Search Results - "Wisniewski, Thomas"

Immunotherapeutic Approaches for Alzheimer’s Disease by Wisniewski, Thomas, Goñi, Fernando

“…Alzheimer’s disease (AD) is the most prevalent form of dementia worldwide and is an emerging global epidemic. It is characterized by an imbalance between…”
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APOE-amyloid interaction: Therapeutic targets by Wisniewski, Thomas, Drummond, Eleanor

“…Alzheimer's disease (AD) is a devastating neurodegenerative disorder that is growing in prevalence globally. It is the only major cause of death without any…”
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Active immunotherapy for Alzheimer's disease by Wisniewski, Thomas

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Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts by Willhite, Calvin C., Karyakina, Nataliya A., Yokel, Robert A., Yenugadhati, Nagarajkumar, Wisniewski, Thomas M., Arnold, Ian M.F., Momoli, Franco, Krewski, Daniel

“…Abstract Aluminum (Al) is a ubiquitous substance encountered both naturally (as the third most abundant element) and intentionally (used in water, foods,…”
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Compilation of reported protein changes in the brain in Alzheimer’s disease by Askenazi, Manor, Kavanagh, Tomas, Pires, Geoffrey, Ueberheide, Beatrix, Wisniewski, Thomas, Drummond, Eleanor

“…Proteomic studies of human Alzheimer’s disease brain tissue have potential to identify protein changes that drive disease, and to identify new drug targets…”
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Amyloid-β immunisation for Alzheimer's disease by Wisniewski, Thomas, MBBS, Konietzko, Uwe, PhD

“…Summary Alzheimer's disease is the main cause of dementia in elderly people and is becoming an ever greater problem as societies worldwide age. Treatments that…”
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Tau-based therapeutic approaches for Alzheimer's disease - a mini-review by Boutajangout, Allal, Wisniewski, Thomas

“…The accumulation of aggregated, hyperphosphorylated tau as neurofibrillary tangles and neuropil threads are cardinal features of Alzheimer's disease (AD). The…”
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Recent advancements toward therapeutic vaccines against Alzheimer's disease by Herline, Krystal, Drummond, Eleanor, Wisniewski, Thomas

“…Alzheimer's disease (AD) is a devastating neurodegenerative disease characterized by protein aggregates of amyloid β (Aβ) and tau. These proteins have normal…”
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In vivo mapping of hippocampal venous vasculature and oxygenation using susceptibility imaging at 7T by Li, Chenyang, Buch, Sagar, Sun, Zhe, Muccio, Marco, Jiang, Li, Chen, Yongsheng, Haacke, E. Mark, Zhang, Jiangyang, Wisniewski, Thomas M., Ge, Yulin

“…•Venous arch structures of hippocampus are shown using high resolution SWI at 7T.•Hippocampal venous density is calculated to characterize hippocampal oxygen…”
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Traumatic Brain Injury and Alzheimer's Disease: The Cerebrovascular Link by Ramos-Cejudo, Jaime, Wisniewski, Thomas, Marmar, Charles, Zetterberg, Henrik, Blennow, Kaj, de Leon, Mony J., Fossati, Silvia

“…Traumatic brain injury (TBI) and Alzheimer's disease (AD) are devastating neurological disorders, whose complex relationship is not completely understood…”
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Isolation of Amyloid Plaques and Neurofibrillary Tangles from Archived Alzheimer's Disease Tissue Using Laser-Capture Microdissection for Downstream Proteomics by Drummond, Eleanor, Nayak, Shruti, Pires, Geoffrey, Ueberheide, Beatrix, Wisniewski, Thomas

“…Here, we describe a new method that allows localized proteomics of amyloid plaques and neurofibrillary tangles (NFTs), which are the two pathological hallmarks…”
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Demographic and social determinants of cognitive dysfunction following hospitalization for COVID-19 by Valdes, Eduard, Fuchs, Benjamin, Morrison, Chris, Charvet, Leigh, Lewis, Ariane, Thawani, Sujata, Balcer, Laura, Galetta, Steven L., Wisniewski, Thomas, Frontera, Jennifer A.

