Search Results - "Witkin, J. M"

The Rapidly Acting Antidepressant Ketamine and the mGlu2/3 Receptor Antagonist LY341495 Rapidly Engage Dopaminergic Mood Circuits by Witkin, J M, Monn, J A, Schoepp, D D, Li, X, Overshiner, C, Mitchell, S N, Carter, G, Johnson, B, Rasmussen, K, Rorick-Kehn, L M

“…Ketamine is a rapidly acting antidepressant in patients with treatment-resistant depression (TRD). Although the mechanisms underlying these effects are not…”
Get more information

Allosteric modulation of the muscarinic M₄ receptor as an approach to treating schizophrenia by Chan, W.Y, McKinzie, D.L, Bose, S, Mitchell, S.N, Witkin, J.M, Thompson, R.C, Christopoulos, A, Lazareno, S, Birdsall, N.J.M, Bymaster, F.P, Felder, C.C

“…Current antipsychotics provide symptomatic relief for patients suffering from schizophrenia and related psychoses; however, their effectiveness is variable and…”
Get full text

A role for cannabinoid CB1 receptors in mood and anxiety disorders by Witkin, J. M, Tzavara, E. T, Nomikos, G. G

“…Mood and anxiety disorders, the most prevalent of the psychiatric disorders, cause immeasurable suffering worldwide. Despite impressive advances in…”
Get full text

Obituary: J. David LEander, Ph.D. : (April 8, 1944-November 14, 2014) by Witkin, J M, Gleason, S D, Carter, R B, Dykstra, L A

Get full text

Preclinical predictors that the orthosteric mGlu2/3 receptor antagonist LY3020371 will not engender ketamine-associated neurotoxic, motor, cognitive, subjective, or abuse-liability-related effects by Witkin, J M, Monn, J A, Li, J, Johnson, B, McKinzie, D L, Wang, X-S, Heinz, B A, Li, R, Ornstein, P L, Smith, S C, Mitch, C H, Calligaro, D O, Swanson, S, Allen, D, Phillips, K, Gilmour, G

“…The novel mGlu2/3 receptor antagonist, LY3020371, has been shown to produce antidepressant-like effects comparable to that of the clinically-effective…”
Get full text

Procholinergic and memory enhancing properties of the selective norepinephrine uptake inhibitor atomoxetine by Tzavara, E T, Bymaster, F P, Overshiner, C D, Davis, R J, Perry, K W, Wolff, M, McKinzie, D L, Witkin, J M, Nomikos, G G

“…Atomoxetine has been approved by the FDA as the first new drug in 30 years for the treatment of attention deficit/hyperactivity disorder (ADHD). As a selective…”
Get full text

In vivo occupancy of dopamine D3 receptors by antagonists produces neurochemical and behavioral effects of potential relevance to attention-deficit-hyperactivity disorder by Barth, V, Need, A B, Tzavara, E T, Giros, B, Overshiner, C, Gleason, S D, Wade, M, Johansson, A M, Perry, K, Nomikos, G G, Witkin, J M

“…Dopamine D(3) receptors have eluded definitive linkage to neurologic and psychiatric disorders since their cloning over 20 years ago. We report a new method…”
Get more information

AMPA receptor potentiators as novel antidepressants by Alt, A, Witkin, J M, Bleakman, D

“…Depression affects a large percentage of the general population and can produce devastating consequences to affected individuals, families and society…”
Get more information

M1 and m2 muscarinic receptor subtypes regulate antidepressant-like effects of the rapidly acting antidepressant scopolamine by Witkin, J M, Overshiner, C, Li, X, Catlow, J T, Wishart, G N, Schober, D A, Heinz, B A, Nikolayev, A, Tolstikov, V V, Anderson, W H, Higgs, R E, Kuo, M-S, Felder, C C

“…Scopolamine produces rapid and significant symptom improvement in patients with depression, and most notably in patients who do not respond to current…”
Get more information

The α2,3-selective potentiators of GABAA receptors, KRM-II-81 and MP-III-80, produce anxiolytic-like effects and block chemotherapy-induced hyperalgesia in mice without tolerance development by Biggerstaff, A., Kivell, B., Smith, J.L., Mian, Md Y., Golani, L.K., Rashid, F., Sharmin, D., Knutson, D.E., Cerne, R., Cook, J.M., Witkin, J.M.

