Search Results - "Wither, Joan E"

Prevalence and metric of depression and anxiety in systemic lupus erythematosus: A systematic review and meta-analysis by Moustafa, Ahmed T., Moazzami, Mitra, Engel, Lisa, Bangert, Elvira, Hassanein, Mohamed, Marzouk, Sherief, Kravtsenyuk, Maryana, Fung, William, Eder, Lihi, Su, Jiandong, Wither, Joan E., Touma, Zahi

“…To systematically review and synthesize literature on 1) the overall prevalence of depression and anxiety in SLE patients in identified studies, and 2) the…”
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Identification of a neutrophil-related gene expression signature that is enriched in adult systemic lupus erythematosus patients with active nephritis: Clinical/pathologic associations and etiologic mechanisms by Wither, Joan E, Prokopec, Stephenie D, Noamani, Babak, Chang, Nan-Hua, Bonilla, Dennisse, Touma, Zahi, Avila-Casado, Carmen, Reich, Heather N, Scholey, James, Fortin, Paul R, Boutros, Paul C, Landolt-Marticorena, Carolina

“…Both a lack of biomarkers and relatively ineffective treatments constitute impediments to management of lupus nephritis (LN). Here we used gene expression…”
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Common variants in the NLRP3 region contribute to Crohn's disease susceptibility by Baba, Nobuyasu, Villani, Alexandra-Chloé, Belaiche, Jacques, Rutgeerts, Paul, Louis, Edouard, Fortin, Paul R, Silverberg, Mark S, Gaudet, Daniel, Bitton, Alain, Libioulle, Cécile, Langelier, Diane, Vermeire, Severine, Lemire, Mathieu, Fortin, Geneviève, Sarfati, Marika, Cohen, Albert, Collette, Catherine, Franchimont, Denis, Wither, Joan E, Hudson, Thomas J, Rioux, John D

“…We used a candidate gene approach to identify a set of SNPs, located in a predicted regulatory region on chromosome 1q44 downstream of NLRP3 (previously known…”
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Impaired B cell anergy is not sufficient to breach tolerance to nuclear antigen in Vκ8/3H9 lupus-prone mice by Manion, Kieran P., Baglaenko, Yuriy, Chang, Nan-Hua, Talaei, Nafiseh, Wither, Joan E.

“…Background Systemic lupus erythematosus (SLE) is a severe autoimmune disease in which immune tolerance defects drive production of pathogenic anti-nuclear…”
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Altered Balance of Pro-Inflammatory Immune Cells to T Regulatory Cells Differentiates Symptomatic From Asymptomatic Individuals With Anti-Nuclear Antibodies by Gupta, Rashi, Vanlieshout, Emma, Manion, Kieran, Bonilla, Dennisse, Kim, Michael, Muñoz-Grajales, Carolina, Nassar, Carol, Johnson, Sindhu R., Hiraki, Linda T., Ahmad, Zareen, Touma, Zahi, Bookman, Arthur, Wither, Joan E.

“…Systemic Autoimmune Rheumatic Diseases (SARDs) are characterized by the production of anti-nuclear antibodies (ANAs). ANAs are also seen in healthy individuals…”
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IL-10 Production Is Critical for Sustaining the Expansion of CD5+ B and NKT Cells and Restraining Autoantibody Production in Congenic Lupus-Prone Mice by Baglaenko, Yuriy, Manion, Kieran P, Chang, Nan-Hua, Gracey, Eric, Loh, Christina, Wither, Joan E

“…The development and progression of systemic lupus erythematosus is mediated by the complex interaction of genetic and environmental factors. To decipher the…”
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Multiple tolerance defects contribute to the breach of B cell tolerance in New Zealand Black chromosome 1 congenic mice by Chang, Nan-Hua, Manion, Kieran P, Loh, Christina, Pau, Evelyn, Baglaenko, Yuriy, Wither, Joan E

“…Lupus is characterized by a loss of B cell tolerance leading to autoantibody production. In this study, we explored the mechanisms underlying this loss of…”
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TLR tolerance reduces IFN-alpha production despite plasmacytoid dendritic cell expansion and anti-nuclear antibodies in NZB bicongenic mice by Pau, Evelyn, Cheung, Yui-Ho, Loh, Christina, Lajoie, Ginette, Wither, Joan E

“…Genetic loci on New Zealand Black (NZB) chromosomes 1 and 13 play a significant role in the development of lupus-like autoimmune disease. We have previously…”
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T cell and dendritic cell abnormalities synergize to expand pro-inflammatory T cell subsets leading to fatal autoimmunity in B6.NZBc1 lupus-prone mice by Talaei, Nafiseh, Cheung, Yui-Ho, Landolt-Marticorena, Carolina, Noamani, Babak, Li, Timothy, Wither, Joan E

“…We have previously shown that B6 congenic mice with a New Zealand Black chromosome 1 (c1) 96-100 cM interval produce anti-nuclear Abs and that at least two…”
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Abrogation of pathogenic IgG autoantibody production in CD40L gene-deleted lupus-prone New Zealand Black mice by Pau, Evelyn, Chang, Nan-Hua, Loh, Christina, Lajoie, Ginette, Wither, Joan E

