Search Results - "Withers, Sarah B."

Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue by Saxton, Sophie N, Clark, Ben J, Withers, Sarah B, Eringa, Etto C, Heagerty, Anthony M

“…Obesity is increasingly prevalent and is associated with substantial cardiovascular risk. Adipose tissue distribution and morphology play a key role in…”
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Obesity-Related Perivascular Adipose Tissue Damage Is Reversed by Sustained Weight Loss in the Rat by Bussey, Charlotte E, Withers, Sarah B, Aldous, Robert G, Edwards, Gillian, Heagerty, Anthony M

“…Perivascular adipose tissue (PVAT) exerts an anticontractile effect in response to various vasoconstrictor agonists, and this is lost in obesity. A recent…”
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Local Inflammation and Hypoxia Abolish the Protective Anticontractile Properties of Perivascular Fat in Obese Patients by GREENSTEIN, Adam S, KHAVANDI, Kaivan, HEAGERTY, Anthony M, WITHERS, Sarah B, SONOYAMA, Kazuhiko, CLANCY, Olivia, JEZIORSKA, Maria, LAING, Ian, YATES, Allen P, PEMBERTON, Philip W, MALIK, Rayaz A

“…Inflammation in adipose tissue has been implicated in vascular dysfunction, but the local mechanisms by which this occurs are unknown. Small arteries with and…”
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Role of Sympathetic Nerves and Adipocyte Catecholamine Uptake in the Vasorelaxant Function of Perivascular Adipose Tissue by Saxton, Sophie N, Ryding, Katie E, Aldous, Robert G, Withers, Sarah B, Ohanian, Jacqueline, Heagerty, Anthony M

“…OBJECTIVE—Healthy perivascular adipose tissue (PVAT) exerts an anticontractile effect on resistance arteries which is vital in regulating arterial tone…”
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Perivascular Adipose Tissue Contributes to the Modulation of Vascular Tone in vivo by Saxton, Sophie N, Withers, Sarah B, Nyvad, Jakob, Mazur, Aleksandra, Matchkov, Vladimir, Heagerty, Anthony M, Aalkjær, Christian

“…Perivascular adipose tissue (PVAT) reduces vascular tone in isolated arteries in vitro, however there are no studies of PVAT effects on vascular tone in vivo…”
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Macrophage Activation Is Responsible for Loss of Anticontractile Function in Inflamed Perivascular Fat by Withers, Sarah B, Agabiti-Rosei, Claudia, Livingstone, Daniel M, Little, Matthew C, Aslam, Rehima, Malik, Rayaz A, Heagerty, Anthony M

“…OBJECTIVE—The aim of this study was to determine whether macrophages dispersed throughout perivascular fat are crucial to the loss of anticontractile function…”
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MiRNAs as Novel Adipokines: Obesity-Related Circulating MiRNAs Influence Chemosensitivity in Cancer Patients by Withers, Sarah B, Dewhurst, Toni, Hammond, Chloe, Topham, Caroline H

“…Adipose tissue is an endocrine organ, capable of regulating distant physiological processes in other tissues via the release of adipokines into the…”
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Emerging Roles of Sympathetic Nerves and Inflammation in Perivascular Adipose Tissue by Saxton, Sophie N., Withers, Sarah B., Heagerty, Anthony M.

“…Perivascular adipose tissue (PVAT) is no longer recognised as simply a structural support for the vasculature, and we now know that PVAT releases vasoactive…”
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Interleukin-33 rescues perivascular adipose tissue anticontractile function in obesity by Saxton, Sophie N, Whitley, Alice S, Potter, Ryan J, Withers, Sarah B, Grencis, Richard, Heagerty, Anthony M

“…Perivascular adipose tissue (PVAT) depots are metabolically active and play a major vasodilator role in healthy lean individuals. In obesity, they become…”
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Eosinophils are key regulators of perivascular adipose tissue and vascular functionality by Withers, Sarah B., Forman, Ruth, Meza-Perez, Selene, Sorobetea, Daniel, Sitnik, Kasia, Hopwood, Thomas, Lawrence, Catherine B., Agace, William W., Else, Kathryn J., Heagerty, Anthony M., Svensson-Frej, Marcus, Cruickshank, Sheena M.

