Search Results - "Wistow, Graeme J."

Functions of crystallins in and out of lens: Roles in elongated and post-mitotic cells by Slingsby, Christine, Wistow, Graeme J.

“…The vertebrate lens evolved to collect light and focus it onto the retina. In development, the lens grows through massive elongation of epithelial cells…”
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Evolution of crystallins for a role in the vertebrate eye lens by Slingsby, Christine, Wistow, Graeme J., Clark, Alice R.

“…The camera eye lens of vertebrates is a classic example of the re‐engineering of existing protein components to fashion a new device. The bulk of the lens is…”
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The Lacrimal Gland Transcriptome Is an Unusually Rich Source of Rare and Poorly Characterized Gene Transcripts by Ozyildirim, Aylin M, Wistow, Graeme J, Gao, James, Wang, Jiahu, Dickinson, Douglas P, Frierson, Henry F., Jr, Laurie, Gordon W

“…To sequence and comprehensively analyze human and mouse lacrimal gland transcriptomes as part of the NEIBank project. cDNA libraries generated from normal…”
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Editorial for special issue: Crystallins of the eye by Wistow, Graeme J., Slingsby, Christine

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Gene duplication and separation of functions in αB‐crystallin from zebrafish (Danio rerio) by Smith, Amber A., Wyatt, Keith, Vacha, Jennifer, Vihtelic, Thomas S., Samuel Zigler, J., Wistow, Graeme J., Posner, Mason

“…We previously reported that zebrafish αB‐crystallin is not constitutively expressed in nervous or muscular tissue and has reduced chaperone‐like activity…”
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pBendBlue: modification of the pBend system for color selectability by Sperbeck, S J, Wistow, G J

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Lens Crystallins: The Evolution and Expression of Proteins for a Highly Specialized Tissue by Wistow, G J, Piatigorsky, J

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Enzyme Activity of Macrophage Migration Inhibitory Factor toward Oxidized Catecholamines by Matsunaga, Jun, Sinha, Debasish, Pannell, Lew, Santis, Chie, Solano, Francisco, Wistow, Graeme J., Hearing, Vincent J.

“…Macrophage migration inhibitory factor (MIF) is a relatively small, 12.5-kDa protein that is structurally related to some isomerases and for which multiple…”
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Biomedical applications of synchrotron radiation circular dichroism spectroscopy: identification of mutant proteins associated with disease and development of a reference database for fold motifs by Wallace, B A, Wien, Frank, Miles, Andrew J, Lees, Jonathan G, Hoffmann, Soren Vronning, Evans, Paul, Wistow, Graeme J, Slingsby, Christine

“…Synchrotron radiation circular dichroism (SRCD) spectroscopy is an emerging technique in structural biology with particular value for accurate secondary…”
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The enzyme lactate dehydrogenase as a structural protein in avian and crocodilian lenses by Wistow, Graeme J, Mulders, John W. M, de Jong, Wilfried W

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A Macrophage Migration Inhibitory Factor is Expressed in the Differentiating Cells of the Eye Lens by Wistow, Graeme J., Shaughnessy, Michael P., Lee, Douglas C., Hodin, Jason, Zelenka, Peggy S.

“…A discrete 10-kDa polypeptide (10K) is expressed from early stages in the embryonic chicken lens. Since this has potential as a marker for lens cell…”
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Enzyme/crystallins: gene sharing as an evolutionary strategy by Piatigorsky, J, Wistow, G J

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DNA sequence motifs are associated with aberrant homologous recombination in the mouse macrophage migration inhibitory factor (Mif) locus by Kobayashi, Shigetoshi, Yoshida, Kunihiro, Ohshima, Toshio, Esumi, Noriko, Paralkar, Vishwas M, Wistow, Graeme J, Kulkarni, Ashok B

“…Homologous recombination is a precise genetic event that can introduce specific alteration in the genome. A planned targeted disruption by homologous…”
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Biophysical Properties of γC-Crystallin in Human and Mouse Eye Lens: The Role of Molecular Dipoles by Purkiss, Andrew G., Bateman, Orval A., Wyatt, Keith, Wilmarth, Phillip A., David, Larry L., Wistow, Graeme J., Slingsby, Christine

“…The eye lens is packed with soluble crystallin proteins, providing a lifetime of transparency and light refraction. γ-Crystallins are major components of the…”
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Expression pattern of macrophage migration inhibitory factor during embryogenesis by Kobayashi, Shigetoshi, Satomura, Kazuhito, Levsky, Jeffrey M., Sreenath, Taduru, Wistow, Graeme J., Semba, Ichiro, Shum, Lillian, Slavkin, Harold C., Kulkarni, Ashok B.

“…Although macrophage migration inhibitory factor (MIF) was originally identified as a lymphokine that inhibits the migration of macrophages, its ubiquitous…”
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Biophysical properties of gammaC-crystallin in human and mouse eye lens: the role of molecular dipoles by Purkiss, Andrew G, Bateman, Orval A, Wyatt, Keith, Wilmarth, Phillip A, David, Larry L, Wistow, Graeme J, Slingsby, Christine

“…The eye lens is packed with soluble crystallin proteins, providing a lifetime of transparency and light refraction. gamma-Crystallins are major components of…”
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Gene duplication and separation of functions in [alpha]B-crystallin from zebrafish (Danio rerio) by Smith, Amber A, Wyatt, Keith, Vacha, Jennifer, Vihtelic, Thomas S, ZiglerJr, J Samuel, Wistow, Graeme J, Posner, Mason

“…We previously reported that zebrafish alpha B-crystallin is not constitutively expressed in nervous or muscular tissue and has reduced chaperone-like activity…”
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Gene duplication and separation of functions in alphaB-crystallin from zebrafish (Danio rerio) by Smith, Amber A, Wyatt, Keith, Vacha, Jennifer, Vihtelic, Thomas S, Zigler, Jr, J S, Wistow, Graeme J, Posner, Mason

“…We previously reported that zebrafish alphaB-crystallin is not constitutively expressed in nervous or muscular tissue and has reduced chaperone-like activity…”
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Tandem sequence repeats in transmembrane channel proteins by Wistow, G J, Pisano, M M, Chepelinsky, A B

“…The flow of ions and small molecules out of and between cells is mediated by various classes of transmembrane proteins. One group of putative channel proteins,…”
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The enzyme lactate dehydrogenase as a structural protein in avian and crocodilian lenses by Wistow, G J, Mulders, J W, de Jong, W W

“…The major components of mammalian lenses are tissue-specific, soluble proteins, the alpha-, beta- and gamma-crystallins. The lenses of other vertebrate classes…”
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