“…Abstract New Zealand Black (NZB) mice spontaneously develop a lupus-like autoimmune disease. Since CD40–CD40L interactions are important for B cell…”
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A tyrosine sulfation-dependent HLA-I modification identifies memory B cells and plasma cells by Chan, Justin T H, Liu, Yanling, Khan, Srijit, St-Germain, Jonathan R, Zou, Chunxia, Leung, Leslie Y T, Yang, Judi, Shi, Mengyao, Grunebaum, Eyal, Campisi, Paolo, Propst, Evan J, Holler, Theresa, Bar-Or, Amit, Wither, Joan E, Cairo, Christopher W, Moran, Michael F, Palazzo, Alexander F, Cooper, Max D, Ehrhardt, Götz R A

“…Memory B cells and plasma cells are antigen-experienced cells tasked with the maintenance of humoral protection. Despite these prominent functions, definitive…”
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intrinsic B-cell defect supports autoimmunity in New Zealand black chromosome 13 congenic mice by Loh, Christina, Pau, Evelyn, Chang, Nan-Hua, Wither, Joan E

“…Introgression of a New Zealand Black (NZB) chromosome 13 interval onto a C57BL/6 (B6) background (B6.NZBc13) is sufficient to produce many hallmarks of lupus,…”
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Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus by Bentham, James, Morris, David L, Cunninghame Graham, Deborah S, Pinder, Christopher L, Tombleson, Philip, Behrens, Timothy W, Martín, Javier, Fairfax, Benjamin P, Knight, Julian C, Chen, Lingyan, Replogle, Joseph, Syvänen, Ann-Christine, Rönnblom, Lars, Graham, Robert R, Wither, Joan E, Rioux, John D, Alarcón-Riquelme, Marta E, Vyse, Timothy J

“…Timothy Vyse and colleagues report the results of a large-scale association study of systemic lupus erythematosus (SLE). They identify ten new susceptibility…”
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Bone Marrow-derived Human Hematopoietic Stem Cells Engraft NOD/SCID Mice and Traffic Appropriately to an Inflammatory Stimulus in the Joint by CHANG, Nan-Hua, INMAN, Robert D, DICK, John E, WITHER, Joan E

“…Objective. Studies of human inflammatory arthritis would be significantly aided by the development of better animal models. Our hypothesis is that it is…”
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Elevated Levels of Interferon‐α Act Directly on B Cells to Breach Multiple Tolerance Mechanisms Promoting Autoantibody Production by Ferri, Dario M., Nassar, Carol, Manion, Kieran P., Kim, Michael, Baglaenko, Yuriy, Muñoz‐Grajales, Carolina, Wither, Joan E.

“…Objective Elevated levels of serum interferon‐α (IFNα) and the disruption of B cell tolerance are central to systemic lupus erythematosus (SLE)…”
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Different Immunologic Profiles Are Associated With Distinct Clinical Phenotypes in Longitudinally Observed Patients With Systemic Lupus Erythematosus by Manion, Kieran, Muñoz‐Grajales, Carolina, Kim, Michael, Atenafu, Eshetu, Faheem, Zoha, Gladman, Dafna D., Urowitz, Murray, Touma, Zahi, Wither, Joan E.

“…Objective The aim of this study was to determine the immunologic profile associated with disease flares in patients with systemic lupus erythematosus (SLE) and…”
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Association of systemic lupus erythematosus (SLE) genetic susceptibility loci with lupus nephritis in childhood-onset and adult-onset SLE by Webber, Declan, Cao, Jingjing, Dominguez, Daniela, Gladman, Dafna D, Levy, Deborah M, Ng, Lawrence, Paterson, Andrew D, Touma, Zahi, Urowitz, Murray B, Wither, Joan E, Silverman, Earl D, Hiraki, Linda T

“…Abstract Objective LN is one of the most common and severe manifestations of SLE. Our aim was to test the association of SLE risk loci with LN risk in…”
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Immune mechanisms leading to abnormal B cell selection and activation in New Zealand Black mice by Roy, Valerie, Bonventi, Gabriel, Cai, Yongchun, MacLeod, Ralph, Wither, Joan E

“…Polyclonal B cell activation is a hallmark of the immune dysregulation in New Zealand Black (NZB) mice. We have previously shown that the splenic B cell…”
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Validity Evidence for the Use of Automated Neuropsychologic Assessment Metrics As a Screening Tool for Cognitive Impairment in Systemic Lupus Erythematosus by Tayer‐Shifman, Oshrat E., Green, Robin, Beaton, Dorcas E., Ruttan, Lesley, Wither, Joan E., Tartaglia, Maria Carmela, Kakvan, Mahta, Lombardi, Sabrina, Anderson, Nicole, Su, Jiandong, Bonilla, Dennisse, Zandy, Moe, Choi, May Y., Fritzler, Marvin J., Touma, Zahi

“…Objective Screening for cognitive impairment in systemic lupus erythematosus (SLE) conventionally relies on the American College of Rheumatology (ACR)…”
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Association of mycophenolate and azathioprine use with cognitive function in systemic lupus by Dobrowolski, Chrisanna, McGinley, John, Fazzari, Melissa, Su, Jiandong, Bingham, Kathleen S, Anderson, Nicole, Ruttan, Lesley, Beaton, Dorcas E, Wither, Joan E, Tartaglia, Maria Carmela, Kakvan, Mahta, Bonilla, Dennisse, Choi, May Y, Fritzler, Marvin J, Diaz Martinez, Juan Pablo, Katz, Patricia, Green, Robin, Putterman, Chaim, Touma, Zahi

“…Abstract Objectives Cognitive dysfunction (CD) is a common manifestation of SLE that can have detrimental consequences for those affected. To date, no…”
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