“…Obesity impairs the relaxant capacity of adipose tissue surrounding the vasculature (PVAT) and has been implicated in resultant obesity-related hypertension…”
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Restoring Perivascular Adipose Tissue Function in Obesity Using Exercise by Saxton, Sophie N, Toms, Lauren K, Aldous, Robert G, Withers, Sarah B, Ohanian, Jacqueline, Heagerty, Anthony M

“…Purpose Perivascular adipose tissue (PVAT) exerts an anti-contractile effect which is vital in regulating vascular tone. This effect is mediated via…”
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β3‐Adrenoceptor stimulation of perivascular adipocytes leads to increased fat cell‐derived NO and vascular relaxation in small arteries by Bussey, Charlotte E, Withers, Sarah B, Saxton, Sophie N, Bodagh, Neil, Aldous, Robert G, Heagerty, Anthony M

“…Background and Purpose In response to noradrenaline, healthy perivascular adipose tissue (PVAT) exerts an anticontractile effect on adjacent small arterial…”
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Mechanisms of Adiponectin-Associated Perivascular Function in Vascular Disease by Withers, Sarah B, Bussey, Charlotte E, Saxton, Sophie N, Melrose, Heather M, Watkins, Amy E, Heagerty, Anthony M

“…The concept that fat cells could influence the circulation and indeed cardiac function has been in existence for ≥20 years and has gained a wide interest and…”
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Personalizing Hypertension Treatment? by Withers, Sarah B, Saxton, Sophie N, Heagerty, Anthony M

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cGMP-dependent protein kinase (PKG) mediates the anticontractile capacity of perivascular adipose tissue by Withers, Sarah B, Simpson, Laura, Fattah, Sharif, Werner, Matthias E, Heagerty, Anthony M

“…The aim of this study was to investigate the role of cGMP-dependent protein kinase (PKG) in mediating the anticontractile function of perivascular adipose…”
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Blockade of the renin-angiotensin system in small arteries and anticontractile function of perivascular adipose tissue by Rosei, Claudia Agabiti, Withers, Sarah B, Belcaid, Laila, De Ciuceis, Carolina, Rizzoni, Damiano, Heagerty, Anthony M

“…In patients with obesity, there is increased inflammation with attendant oxidative stress in perivascular adipose tissue. This has functional consequences with…”
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Anticontractile activity of perivascular fat in obese mice and the effect of long-term treatment with melatonin by Agabiti-Rosei, Claudia, De Ciuceis, Carolina, Rossini, Claudia, Porteri, Enzo, Rodella, Luigi F, Withers, Sarah B, Heagerty, Anthony M, Favero, Gaia, Agabiti-Rosei, Enrico, Rizzoni, Damiano, Rezzani, Rita

“…AIMS:It has been demonstrated previously that inflammation in perivascular adipose tissue (PVAT) may be implicated in vascular dysfunction. The aim of this…”
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β Integrins mediate FAK Y397 autophosphorylation of resistance arteries during eutrophic inward remodeling in hypertension by Heerkens, Egidius H J, Quinn, Lisa, Withers, Sarah B, Heagerty, Anthony M

“…Human essential hypertension is characterized by eutrophic inward remodeling of the resistance arteries with little evidence of hypertrophy. Upregulation of…”
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cGMP-dependent protein kinase (PKG) mediates the anticontractile capacity of perivascular adipose tissue by Withers, Sarah B., Simpson, Laura, Fattah, Sharif, Werner, Matthias E., Heagerty, Anthony M.

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C-Myb function in the vessel wall by Farrell, Kelly A, Withers, Sarah B, Holt, Cathy M

“…C-Myb is a DNA-binding transcription factor that functions in apoptosis, proliferation and differentiation. The role of c-Myb in vascular injury has been…”
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