Search Results - "Wisnewski, Adam V."

Human IgG and IgA responses to COVID-19 mRNA vaccines by Wisnewski, Adam V, Campillo Luna, Julian, Redlich, Carrie A

“…SARS-CoV-2 spike antigen-specific IgG and IgA elicited by infection mediate viral neutralization and are likely an important component of natural immunity,…”
Get full text

Glutathione reactivity with aliphatic polyisocyanates by Wisnewski, Adam V, Liu, Jian

“…Isocyanate chemicals known to cause adverse health effects when inhaled are essential to making important products and are used in multiple industries…”
Get full text

Development and utilization of a surrogate SARS-CoV-2 viral neutralization assay to assess mRNA vaccine responses by Wisnewski, Adam V, Liu, Jian, Lucas, Carolina, Klein, Jon, Iwasaki, Akiko, Cantley, Linda, Fazen, Louis, Campillo Luna, Julian, Slade, Martin, Redlich, Carrie A

“…Tests for SARS-CoV-2 immunity are needed to help assess responses to vaccination, which can be heterogeneous and may wane over time. The plaque reduction…”
Get full text

Automation of sample preparation for mass cytometry barcoding in support of clinical research: protocol optimization by Nassar, Ala F., Wisnewski, Adam V., Raddassi, Khadir

“…Analysis of multiplexed assays is highly important for clinical diagnostics and other analytical applications. Mass cytometry enables multi-dimensional,…”
Get full text

Immunogenic amino acid motifs and linear epitopes of COVID-19 mRNA vaccines by Wisnewski, Adam V, Redlich, Carrie A, Liu, Jian, Kamath, Kathy, Abad, Queenie-Ann, Smith, Richard F, Fazen, Louis, Santiago, Romero, Campillo Luna, Julian, Martinez, Brian, Baum-Jones, Elizabeth, Waitz, Rebecca, Haynes, Winston A, Shon, John C

“…Reverse vaccinology is an evolving approach for improving vaccine effectiveness and minimizing adverse responses by limiting immunizations to critical…”
Get full text

Associations of SARS-CoV-2 serum IgG with occupation and demographics of military personnel by Zell, Joseph, Wisnewski, Adam V, Liu, Jian, Klein, Jon, Lucas, Carolina, Slade, Martin, Iwasaki, Akiko, Redlich, Carrie A

“…Countries across the globe have mobilized their armed forces in response to COVID-19, placing them at increased risk for viral exposure. Humoral responses to…”
Get full text

Mass cytometry moving forward in support of clinical research: advantages and considerations by Nassar, Ala F, Wisnewski, Adam V, Raddassi, Khadir

Get full text

Lung Gene Expression Suggests Roles for Interferon-Stimulated Genes and Adenosine Deaminase Acting against RNA‑1 in Pathologic Responses to Diisocyanate by Wisnewski, Adam V., Liu, Jian

“…Mechanisms underlying methylene diphenyl diisocyanate (MDI) and other low molecular weight chemical-induced asthma are unclear and appear distinct from those…”
Get full text

Respiratory Symptoms, Sensitization, and Exposure Response Relationships in Spray Painters Exposed to Isocyanates by Pronk, Anjoeka, Preller, Liesbeth, Raulf-Heimsoth, Monika, Jonkers, Irene C. L, Lammers, Jan-Willem, Wouters, Inge M, Doekes, Gert, Wisnewski, Adam V, Heederik, Dick

“…Associations between oligomeric isocyanate exposure, sensitization, and respiratory disease have received little attention, despite the extensive use of…”
Get full text

Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory: Initial one-year follow-up by Gui, Wei, Wisnewski, Adam V., Neamtiu, Iulia, Gurzau, Eugen, Sparer, Judith A., Stowe, Meredith H., Liu, Jian, Slade, Martin D., Rusu, Olivia A., Redlich, Carrie A.

“…Background Isocyanates are one of the most commonly reported causes of occupational asthma; however, the risks of developing isocyanate asthma in modern…”
Get full text

Vapor conjugation of toluene diisocyanate to specific lysines of human albumin by Hettick, Justin M., Siegel, Paul D., Green, Brett J., Liu, Jian, Wisnewski, Adam V.

