Search Results - "Wisse, Patrick"

Lysosomal glycosphingolipid catabolism by acid ceramidase: formation of glycosphingoid bases during deficiency of glycosidases by Ferraz, Maria J., Marques, André R. A., Appelman, Monique D., Verhoek, Marri, Strijland, Anneke, Mirzaian, Mina, Scheij, Saskia, Ouairy, Cécile M., Lahav, Daniel, Wisse, Patrick, Overkleeft, Herman S., Boot, Rolf G., Aerts, Johannes M.

“…Glycosphingoid bases are elevated in inherited lysosomal storage disorders with deficient activity of glycosphingolipid catabolizing glycosidases. We…”
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Gaucher disease and Fabry disease: New markers and insights in pathophysiology for two distinct glycosphingolipidoses by Ferraz, Maria J., Kallemeijn, Wouter W., Mirzaian, Mina, Herrera Moro, Daniela, Marques, Andre, Wisse, Patrick, Boot, Rolf G., Willems, Lianne I., Overkleeft, H.S., Aerts, J.M.

“…Gaucher disease (GD) and Fabry disease (FD) are two relatively common inherited glycosphingolipidoses caused by deficiencies in the lysosomal glycosidases…”
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Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases[S] by Marques, AndréR.A., Mirzaian, Mina, Akiyama, Hisako, Wisse, Patrick, Ferraz, Maria J., Gaspar, Paulo, Ghauharali-van der Vlugt, Karen, Meijer, Rianne, Giraldo, Pilar, Alfonso, Pilar, Irún, Pilar, Dahl, Maria, Karlsson, Stefan, Pavlova, Elena V., Cox, Timothy M., Scheij, Saskia, Verhoek, Marri, Ottenhoff, Roelof, van Roomen, CindyP.A.A., Pannu, Navraj S., van Eijk, Marco, Dekker, Nick, Boot, Rolf G., Overkleeft, Herman S., Blommaart, Edward, Hirabayashi, Yoshio, Aerts, Johannes M.

“…The membrane lipid glucosylceramide (GlcCer) is continuously formed and degraded. Cells express two GlcCer-degrading β-glucosidases, glucocerebrosidase (GBA)…”
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Mass spectrometric quantification of glucosylsphingosine in plasma and urine of type 1 Gaucher patients using an isotope standard by Mirzaian, Mina, Wisse, Patrick, Ferraz, Maria J., Gold, Henrik, Donker-Koopman, Wilma E., Verhoek, Marri, Overkleeft, Herman S., Boot, Rolf G., Kramer, Gertjan, Dekker, Nick, Aerts, Johannes M.F.G.

“…Deficiency of glucocerebrosidase (GBA) leads to Gaucher disease (GD), an inherited disorder characterised by storage of glucosylceramide (GlcCer) in lysosomes…”
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Near-infrared labeled, ovalbumin loaded polymeric nanoparticles based on a hydrophilic polyester as model vaccine: In vivo tracking and evaluation of antigen-specific CD8+ T cell immune response by Rahimian, Sima, Kleinovink, Jan Willem, Fransen, Marieke F, Mezzanotte, Laura, Gold, Henrik, Wisse, Patrick, Overkleeft, Hermen, Amidi, Maryam, Jiskoot, Wim, Löwik, Clemens W, Ossendorp, Ferry, Hennink, Wim E

“…Abstract Particulate antigen delivery systems aimed at the induction of antigen-specific T cells form a promising approach in immunotherapy to replace…”
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Biochemical response to substrate reduction therapy versus enzyme replacement therapy in Gaucher disease type 1 patients by Smid, Bouwien E, Ferraz, Maria J, Verhoek, Marri, Mirzaian, Mina, Wisse, Patrick, Overkleeft, Herman S, Hollak, Carla E, Aerts, Johannes M

“…We retrospectively compared biochemical responses in type 1 Gaucher disease patients to treatment with glycosphingolipid synthesis inhibitors miglustat and…”
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Lyso-glycosphingolipid abnormalities in different murine models of lysosomal storage disorders by Ferraz, Maria J., Marques, André R.A., Gaspar, Paulo, Mirzaian, Mina, van Roomen, Cindy, Ottenhoff, Roelof, Alfonso, Pilar, Irún, Pilar, Giraldo, Pilar, Wisse, Patrick, Sá Miranda, Clara, Overkleeft, Herman S., Aerts, Johannes M.

“…In lysosomal glycosphingolipid storage disorders, marked elevations in corresponding glycosphingoid bases (lyso-glycosphingolipids) have been reported, such as…”
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Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with (13)C-encoded natural S1P as internal standard by Mirzaian, Mina, Wisse, Patrick, Ferraz, Maria J, Marques, André R A, Gabriel, Tanit L, van Roomen, Cindy P A A, Ottenhoff, Roelof, van Eijk, Marco, Codée, Jeroen D C, van der Marel, Gijsbert A, Overkleeft, Herman S, Aerts, Johannes M

“…We developed a mass spectrometric procedure to quantify sphingosine-1-phosphate (S1P) in biological materials. The use of newly synthesized (13)C5 C18-S1P and…”
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Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with 13C-encoded natural S1P as internal standard by Mirzaian, Mina, Wisse, Patrick, Ferraz, Maria J., Marques, André R.A., Gabriel, Tanit L., van Roomen, Cindy P.A.A., Ottenhoff, Roelof, van Eijk, Marco, Codée, Jeroen D.C., van der Marel, Gijsbert A., Overkleeft, Herman S., Aerts, Johannes M.

“…We developed a mass spectrometric procedure to quantify sphingosine-1-phosphate (S1P) in biological materials. The use of newly synthesized 13C5 C18-S1P and…”
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Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with 13 C-encoded natural S1P as internal standard by Mirzaian, Mina, Wisse, Patrick, Ferraz, Maria J., Marques, André R.A., Gabriel, Tanit L., van Roomen, Cindy P.A.A., Ottenhoff, Roelof, van Eijk, Marco, Codée, Jeroen D.C., van der Marel, Gijsbert A., Overkleeft, Herman S., Aerts, Johannes M.

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Synthesis of a Panel of Carbon-13-Labelled (Glyco)Sphingolipids by Wisse, Patrick, Gold, Henrik, Mirzaian, Mina, Ferraz, Maria J., Lutteke, Ginger, van den Berg, Richard J. B. H. N., van den Elst, Hans, Lugtenburg, Johan, van der Marel, Gijsbert A., Aerts, Johannes M. F. G., Codée, Jeroen D. C., Overkleeft, Herman S.

“…The synthesis of a focussed library of sphingolipids differing in the number and position of 13C labels is described. The synthesised sphingolipids differ in…”
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Synthesis of 6‑Hydroxysphingosine and α‑Hydroxy Ceramide Using a Cross-Metathesis Strategy by Wisse, Patrick, de Geus, Mark A. R, Cross, Gen, van den Nieuwendijk, Adrianus M. C. H, van Rooden, Eva J, van den Berg, Richard J. B. H. N, Aerts, Johannes M. F. G, van der Marel, Gijsbert A, Codée, Jeroen D. C, Overkleeft, Herman S

“…In this paper, a new synthetic route toward 6-hydroxysphingosine and α-hydroxy ceramide is described. The synthesis employs a cross-metathesis to unite a…”
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