Search Results - "Witczak, A"

Regulation of Skeletal Muscle Glucose Transport and Glucose Metabolism by Exercise Training by Evans, Parker L, McMillin, Shawna L, Weyrauch, Luke A, Witczak, Carol A

“…Aerobic exercise training and resistance exercise training are both well-known for their ability to improve human health; especially in individuals with type 2…”
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AMP-activated protein kinase in skeletal muscle: From structure and localization to its role as a master regulator of cellular metabolism by Witczak, C. A, Sharoff, C. G, Goodyear, L. J

“…The AMP-activated protein kinase (AMPK) is a metabolite sensing serine/threonine kinase that has been termed the master regulator of cellular energy metabolism…”
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Highly Efficient, Functional Engraftment of Skeletal Muscle Stem Cells in Dystrophic Muscles by Cerletti, Massimiliano, Jurga, Sara, Witczak, Carol A., Hirshman, Michael F., Shadrach, Jennifer L., Goodyear, Laurie J., Wagers, Amy J.

“…Satellite cells reside beneath the basal lamina of skeletal muscle fibers and include cells that act as precursors for muscle growth and repair. Although they…”
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Insulin Resistance Does Not Impair Mechanical Overload-Stimulated Glucose Uptake, but Does Alter the Metabolic Fate of Glucose in Mouse Muscle by Weyrauch, Luke A, McMillin, Shawna L, Witczak, Carol A

“…Skeletal muscle glucose uptake and glucose metabolism are impaired in insulin resistance. Mechanical overload stimulates glucose uptake into insulin-resistant…”
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AMP deamination is sufficient to replicate an atrophy-like metabolic phenotype in skeletal muscle by Miller, Spencer G., Hafen, Paul S., Law, Andrew S., Springer, Catherine B., Logsdon, David L., O'Connell, Thomas M., Witczak, Carol A., Brault, Jeffrey J.

“…Skeletal muscle atrophy, whether caused by chronic disease, acute critical illness, disuse or aging, is characterized by tissue-specific decrease in oxidative…”
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Increased AMP deaminase activity decreases ATP content and slows protein degradation in cultured skeletal muscle by Davis, Patrick R., Miller, Spencer G., Verhoeven, Nicolas A., Morgan, Joshua S., Tulis, David A., Witczak, Carol A., Brault, Jeffrey J.

“…Protein degradation is an energy-dependent process, requiring ATP at multiple steps. However, reports conflict as to the relationship between intracellular…”
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SMAD3 augments FoxO3-induced MuRF-1 promoter activity in a DNA-binding-dependent manner by Bollinger, Lance M, Witczak, Carol A, Houmard, Joseph A, Brault, Jeffrey J

“…Muscle-specific RING finger-1 (MuRF-1), a ubiquitin ligase and key regulator of proteasome-dependent protein degradation, is highly expressed during skeletal…”
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Distinct Signals Regulate AS160 Phosphorylation in Response to Insulin, AICAR, and Contraction in Mouse Skeletal Muscle by Kramer, Henning F, Witczak, Carol A, Fujii, Nobuharu, Jessen, Niels, Taylor, Eric B, Arnolds, David E, Sakamoto, Kei, Hirshman, Michael F, Goodyear, Laurie J

“…Distinct Signals Regulate AS160 Phosphorylation in Response to Insulin, AICAR, and Contraction in Mouse Skeletal Muscle Henning F. Kramer 1 , Carol A. Witczak…”
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Signaling mechanisms in skeletal muscle: Acute responses and chronic adaptations to exercise by Röckl, Katja S.C., Witczak, Carol A., Goodyear, Laurie J.

“…Physical activity elicits physiological responses in skeletal muscle that result in a number of health benefits, in particular in disease states, such as type…”
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Insulin Resistance Is Not Sustained Following Denervation in Glycolytic Skeletal Muscle by McMillin, Shawna L, Stanley, Erin C, Weyrauch, Luke A, Brault, Jeffrey J, Kahn, Barbara B, Witczak, Carol A

“…Denervation rapidly induces insulin resistance (i.e., impairments in insulin-stimulated glucose uptake and signaling proteins) in skeletal muscle…”
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Skeletal muscle myotubes in severe obesity exhibit altered ubiquitin‐proteasome and autophagic/lysosomal proteolytic flux by Bollinger, Lance M., Powell, Jonathan J. S., Houmard, Joseph A., Witczak, Carol A., Brault, Jeffrey J.