“…Exposure to toluene diisocyanate (TDI), an industrially important crosslinking agent used in the production of polyurethane products, can cause asthma in…”
Get full text

Pathogenesis and Disease Mechanisms of Occupational Asthma by Lummus, Zana L., PhD, Wisnewski, Adam V., PhD, Bernstein, David I., MD

“…Occupational asthma (OA) is one of the most common forms of work-related lung disease in all industrialized nations. The clinical management of patients with…”
Get full text

UPLC–MS for metabolomics: a giant step forward in support of pharmaceutical research by Nassar, Ala F., Wu, Terence, Nassar, Samuel F., Wisnewski, Adam V.

“…•Metabolomics provides a very powerful tool in pharmaceutical and clinical research.•Metabolomic biomarkers can improve personalized treatments.•Metabolomics…”
Get full text

Delayed production of neutralizing antibodies correlates with fatal COVID-19 by Lucas, Carolina, Klein, Jon, Sundaram, Maria E., Liu, Feimei, Wong, Patrick, Silva, Julio, Mao, Tianyang, Oh, Ji Eun, Mohanty, Subhasis, Huang, Jiefang, Tokuyama, Maria, Lu, Peiwen, Venkataraman, Arvind, Park, Annsea, Israelow, Benjamin, Vogels, Chantal B. F., Muenker, M. Catherine, Chang, C-Hong, Casanovas-Massana, Arnau, Moore, Adam J., Zell, Joseph, Fournier, John B., Wyllie, Anne L., Campbell, Melissa, Lee, Alfred I., Chun, Hyung J., Grubaugh, Nathan D., Schulz, Wade L., Farhadian, Shelli, Dela Cruz, Charles, Ring, Aaron M., Shaw, Albert C., Wisnewski, Adam V., Yildirim, Inci, Ko, Albert I., Omer, Saad B., Iwasaki, Akiko

“…Recent studies have provided insights into innate and adaptive immune dynamics in coronavirus disease 2019 (COVID-19). However, the exact features of antibody…”
Get full text

Analysis of Lung Gene Expression Reveals a Role for Cl - Channels in Diisocyanate-induced Airway Eosinophilia in a Mouse Model of Asthma Pathology by Wisnewski, Adam V, Liu, Jian, Redlich, Carrie A

“…Diisocyanates are well-recognized causes of asthma. However, sensitized workers frequently lack diisocyanate-specific IgE, which complicates diagnosis and…”
Get full text

Severe asthma and death in a worker using methylene diphenyl diisocyanate MDI asthma death by Wisnewski, Adam V., Cooney, Ryan, Hodgson, Michael, Giese, Kristinza, Liu, Jian, Redlich, Carrie A.

“…Diisocyanates are well‐recognized to cause occupational asthma, yet diisocyanate asthma can be challenging to diagnose and differentiate from asthma induced by…”
Get full text

Reply to letter to the editor concerning Gui et al. Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory by Wisnewski, Adam V., Redlich, Carrie A.

Get full text

A novel mouse model of diisocyanate-induced asthma showing allergic-type inflammation in the lung after inhaled antigen challenge by Herrick, Christina A., Xu, Lan, Wisnewski, Adam V., Das, Jyoti, Redlich, Carrie A., Bottomly, Kim

“…Background: Exposure to diisocyanates, a group of highly reactive, low-molecular-weight compounds, is a major cause of occupational asthma. In contrast to…”
Get full text

Dilysine-Methylene Diphenyl Diisocyanate (MDI), a Urine Biomarker of MDI Exposure? by Wisnewski, Adam V, Nassar, Ala F, Liu, Jian, Bello, Dhimiter

“…Biomonitoring of methylene diphenyl diisocyanate (MDI) in urine may be useful in industrial hygiene and exposure surveillance approaches toward disease…”
Get full text

Immune sensitization to methylene diphenyl diisocyanate (MDI) resulting from skin exposure: albumin as a carrier protein connecting skin exposure to subsequent respiratory responses by Wisnewski, Adam V, Xu, Lan, Robinson, Eve, Liu, Jian, Redlich, Carrie A, Herrick, Christina A

“…Methylene diphenyl diisocyanate (MDI), a reactive chemical used for commercial polyurethane production, is a well-recognized cause of occupational asthma. The…”
Get full text