Search Results - "Witham, Miles D"

Research with older people in a world with COVID-19: identification of current and future priorities, challenges and opportunities by Richardson, Sarah J, Carroll, Camille B, Close, Jacqueline, Gordon, Adam L, O’Brien, John, Quinn, Terence J, Rochester, Lynn, Sayer, Avan A, Shenkin, Susan D, van der Velde, Nathalie, Woo, Jean, Witham, Miles D

“…Older people are disproportionately affected by the COVID-19 pandemic, which has had a profound impact on research as well as clinical service delivery. This…”
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Developing a roadmap to improve trial delivery for under-served groups: results from a UK multi-stakeholder process by Witham, Miles D, Anderson, Eleanor, Carroll, Camille, Dark, Paul M, Down, Kim, Hall, Alistair S, Knee, Joanna, Maier, Rebecca H, Mountain, Gail A, Nestor, Gary, Oliva, Laurie, Prowse, Sarah R, Tortice, Amanda, Wason, James, Rochester, Lynn

“…Participants in clinical research studies often do not reflect the populations for which healthcare interventions are needed or will be used. Enhancing…”
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Effect of vitamin D on blood pressure: a systematic review and meta-analysis by Witham, Miles D, Nadir, M Adnan, Struthers, Allan D

“…OBJECTIVESVitamin D insufficiency has been linked to hypertension and cardiovascular events in observational studies. It is unclear whether vitamin D…”
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Nutrition and Frailty: Opportunities for Prevention and Treatment by Ni Lochlainn, Mary, Cox, Natalie J, Wilson, Thomas, Hayhoe, Richard P G, Ramsay, Sheena E, Granic, Antoneta, Isanejad, Masoud, Roberts, Helen C, Wilson, Daisy, Welch, Carly, Hurst, Christopher, Atkins, Janice L, Mendonça, Nuno, Horner, Katy, Tuttiett, Esme R, Morgan, Yvie, Heslop, Phil, Williams, Elizabeth A, Steves, Claire J, Greig, Carolyn, Draper, John, Corish, Clare A, Welch, Ailsa, Witham, Miles D, Sayer, Avan A, Robinson, Sian

“…Frailty is a syndrome of growing importance given the global ageing population. While frailty is a multifactorial process, poor nutritional status is…”
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Developing the INCLUDE Ethnicity Framework-a tool to help trialists design trials that better reflect the communities they serve by Treweek, Shaun, Banister, Katie, Bower, Peter, Cotton, Seonaidh, Devane, Declan, Gardner, Heidi R, Isaacs, Talia, Nestor, Gary, Oshisanya, Adepeju, Parker, Adwoa, Rochester, Lynn, Soulsby, Irene, Williams, Hywel, Witham, Miles D

“…Ensuring that a trial is designed so that its participants reflect those who might benefit from the results, or be spared harms, is key to the potential…”
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Repurposing Drugs for Diabetes Mellitus as Potential Pharmacological Treatments for Sarcopenia – A Narrative Review by Witham, Miles D., Granic, Antoneta, Pearson, Ewan, Robinson, Sian M., Sayer, Avan A.

“…Sarcopenia, the age-related loss of muscle strength and mass or quality, is a common condition with major adverse consequences. Although the pathophysiology is…”
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Causes and correlates of 30 day and 180 day readmission following discharge from a Medicine for the Elderly Rehabilitation unit by Hughes, Lloyd D, Witham, Miles D

“…Recently hospitalized patients experience a period of generalized risk of adverse health events. This study examined reasons for, and predictors of,…”
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Sarcopenia and sarcopenic obesity among community-dwelling Peruvian adults: A cross-sectional study by Flores-Flores, Oscar, Zevallos-Morales, Alejandro, Pollard, Suzanne L, Checkley, William, Siddharthan, Trishul, Hurst, John R, Bernabé-Ortiz, Antonio, Runzer-Colmenares, Fernando M, Witham, Miles D, Parodi, Jose F

“…Sarcopenia and sarcopenic obesity (SO) have emerged as significant contributors to negative health outcomes in the past decade. We aimed to estimate the…”
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Experiences of hospital care for people with multiple long-term conditions: a scoping review of qualitative research by Bellass, Sue, Scharf, Thomas, Errington, Linda, Bowden Davies, Kelly, Robinson, Sian, Runacres, Adam, Ventre, Jodi, Witham, Miles D, Sayer, Avan A, Cooper, Rachel

“…Multiple long-term conditions-the co-existence of two or more chronic health conditions in an individual-present an increasing challenge to populations and…”
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Trial Forge Guidance 3: randomised trials and how to recruit and retain individuals from ethnic minority groups-practical guidance to support better practice by Dawson, Shoba, Banister, Katie, Biggs, Katie, Cotton, Seonaidh, Devane, Declan, Gardner, Heidi, Gillies, Katie, Gopalakrishnan, Gosala, Isaacs, Talia, Khunti, Kamlesh, Nichol, Alistair, Parker, Adwoa, Russell, Amy M, Shepherd, Victoria, Shiely, Frances, Shorter, Gillian, Starling, Bella, Williams, Hywel, Willis, Andrew, Witham, Miles D, Treweek, Shaun

“…Randomised trials, especially those intended to directly inform clinical practice and policy, should be designed to reflect all those who could benefit from…”
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Podiatry interventions to prevent falls in older people: a systematic review and meta-analysis by Wylie, Gavin, Torrens, Claire, Campbell, Pauline, Frost, Helen, Gordon, Adam Lee, Menz, Hylton B, Skelton, Dawn A, Sullivan, Frank, Witham, Miles D, Morris, Jacqui

