Search Results - "Wiseman, K."

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome by Wiseman, Frances K., Al-Janabi, Tamara, Hardy, John, Karmiloff-Smith, Annette, Nizetic, Dean, Tybulewicz, Victor L. J., Fisher, Elizabeth M. C., Strydom, André

“…Individuals with Down syndrome have an enhanced risk of developing early onset Alzheimer disease. Here, the authors describe the features of Alzheimer disease…”
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Rodent Modeling of Alzheimer's Disease in Down Syndrome: In vivo and ex vivo Approaches by Farrell, Clíona, Mumford, Paige, Wiseman, Frances K.

“…There are an estimated 6 million people with Down syndrome (DS) worldwide. In developed countries, the vast majority of these individuals will develop…”
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Endosomal structure and APP biology are not altered in a preclinical mouse cellular model of Down syndrome by Cannavo, Claudia, Cleverley, Karen, Maduro, Cheryl, Mumford, Paige, Moulding, Dale, Fisher, Elizabeth M C, Wiseman, Frances K

“…Individuals who have Down syndrome (trisomy 21) are at greatly increased risk of developing Alzheimer's disease, characterised by the accumulation in the brain…”
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Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease by Startin, Carla M, Ashton, Nicholas J, Hamburg, Sarah, Hithersay, Rosalyn, Wiseman, Frances K, Mok, Kin Y, Hardy, John, Lleó, Alberto, Lovestone, Simon, Parnetti, Lucilla, Zetterberg, Henrik, Hye, Abdul, Strydom, André

“…Down syndrome (DS), caused by chromosome 21 trisomy, is associated with an ultra-high risk of dementia due to Alzheimer's disease (AD), driven by amyloid…”
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Massively parallel sequencing reveals the complex structure of an irradiated human chromosome on a mouse background in the Tc1 model of Down syndrome by Gribble, Susan M, Wiseman, Frances K, Clayton, Stephen, Prigmore, Elena, Langley, Elizabeth, Yang, Fengtang, Maguire, Sean, Fu, Beiyuan, Rajan, Diana, Sheppard, Olivia, Scott, Carol, Hauser, Heidi, Stephens, Philip J, Stebbings, Lucy A, Ng, Bee Ling, Fitzgerald, Tomas, Quail, Michael A, Banerjee, Ruby, Rothkamm, Kai, Tybulewicz, Victor L J, Fisher, Elizabeth M C, Carter, Nigel P

“…Down syndrome (DS) is caused by trisomy of chromosome 21 (Hsa21) and presents a complex phenotype that arises from abnormal dosage of genes on this chromosome…”
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Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome by Chang, Pishan, Bush, Daniel, Schorge, Stephanie, Good, Mark, Canonica, Tara, Shing, Nathanael, Noy, Suzanna, Wiseman, Frances K., Burgess, Neil, Tybulewicz, Victor L.J., Walker, Matthew C., Fisher, Elizabeth M.C.

“…Altered neural dynamics in the medial prefrontal cortex (mPFC) and hippocampus may contribute to cognitive impairments in the complex chromosomal disorder Down…”
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The effects of Cstb duplication on APP/amyloid-β pathology and cathepsin B activity in a mouse model by Wu, Yixing, Whittaker, Heather T, Noy, Suzanna, Cleverley, Karen, Brault, Veronique, Herault, Yann, Fisher, Elizabeth M C, Wiseman, Frances K

“…People with Down syndrome (DS), caused by trisomy of chromosome 21 have a greatly increased risk of developing Alzheimer's disease (AD). This is in part…”
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Down syndrome—recent progress and future prospects by Wiseman, Frances K., Alford, Kate A., Tybulewicz, Victor L.J., Fisher, Elizabeth M.C.

“…Down syndrome (DS) is caused by trisomy of chromosome 21 (Hsa21) and is associated with a number of deleterious phenotypes, including learning disability,…”
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Developing logistic regression models using purchase attributes and demographics to predict the probability of purchases of regular and specialty eggs by Bejaei, M, Wiseman, K, Cheng, K. M

“…Consumers’ interest in specialty eggs appears to be growing in Europe and North America. The objective of this research was to develop logistic regression…”
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Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models by Tosh, Justin L., Rhymes, Elena R., Mumford, Paige, Whittaker, Heather T., Pulford, Laura J., Noy, Sue J., Cleverley, Karen, Walker, Matthew C., Tybulewicz, Victor L. J., Wykes, Rob C., Fisher, Elizabeth M. C., Wiseman, Frances K.

“…Individuals who have Down syndrome (caused by trisomy of chromosome 21), have a greatly elevated risk of early-onset Alzheimer’s disease, in which amyloid-β…”
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Substantially thinner internal granular layer and reduced molecular layer surface in the cerebellar cortex of the Tc1 mouse model of down syndrome – a comprehensive morphometric analysis with active staining contrast-enhanced MRI by Ma, Da, Cardoso, Manuel J., Zuluaga, Maria A., Modat, Marc, Powell, Nick M., Wiseman, Frances K., Cleary, Jon O., Sinclair, Benjamin, Harrison, Ian F., Siow, Bernard, Popuri, Karteek, Lee, Sieun, Matsubara, Joanne A., Sarunic, Marinko V., Beg, Mirza Faisal, Tybulewicz, Victor L.J., Fisher, Elizabeth M.C., Lythgoe, Mark F., Ourselin, Sebastien

