized to the perinuclear region in most vertebrate cells. The…”
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A potential role of extended simple sequence repeats in competing endogenous RNA crosstalk by Witkos, Tomasz M., Krzyzosiak, Wlodzimierz J., Fiszer, Agnieszka, Koscianska, Edyta

“…MicroRNA (miRNA)-mediated crosstalk between coding and non-coding RNAs of various types is known as the competing endogenous RNA (ceRNA) concept. Here, we…”
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Biochemical Analysis of Secretory Trafficking in Mammalian Cells by Roboti, Peristera, Witkos, Tomasz M., Lowe, Martin

“…Protein trafficking within the secretory pathway of mammalian cells is amenable to analysis by biochemical methods. This can be achieved by monitoring…”
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Hypomorphic mutations of TRIP11 cause odontochondrodysplasia by Wehrle, Anika, Witkos, Tomasz M, Unger, Sheila, Schneider, Judith, Follit, John A, Hermann, Johannes, Welting, Tim, Fano, Virginia, Hietala, Marja, Vatanavicharn, Nithiwat, Schoner, Katharina, Spranger, Jürgen, Schmidts, Miriam, Zabel, Bernhard, Pazour, Gregory J, Bloch-Zupan, Agnes, Nishimura, Gen, Superti-Furga, Andrea, Lowe, Martin, Lausch, Ekkehart

“…Odontochondrodysplasia (ODCD) is an unresolved genetic disorder of skeletal and dental development. Here, we show that ODCD is caused by hypomorphic TRIP11…”
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A common pathomechanism in GMAP-210- and LBR-related diseases by Wehrle, Anika, Witkos, Tomasz M, Schneider, Judith C, Hoppmann, Anselm, Behringer, Sidney, Köttgen, Anna, Elting, Mariet, Spranger, Jürgen, Lowe, Martin, Lausch, Ekkehart

“…Biallelic loss-of-function mutations in TRIP11, encoding the golgin GMAP-210, cause the lethal human chondrodysplasia achondrogenesis 1A (ACG1A). We now find…”
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Methods for Analysis of Golgi Complex Function by Perez, Franck, Stephens, David

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Biochemical Analysis of Secretory Trafficking in Mammalian Cells by Lowe, Martin, Roboti, Peristera, M. Witkos, Tomasz

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