“…Abstract Background foot problems are independent risk factors for falls in older people. Podiatrists diagnose and treat a wide range of problems affecting the…”
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Tackling immunosenescence to improve COVID-19 outcomes and vaccine response in older adults by Cox, Lynne S, Bellantuono, Ilaria, Lord, Janet M, Sapey, Elizabeth, Mannick, Joan B, Partridge, Linda, Gordon, Adam L, Steves, Claire J, Witham, Miles D

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Cardiovascular disease risk profile and management among people 40 years of age and above in Bo, Sierra Leone: A cross-sectional study by Odland, Maria Lisa, Gassama, Khadija, Bockarie, Tahir, Wurie, Haja, Ansumana, Rashid, Witham, Miles D, Oyebode, Oyinlola, Hirschhorn, Lisa R, Davies, Justine I

“…Introduction Access to care for cardiovascular disease risk factors (CVDRFs) in low- and middle-income countries is limited. We aimed to describe the need and…”
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The feasibility and acceptability of engaging older adults living with multiple long-term conditions, frailty, and a recent deterioration in health in research: Findings from the Lifestyle in Later Life - Older People's Medicine (LiLL-OPM) study by Hurst, Christopher, Dismore, Lorelle, Granic, Antoneta, Noble, Jane M, Hillman, Susan J, Witham, Miles D, Sayer, Avan A, Dodds, Richard M, Robinson, Sian M

“…Older adults living with multiple long-term conditions (MLTC, also known as multimorbidity) and frailty are more likely to experience a deterioration in their…”
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Identifying combinations of long-term conditions associated with sarcopenia: a cross-sectional decision tree analysis in the UK Biobank study by Hillman, Susan J, Dodds, Richard M, Granic, Antoneta, Witham, Miles D, Sayer, Avan A, Cooper, Rachel

“…ObjectivesThis study aims to determine whether machine learning can identify specific combinations of long-term conditions (LTC) associated with increased…”
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ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE trial by Rossios, Christos, Bashir, Tufail, Achison, Marcus, Adamson, Simon, Akpan, Asangaedem, Aspray, Terry, Avenell, Alison, Band, Margaret M, Burton, Louise A, Cvoro, Vera, Donnan, Peter T, Duncan, Gordon W, George, Jacob, Gordon, Adam L, Gregson, Celia L, Hapca, Adrian, Hume, Cheryl, Jackson, Thomas A, Kerr, Simon, Kilgour, Alixe, Masud, Tahir, McKenzie, Andrew, McKenzie, Emma, Patel, Harnish, Pilvinyte, Kristina, Roberts, Helen C, Sayer, Avan A, Smith, Karen T, Soiza, Roy L, Steves, Claire J, Struthers, Allan D, Tiwari, Divya, Whitney, Julie, Witham, Miles D, Kemp, Paul R

“…Background Angiotensin II (AII), has been suggested to promote muscle loss. Reducing AII synthesis, by inhibiting angiotensin converting enzyme (ACE) activity…”
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Activin type I receptor polymorphisms and body composition in older individuals with sarcopenia—Analyses from the LACE randomised controlled trial by Bashir, Tufail, Achison, Marcus, Adamson, Simon, Akpan, Asangaedem, Aspray, Terry, Avenell, Alison, Band, Margaret M, Burton, Louise A, Cvoro, Vera, Donnan, Peter T, Duncan, Gordon W, George, Jacob, Gordon, Adam L, Gregson, Celia L, Hapca, Adrian, Hume, Cheryl, Jackson, Thomas A, Kerr, Simon, Kilgour, Alixe, Masud, Tahir, McKenzie, Andrew, McKenzie, Emma, Patel, Harnish, Pilvinyte, Kristina, Roberts, Helen C, Rossios, Christos, Sayer, Avan A, Smith, Karen T, Soiza, Roy L, Steves, Claire J, Struthers, Allan D, Tiwari, Divya, Whitney, Julie, Witham, Miles D, Kemp, Paul R

“…Background Ageing is associated with changes in body composition including an overall reduction in muscle mass and a proportionate increase in fat mass…”
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Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial by Sumukadas, Deepa, Witham, Miles D, Struthers, Allan D, McMurdo, Marion E T

“…Physical function and exercise capacity decline with age and are a major source of disability in older people. Recent evidence suggests a potential role for…”
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Allopurinol and oxypurinol promote osteoblast differentiation and increase bone formation by Orriss, Isabel R., Arnett, Timothy R., George, Jacob, Witham, Miles D.

“…Allopurinol and its active metabolite, oxypurinol are widely used in the treatment of gout and hyperuricemia. They inhibit xanthine oxidase (XO) an enzyme in…”
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Effect of Vitamin D Supplementation on Markers of Vascular Function: A Systematic Review and Individual Participant Meta‐Analysis by Beveridge, Louise A., Khan, Faisel, Struthers, Allan D., Armitage, Jane, Barchetta, Ilaria, Bressendorff, Iain, Cavallo, Maria Gisella, Clarke, Robert, Dalan, Rinkoo, Dreyer, Gavin, Gepner, Adam D., Forouhi, Nita G., Harris, Ryan A., Hitman, Graham A., Larsen, Thomas, Khadgawat, Rajesh, Marckmann, Peter, Mose, Frank H., Pilz, Stefan, Scholze, Alexandra, Shargorodsky, Marina, Sokol, Seth I., Stricker, Hans, Zoccali, Carmine, Witham, Miles D.

“…Background Low 25‐hydroxyvitamin D levels are associated with an increased risk of cardiovascular events, but the effect of vitamin D supplementation on…”
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