“…Down Syndrome is a chromosomal disorder that affects the development of cerebellar cortical lobules. Impaired neurogenesis in the cerebellum varies among…”
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Registered Replication Report: Schooler and Engstler-Schooler (1990) by Alogna, V. K., Attaya, M.K., Aucoin, P., Bahnik, Š., Birch, S., Birt, A. R., Bornstein, B. H., Bouwmeester, S., Brandimonte, M. A., Brown, C., Buswell, K., Carlson, C., Carlson, M., Chu, S., Cislak, A., Colarusso, M., Colloff, M. F., Dellapaolera, K.S., Delvenne, J.-F., Di Domenico, A., Drummond, A., Echterhoff, G., Edlund, J. E., Eggleston, C. M., Fairfield, B., Franco, G., Gabbert, F., Gamblin, B. W., Garry, M., Gentry, R., Gilbert, E. A., Greenberg, D. L., Halberstadt, J., Hall, L., Hancock, P. J. B., Hirsch, D., Holt, G., Jackson, J. C., Jong, J., Kehn, A., Koch, C., Kopietz, R., Körner, U., Kunar, M. A., Lai, C. K., Langton, S. R. H., Leite, F. P., Mammarella, N., Marsh, J. E., McConnaughy, K. A., McCoy, S., McIntyre, A. H., Meissner, C. A., Michael, R.B., Mitchell, A.A., Mugayar-Baldocchi, M., Musselman, R., Ng, C., Nichols, A. L., Nunez, N. L., Palmer, M. A., Pappagianopoulos, J. E., Petro, M. S., Poirier, C. R., Portch, E., Rainsford, M., Rancourt, A., Romig, C., Rubínová, E., Sanson, M., Satchell, L., Sauer, J. D., Schweitzer, K., Shaheed, J., Skelton, F., Sullivan, G. A., Susa, K. J., Swanner, J. K., Thompson, W. B., Todaro, R., Ulatowska, J., Valentine, T., Verkoeijen, P. P. J. L., Vranka, M., Wade, K. A., Was, C. A., Weatherford, D., Wiseman, K., Zaksaite, T., Zuj, D. V., Zwaan, R. A.

“…Trying to remember something now typically improves your ability to remember it later. However, after watching a video of a simulated bank robbery,…”
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Cathepsin B abundance, activity and microglial localisation in Alzheimer's disease-Down syndrome and early onset Alzheimer's disease; the role of elevated cystatin B by Wu, Yixing, Mumford, Paige, Noy, Suzanna, Cleverley, Karen, Mrzyglod, Alicja, Luo, Dinghao, van Dalen, Floris, Verdoes, Martijn, Fisher, Elizabeth M C, Wiseman, Frances K

“…Cathepsin B is a cysteine protease that is implicated in multiple aspects of Alzheimer's disease pathogenesis. The endogenous inhibitor of this enzyme,…”
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Reaching adults who smoke cigarettes in rural Appalachia: Rationale, design & analysis plan for a mixed-methods study disseminating pharmacy-delivered cessation treatment by Fahey, M.C., Krukowski, R.A., Anderson, R.T., Cohn, W.F., Porter, K.J., Reid, T., Wiseman, K.P., You, W., Wood, C.H., Rucker, T.W., Little, M.A.

“…Unlike other U.S. geographical regions, cigarette smoking prevalence remains stagnant in rural Appalachia. One avenue for reaching rural residents with…”
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Publisher Correction: Genetic dissection of down syndrome‑associated alterations in APP/amyloid‑β biology using mouse models by Tosh, Justin L., Rhymes, Elena R., Mumford, Paige, Whittaker, Heather T., Pulford, Laura J., Noy, Sue J., Cleverley, Karen, Walker, Matthew C., Tybulewicz, Victor L. J., Wykes, Rob C., Fisher, Elizabeth M. C., Wiseman, Frances K.

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Cell models for Down syndrome-Alzheimer's disease research by Wu, Yixing, West, Nicole R, Bhattacharyya, Anita, Wiseman, Frances K

“…Down syndrome (DS) is the most common chromosomal abnormality and leads to intellectual disability, increased risk of cardiac defects, and an altered immune…”
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Chytrid infections exhibit historical spread and contemporary seasonality in a declining stream-breeding frog by Belasen, A M, Peek, R A, Adams, A J, Russell, I D, De León, M E, Adams, M J, Bettaso, J, Breedveld, K G H, Catenazzi, A, Dillingham, C P, Grear, D A, Halstead, B J, Johnson, P G, Kleeman, P M, Koo, M S, Koppl, C W, Lauder, J D, Padgett-Flohr, G, Piovia-Scott, J, Pope, K L, Vredenburg, V, Westphal, M, Wiseman, K, Kupferberg, S J

“…Species with extensive geographical ranges pose special challenges to assessing drivers of wildlife disease, necessitating collaborative and large-scale…”
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Influences of demographic characteristics, attitudes, and preferences of consumers on table egg consumption in British Columbia, Canada by Bejaei, M, Wiseman, K, Cheng, K.M

“…In addition to regular (white and brown) eggs, alternative types of table eggs (e.g., free-run, free-range, organic) are available in the Canadian market, and…”
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Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory by Hall, Jessica H., Wiseman, Frances K., Fisher, Elizabeth M.C., Tybulewicz, Victor L.J., Harwood, John L., Good, Mark A.

“…•Tc1 mice (a mouse model of Down syndrome) showed impaired short-term memory for object and olfactory stimuli. Both immediate and long-term memory remained…”
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Replication-timing boundaries facilitate cell-type and species-specific regulation of a rearranged human chromosome in mouse by POPE, Benjamin D, CHANDRA, Tamir, BUCKLEY, Quinton, HOARE, Matthew, RYBA, Tyrone, WISEMAN, Frances K, KUTA, Anna, WILSON, Michael D, ODOM, Duncan T, GILBERT, David M

“…In multicellular organisms, developmental changes to replication timing occur in 400-800 kb domains across half the genome. While examples of epigenetic…”
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