Search Results - "Wistuba, J"

Complete spermatogenesis in intratesticular testis tissue xenotransplants from immature non-human primate by Ntemou, E, Kadam, P, Van Saen, D, Wistuba, J, Mitchell, R T, Schlatt, S, Goossens, E

“…Abstract STUDY QUESTION Can full spermatogenesis be achieved after xenotransplantation of prepubertal primate testis tissue to the mouse, in testis or…”
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Challenging human somatic testicular cell reassembly by protein kinase inhibition –setting up a functional in vitro test system by Mincheva, M., Wistuba, J., Brenker, C., Schlatt, S.

“…Signalling pathways and cellular interactions defining initial processes of testis morphogenesis, i.e. cord formation, are poorly understood. In vitro…”
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A combined approach facilitates the reliable detection of human spermatogonia in vitro by Kossack, N., Terwort, N., Wistuba, J., Ehmcke, J., Schlatt, S., Schöler, H., Kliesch, S., Gromoll, J.

“…STUDY QUESTION Does a combined approach allow for the unequivocal detection of human germ cells and particularly of spermatogonia in vitro? SUMMARY ANSWER…”
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Testicular function in males with infantile nephropathic cystinosis by Rohayem, J, Haffner, D, Cremers, J F, Huss, S, Wistuba, J, Weitzel, D, Kliesch, S, Hohenfellner, K

“…Do males with the rare lysosomal storage disease infantile nephropathic cystinosis (INC) have a chance of biological fatherhood? Cryostorage of semen could be…”
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Topographic protein profiling of the age-related proteome in the retinal pigment epithelium of Callithrix jacchus with respect to macular degeneration by König, S., Hadrian, K., Schlatt, S., Wistuba, J., Thanos, S., Böhm, M.R.R.

“…In the retinal pigment epithelium (RPE) several factors within the macular compared to peripheral regions cause differences in physiological aging. The…”
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The initial maturation status of marmoset testicular tissues has an impact on germ cell maintenance and somatic cell response in tissue fragment culture by Heckmann, L, Langenstroth-Röwer, D, Wistuba, J, Portela, J M D, van Pelt, A M M, Redmann, K, Stukenborg, J B, Schlatt, S, Neuhaus, N

“…Abstract Successful in vitro spermatogenesis was reported using immature mouse testicular tissues in a fragment culture approach, raising hopes that this…”
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Age and markers of Leydig cell function, but not of Sertoli cell function predict the success of sperm retrieval in adolescents and adults with Klinefelter's syndrome by Rohayem, J., Fricke, R., Czeloth, K., Mallidis, C., Wistuba, J., Krallmann, C., Zitzmann, M., Kliesch, S.

“…Summary Microsurgical testicular sperm extraction (mTESE), combined with intracytoplasmic sperm injection (ICSI) represents a chance for azoospermic men with…”
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A diagnostic germ cell score for immature testicular tissue at risk of germ cell loss by Heckmann, L, Langenstroth-Röwer, D, Pock, T, Wistuba, J, Stukenborg, J -B, Zitzmann, M, Kliesch, S, Schlatt, S, Neuhaus, N

“…Abstract STUDY QUESTION Can a systematic scoring procedure provide crucial information on the status of highly heterogeneous immature human testicular tissues…”
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Irradiation affects germ and somatic cells in prepubertal monkey testis xenografts by Tröndle, I, Westernströer, B, Wistuba, J, Terwort, N, Schlatt, S, Neuhaus, N

“…Does irradiation evoke adverse effects in germ and somatic cells in testis xenografts from prepubertal monkeys? In addition to the expected depletion of germ…”
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Reassembly of adult human testicular cells: can testis cord-like structures be created in vitro? by Mincheva, M, Sandhowe-Klaverkamp, R, Wistuba, J, Redmann, K, Stukenborg, J -B, Kliesch, S, Schlatt, S

“…Abstract STUDY QUESTION Can enzymatically dispersed testicular cells from adult men reassemble into seminiferous cord-like structures in vitro? SUMMARY ANSWER…”
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Reassembly of adult human testicular cells: can testis cord-like structures be createdin vitro? by Mincheva, M, Sandhowe-Klaverkamp, R, Wistuba, J, Redmann, K, Stukenborg, J-B, Kliesc, S, Schlatt, S

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Ageing in men with normal spermatogenesis alters spermatogonial dynamics and nuclear morphology in Sertoli cells by Pohl, E., Höffken, V., Schlatt, S., Kliesch, S., Gromoll, J., Wistuba, J.

“…Background Ageing in men is believed to be associated with fertility decline and elevated risk of congenital disorders for the offspring. The previous studies…”
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A novel xeno-organoid approach: exploring the crosstalk between human iPSC-derived PGC-like and rat testicular cells by Mall, E M, Rotte, N, Yoon, J, Sandhowe-Klaverkamp, R, Röpke, A, Wistuba, J, Hübner, K, Schöler, H R, Schlatt, S

“…Abstract Specification of germ cell-like cells from induced pluripotent stem cells has become a clinically relevant tool for research. Research on initial…”
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In situ visualization of damaged DNA in human sperm by Raman microspectroscopy by Mallidis, C., Wistuba, J., Bleisteiner, B., Damm, O.S., Groß, P., Wübbeling, F., Fallnich, C., Burger, M., Schlatt, S.

“…BACKGROUND Beyond determining the percentage of damaged sperm, current methods of DNA assessment are of limited clinical utility as they render the sample…”
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The Klinefelter syndrome: current management and research challenges by Nieschlag, E., Ferlin, A., Gravholt, C. H., Gromoll, J., Köhler, B., Lejeune, H., Rogol, A. D., Wistuba, J.

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Analysis of copy number variation in men with non‐obstructive azoospermia by Wyrwoll, M. J., Wabschke, R., Röpke, A., Wöste, M., Ruckert, C., Perrey, S., Rotte, N., Hardy, J., Astica, L., Lupiáñez, D. G., Wistuba, J., Westernströer, B., Schlatt, S., Berman, A. J., Müller, A. M., Kliesch, S., Yatsenko, A. N., Tüttelmann, F., Friedrich, C.

“…Background Recent findings demonstrate that single nucleotide variants can cause non‐obstructive azoospermia (NOA). In contrast, copy number variants (CNVs)…”
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Raman microspectroscopy: a non-destructive approach for the analysis of DNA in living sperm by Sanchez, V, Wistuba, J, Kliesch, S, Schlatt, S, Mallidis, C

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In-depth characterization of human testicular tissue from patients suffering from gender identity disorder (GID) undergoing sex-reassignment surgery (SRS) by Schneider, F.J, Kossack, N, Wistuba, J, Schlatt, S, Kliesch, S

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Germ cell dynamics in the testis of the postnatal common marmoset monkey (Callithrix jacchus) by Albert, S, Ehmcke, J, Wistuba, J, Eildermann, K, Behr, R, Schlatt, S, Gromoll, J

“…The seminiferous epithelium in the nonhuman primate Callithrix jacchus is similarly organized to man. This monkey has therefore been used as a preclinical…”
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An alternative interpretation of cellular ‘selfish spermatogonial selection’‐ clusters in the human testis indicates the need for 3‐D‐analyses by Pohl, E., Gromoll, J., Kliesch, S., Wistuba, J.

“…Summary The ‘selfish spermatogonial selection’‐ model was proposed to explain the paternal age effect (PAE) of some congenital disorders associated with point…”
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