“…Opiate analgesics are one of the treatment options for severe chronic pain, including late-stage cancer, chronic back pain and other disorders. The recent…”
Get full text

Perampanel, an antagonist of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, for the treatment of epilepsy: studies in human epileptic brain and nonepileptic brain and in rodent models by Zwart, R, Sher, E, Ping, X, Jin, X, Sims, Jr, J R, Chappell, A S, Gleason, S D, Hahn, P J, Gardinier, K, Gernert, D L, Hobbs, J, Smith, J L, Valli, S N, Witkin, J M

“…Perampanel [Fycompa, 2-(2-oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile hydrate 4:3; Eisai Inc., Woodcliff Lake, NJ] is an AMPA…”
Get more information

Behavioral effects and anticonvulsant efficacies of low-affinity, uncompetitive NMDA antagonists in mice by GETER-DOUGLASS, B, WITKIN, J. M

“…It has been hypothesized that low-affinity, uncompetitive N-methyl-d-aspartate (NMDA) antagonists may have therapeutic efficacy (e.g., in epilepsy, stroke,…”
Get full text

Selective histamine H3 receptor antagonists for treatment of cognitive deficiencies and other disorders of the central nervous system by Witkin, J M, Nelson, D L

“…Evidence exists to implicate the monoamine histamine in the control of arousal and cognitive functions. Antagonists of H(3) receptors are postsynaptic and…”
Get full text

The α2,3-selective potentiator of GABA A receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats by Witkin, J M, Cerne, R, Davis, P G, Freeman, K B, do Carmo, J M, Rowlett, J K, Methuku, K R, Okun, A, Gleason, S D, Li, X, Krambis, M J, Poe, M, Li, G, Schkeryantz, J M, Jahan, R, Yang, L, Guo, W, Golani, L K, Anderson, W H, Catlow, J T, Jones, T M, Porreca, F, Smith, J L, Knopp, K L, Cook, J M

“…Clinical evidence indicates that positive allosteric modulators (PAMs) of GABA receptors have analgesic benefit in addition to efficacy in anxiety disorders…”
Get full text

Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABA A receptors: Improved bioavailability enhances anticonvulsant efficacy by Witkin, J M, Smith, J L, Ping, X, Gleason, S D, Poe, M M, Li, G, Jin, X, Hobbs, J, Schkeryantz, J M, McDermott, J S, Alatorre, A I, Siemian, J N, Cramer, J W, Airey, D C, Methuku, K R, Tiruveedhula, V V N P B, Jones, T M, Crawford, J, Krambis, M J, Fisher, J L, Cook, J M, Cerne, R

“…HZ-166 has previously been characterized as an α2,3-selective GABA receptor modulator with anticonvulsant, anxiolytic, and anti-nociceptive properties but…”
Get full text

Behavioral effects of selective dopaminergic compounds in rats discriminating cocaine injections by Witkin, J M, Nichols, D E, Terry, P, Katz, J L

“…The involvement of dopamine receptor subtypes in the discriminative stimulus effects of cocaine was evaluated by the ability of a series of compounds selective…”
Get more information

Comparative Effects of LY3020371, a Potent and Selective Metabotropic Glutamate (mGlu) 2/3 Receptor Antagonist, and Ketamine, a Noncompetitive N -Methyl-d-Aspartate Receptor Antagonist in Rodents: Evidence Supporting the Use of mGlu2/3 Antagonists, for the Treatment of Depression by Witkin, J M, Mitchell, S N, Wafford, K A, Carter, G, Gilmour, G, Li, J, Eastwood, B J, Overshiner, C, Li, X, Rorick-Kehn, L, Rasmussen, K, Anderson, W H, Nikolayev, A, Tolstikov, V V, Kuo, M-S, Catlow, J T, Li, R, Smith, S C, Mitch, C H, Ornstein, P L, Swanson, S, Monn, J A

“…The ability of the -methyl-d-aspartate receptor antagonist ketamine to alleviate symptoms in patients suffering from treatment-resistant depression (TRD) is…”
Get more information

Further evaluation of the potential anxiolytic activity of imidazo[1,5-a][1,4]diazepin agents selective for α2/3-containing GABAA receptors by Witkin, J.M., Cerne, R., Wakulchik, M., S., J., Gleason, S.D., Jones, T.M., Li, G., Arnold, L.A., Li, J.-X., Schkeryantz, J.M., Methuku, K.R., Cook, J.M., Poe, M.M.

“…Positive allosteric modulators of GABAA receptors transduce a host of beneficial effects including anxiolytic actions. We have recently shown that…”
Get full text

Pharmacological and behavioral characterization of cocaine-kindled seizures in mice by MILLER, K. A, WITKIN, J. M, UNGARD, J. T, GASIOR, M

“…Convulsions associated with cocaine toxicity are a serious aspect of cocaine-related emergency room incidents. Seizures can result from a single high dose of…”
Get full text

An antidepressant-related pharmacological signature for positive allosteric modulators of α2/3-containing GABA A receptors by Methuku, K R, Li, X, Cerne, R, Gleason, S D, Schkeryantz, J M, Tiruveedhula, V V N P B, Golani, L K, Li, G, Poe, M M, Rahman, Md T, Cook, J M, Fisher, J L, Witkin, J M

“…Data from transgenic animals and novel pharmacological agents has realigned scientific scrutiny on the therapeutic potential of positive allosteric modulators…”
Get full text