“…Objective Whole‐body protein metabolism is dysregulated with obesity. The goal of the study was to determine whether activity and expression of major protein…”
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CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle by Negoita, Florentina, Addinsall, Alex B., Hellberg, Kristina, Bringas, Conchita Fraguas, Hafen, Paul S., Sermersheim, Tyler J., Agerholm, Marianne, Lewis, Christopher T.A., Ahwazi, Danial, Ling, Naomi X.Y., Larsen, Jeppe K., Deshmukh, Atul S., Hossain, Mohammad A., Oakhill, Jonathan S., Ochala, Julien, Brault, Jeffrey J., Sankar, Uma, Drewry, David H., Scott, John W., Witczak, Carol A., Sakamoto, Kei

“…The AMP-activated protein kinase (AMPK) gets activated in response to energetic stress such as contractions and plays a vital role in regulating various…”
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Ca2+/Calmodulin-Dependent Protein Kinase Kinase-α Regulates Skeletal Muscle Glucose Uptake Independent of AMP-Activated Protein Kinase and Akt Activation by WITCZAK, Carol A, FUJII, Nobuharu, HIRSHMAN, Michael F, GOODYEAR, Laurie J

“…Ca 2+ /Calmodulin-Dependent Protein Kinase Kinase-α Regulates Skeletal Muscle Glucose Uptake Independent of AMP-Activated Protein Kinase and Akt Activation…”
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Muscle-Specific Ablation of Glucose Transporter 1 (GLUT1) Does Not Impair Basal or Overload-Stimulated Skeletal Muscle Glucose Uptake by McMillin, Shawna L, Evans, Parker L, Taylor, William M, Weyrauch, Luke A, Sermersheim, Tyler J, Welc, Steven S, Heitmeier, Monique R, Hresko, Richard C, Hruz, Paul W, Koumanov, Francoise, Holman, Geoffrey D, Abel, E Dale, Witczak, Carol A

“…Glucose transporter 1 (GLUT1) is believed to solely mediate basal (insulin-independent) glucose uptake in skeletal muscle; yet recent work has demonstrated…”
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Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle by Treebak, Jonas T, Taylor, Eric B, Witczak, Carol A, An, Ding, Toyoda, Taro, Koh, Ho-Jin, Xie, Jianxin, Feener, Edward P, Wojtaszewski, Jørgen F P, Hirshman, Michael F, Goodyear, Laurie J

“…TBC1D4 (also known as AS160) regulates glucose transporter 4 (GLUT4) translocation and glucose uptake in adipocytes and skeletal muscle. Its mode of action…”
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Short-term, high-fat diet accelerates disuse atrophy and protein degradation in a muscle-specific manner in mice by Roseno, Steven L, Davis, Patrick R, Bollinger, Lance M, Powell, Jonathan J S, Witczak, Carol A, Brault, Jeffrey J

“…A short-term high-fat diet impairs mitochondrial function and the ability of skeletal muscle to respond to growth stimuli, but it is unknown whether such a…”
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Estrogen receptor-α in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation by Iñigo, Melissa R., Amorese, Adam J., Tarpey, Michael D., Balestrieri, Nicholas P., Jones, Keith G., Patteson, Daniel J., Jackson, Kathryn C., Torres, Maria.J., Lin, Chien-Te, Smith, Cody D., Heden, Timothy D., McMillin, Shawna L., Weyrauch, Luke A., Stanley, Erin C., Schmidt, Cameron A., Kilburg-Basnyat, Brita B., Reece, Sky W., Psaltis, Christine E., Leinwand, Leslie A., Funai, Katsuhiko, McClung, Joseph M., Gowdy, Kymberly M., Witczak, Carol A., Lowe, Dawn A., Neufer, P. Darrell, Spangenburg, Espen E.

“…Estrogen receptor-α (ERα) is a nuclear receptor family member thought to substantially contribute to the metabolic regulation of skeletal muscle. However,…”
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AS160 Regulates Insulin- and Contraction-stimulated Glucose Uptake in Mouse Skeletal Muscle by Kramer, Henning F., Witczak, Carol A., Taylor, Eric B., Fujii, Nobuharu, Hirshman, Michael F., Goodyear, Laurie J.

“…Insulin and contraction are potent stimulators of GLUT4 translocation and increase skeletal muscle glucose uptake. We recently identified the Rab…”
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Calmodulin-Binding Domain of AS160 Regulates Contraction- but Not Insulin-Stimulated Glucose Uptake in Skeletal Muscle by Kramer, Henning F, Taylor, Eric B, Witczak, Carol A, Fujii, Nobuharu, Hirshman, Michael F, Goodyear, Laurie J

“…Calmodulin-Binding Domain of AS160 Regulates Contraction- but Not Insulin-Stimulated Glucose Uptake in Skeletal Muscle Henning F. Kramer 1 , Eric B. Taylor 1 ,…”
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Transplantation of mononuclear cells from human umbilical cord blood promotes functional recovery after traumatic spinal cord injury in Wistar rats by Rodrigues, L P, Iglesias, D, Nicola, F C, Steffens, D, Valentim, L, Witczak, A, Zanatta, G, Achaval, M, Pranke, P, Netto, C A

“…Cell transplantation is a promising experimental treatment for spinal cord injury. The aim of the present study was to evaluate the efficacy of mononuclear…”
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