“…Persistent cognitive symptoms have been reported following COVID-19 hospitalization. We investigated the relationship between demographics, social determinants…”
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In Vivo Detection of Age-Related Tortuous Cerebral Small Vessels using Ferumoxytol-enhanced 7T MRI by Sun, Zhe, Li, Chenyang, Wisniewski, Thomas W, Haacke, E Mark, Ge, Yulin

“…Histopathological studies suggest that cerebral small vessel tortuosity is crucial in age-related blood flow reduction and cellular degeneration. However, in…”
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Down syndrome and Alzheimer's disease: Common pathways, common goals by Hartley, Dean, Blumenthal, Thomas, Carrillo, Maria, DiPaolo, Gilbert, Esralew, Lucille, Gardiner, Katheleen, Granholm, Ann-Charlotte, Iqbal, Khalid, Krams, Michael, Lemere, Cynthia, Lott, Ira, Mobley, William, Ness, Seth, Nixon, Ralph, Potter, Huntington, Reeves, Roger, Sabbagh, Marwan, Silverman, Wayne, Tycko, Benjamin, Whitten, Michelle, Wisniewski, Thomas

“…Abstract In the United States, estimates indicate there are between 250,000 and 400,000 individuals with Down syndrome (DS), and nearly all will develop…”
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Age-Related Tortuosity of Carotid and Vertebral Arteries: Quantitative Evaluation With MR Angiography by Sun, Zhe, Jiang, Dengrong, Liu, Peiying, Muccio, Marco, Li, Chenyang, Cao, Yan, Wisniewski, Thomas M, Lu, Hanzhang, Ge, Yulin

“…The vascular tortuosity (VT) of the internal carotid artery (ICA), and vertebral artery (VA) can impact blood flow and neuronal function. However, few studies…”
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The Innate Immune System in Alzheimer's Disease by Boutajangout, Allal, Wisniewski, Thomas

“…Alzheimer’s disease (AD) is the leading cause for dementia in the world. It is characterized by two biochemically distinct types of protein aggregates: amyloid…”
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Post-acute sequelae of COVID-19 symptom phenotypes and therapeutic strategies: A prospective, observational study by Frontera, Jennifer A, Thorpe, Lorna E, Simon, Naomi M, de Havenon, Adam, Yaghi, Shadi, Sabadia, Sakinah B, Yang, Dixon, Lewis, Ariane, Melmed, Kara, Balcer, Laura J, Wisniewski, Thomas, Galetta, Steven L

“…Post-acute sequelae of COVID-19 (PASC) includes a heterogeneous group of patients with variable symptomatology, who may respond to different therapeutic…”
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Pilot study evaluating everolimus molecular mechanisms in tuberous sclerosis complex and focal cortical dysplasia by Leitner, Dominique F, Kanshin, Evgeny, Askenazi, Manor, Siu, Yik, Friedman, Daniel, Devore, Sasha, Jones, Drew, Ueberheide, Beatrix, Wisniewski, Thomas, Devinsky, Orrin

“…Tuberous sclerosis complex (TSC) and some focal cortical dysplasias (FCDs) are associated with dysfunctional mTOR signaling, resulting in increased cell growth…”
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Apolipoprotein E : Essential Catalyst of the Alzheimer Amyloid Cascade by Potter, Huntington, Wisniewski, Thomas

“…The amyloid cascade hypothesis remains a robust model of AD neurodegeneration. However, amyloid deposits contain proteins besides Aβ, such as apolipoprotein E…”
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The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes by Wegiel, Jerzy, Kuchna, Izabela, Nowicki, Krzysztof, Imaki, Humi, Wegiel, Jarek, Marchi, Elaine, Ma, Shuang Yong, Chauhan, Abha, Chauhan, Ved, Bobrowicz, Teresa Wierzba, de Leon, Mony, Louis, Leslie A. Saint, Cohen, Ira L., London, Eric, Brown, W. Ted, Wisniewski, Thomas

“…Autism is characterized by a broad spectrum of clinical manifestations including qualitative impairments in social interactions and communication, and…”
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