Search Results - "Witchell, Donna"

Antisense oligonucleotide reduction of apoB-ameliorated atherosclerosis in LDL receptor-deficient mice[S] by Mullick, Adam E., Fu, Wuxia, Graham, Mark J., Lee, Richard G., Witchell, Donna, Bell, Thomas A., Whipple, Charles P., Crooke, Rosanne M.

“…Chronic elevations of plasma apolipoprotein B (apoB) are strongly associated with cardiovascular disease. We have previously demonstrated that inhibition of…”
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Specific Inhibition of PTEN Expression Reverses Hyperglycemia in Diabetic Mice by BUTLER, Madeline, MCKAY, Robert A, POPOFF, Ian J, GAARDE, William A, WITCHELL, Donna, MURRAY, Susan F, DEAN, Nicholas M, BHANOT, Sanjay, MONIA, Brett P

“…Specific Inhibition of PTEN Expression Reverses Hyperglycemia in Diabetic Mice Madeline Butler , Robert A. McKay , Ian J. Popoff , William A. Gaarde , Donna…”
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Antisense oligonucleotide blockade of tumor necrosis factor-alpha in two murine models of colitis by Myers, Kathleen J, Murthy, Sreekant, Flanigan, Anne, Witchell, Donna R, Butler, Madeline, Murray, Susan, Siwkowski, Andrew, Goodfellow, Deborah, Madsen, Karen, Baker, Brenda

“…Tumor necrosis factor-alpha (TNF-alpha) is a key cytokine involved in the pathogenesis of inflammatory bowel disease. We have developed a second-generation…”
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Antisense oligonucleotide blockade of alpha 4 integrin prevents and reverses clinical symptoms in murine experimental autoimmune encephalomyelitis by Myers, Kathleen J., Witchell, Donna R., Graham, Mark J., Koo, Seongjoon, Butler, Madeline, Condon, Thomas P.

“…We investigated the use of an antisense oligonucleotide (ASO) specific for mRNA of the alpha chain (CD49d) of mouse VLA-4 to down-regulate VLA-4 expression and…”
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Phosphorothioate oligodeoxynucleotides distribute similarly in class A scavenger receptor knockout and wild-type mice by Butler, M, Crooke, R M, Graham, M J, Lemonidis, K M, Lougheed, M, Murray, S F, Witchell, D, Steinbrecher, U, Bennett, C F

“…It has been suggested that binding of phosphorothioate oligodeoxynucleotides (P=S ODNs) to macrophage scavenger receptors (SR-AI/II) is the primary mechanism…”
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Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals by Seth, Punit P, Siwkowski, Andrew, Allerson, Charles R, Vasquez, Guillermo, Lee, Sam, Prakash, Thazha P, Wancewicz, Edward V, Witchell, Donna, Swayze, Eric E

“…The potency of second generation antisense oligonucleotides (ASOs) in animals was increased 3- to 5 -fold (ED50 ≈ 2−5 mg/kg) without producing hepatotoxicity,…”
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Selective Abrogation of STAT5 Expression Impairs the Proliferation of Acute Myeloid Leukemia Cells with Various Cytogenetic Alterations by Kim, Youngsoo, Zhou, Tianyuan, Guo, Shuling, Siwkowski, Andy, Witchell, Donna, Pandey, Sanjay, Monia, Brett P.

“…STAT5 is a key common downstream mediator of multiple signaling pathways which are often dysregulated in various hematologic malignancies, including acute…”
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A Sense Oligonucleotide Specifically Reverses the Prothrombin Depletion and Anticoagulation Caused by ISIS 401025, an Antisense Oligonucleotide Targeting Prothrombin RNA in Mice by Zhao, Chenguang, Monia, Brett P., Siwkowski, Andy, Freier, Sue, Witchell, Donna, Zhang, Hong

“…The ability to safely and effectively neutralize anticoagulant activity is of particular importance in the case of long acting drugs. While antisense…”
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Antisense Strategies to Specifically Deplete Levels of Factors II, VII and IX in Mice To Assess Their Potential as Targets for Anticoagulation by Zhang, Hong, Zhao, Chenguang, Crosby, Jeff, Siwkowski, Andy, Freier, Sue, Witchell, Donna, Monia, Brett P.

“…Numerous potential intervention points exist within coagulation pathways for development of novel anticoagulant agents. To help determine the most suitable…”
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Inhibition of TNFα secretion with an antisense oligonucleotide is effective in preventing colitis in the IL-10−/− mouse by Madsen, Karen L., Myers, Kathleen, Baker, Brenda, Witchell, Donna, Yachimec, Christine, Cornish, Anthony

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Specific Inhibition of PTEN Expression with an Antisense Oligonucleotide Normalizes Plasma Glucose in db/db Mice by MCKAY, ROBERT A, BUTLER, MADELINE, POPOFF, IAN J, GAARDE, WILLIAM, WITCHELL, DONNA, DEAN, NICHOLAS M, MONIA, BRETT P

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Evaluation of C-5 propynyl pyrimidine-containing oligonucleotides in vitro and in vivo by Shen, Lijiang, Siwkowski, Andrew, Wancewicz, Edward V, Lesnik, Elena, Butler, Madeline, Witchell, Donna, Vasquez, Guillermo, Ross, Bruce, Acevedo, Oscar, Inamati, Gopal, Sasmor, Henri, Manoharan, Muthiah, Monia, Brett P

“…Inclusion of C-5 propynyl pyrimidines in phosphorothioate antisense oligonucleotides (ASOs) has been shown to significantly increase their potency for…”
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