Search Results - "Wise, Stephen D"

Possible Differential Induction of Phase 2 Enzyme and Antioxidant Pathways by American Ginseng, Panax quinquefolius by Lee, Lawrence S., Wise, Stephen D., Chan, Clark, Parsons, Teresa L., Flexner, Charles, Lietman, Paul S.

“…Human immunodeficiency virus (HIV)‐infected patients often take herbal medicines, which may interact with antiretrovirals. American ginseng induces phase 2 and…”
Get full text

Effect of Exenatide on the Pharmacokinetics and Pharmacodynamics of Warfarin in Healthy Asian Men by Soon, Danny, Kothare, Prajakti A., Linnebjerg, Helle, Park, Soomin, Yuen, Eunice, Mace, Kenneth F., Wise, Stephen D.

“…Exenatide, a treatment for type 2 diabetes, slows gastric emptying as part of its pharmacologic action and may alter the absorption of concomitant oral drugs…”
Get full text

Atomoxetine pharmacokinetics in healthy Chinese subjects and effect of the CYP2D610 allele by Cui, Yi M., Teng, Choo H., Pan, Alan X., Yuen, Eunice, Yeo, Kwee P., Zhou, Ying, Zhao, Xia, Long, Amanda J., Bangs, Mark E., Wise, Stephen D.

“…What is already known about this subject • Atomoxetine is a cytochrome P450 2D6 (CYP2D6) substrate and its pharmacokinetics has been characterized in a…”
Get full text

A Review and Assessment of Potential Sources of Ethnic Differences in Drug Responsiveness by Bjornsson, Thorir D., Wagner, John A., Donahue, Stephen R., Harper, Dawn, Karim, Aziz, Khouri, Marlene S., Murphy, William R., Roman, Kristin, Schneck, Dennis, Sonnichsen, Daryl S., Stalker, Dennis J., Wise, Stephen D., Dombey, Stuart, Loew, Caroline

“…The International Conference on Harmonization (ICH) E5 guidelines were developed to provide a general framework for evaluating the potential impact of ethnic…”
Get full text

Effect of Exenatide on the Steady-State Pharmacokinetics of Digoxin by Kothare, Prajakti A., Soon, Danny K. W., Linnebjerg, Helle, Park, Soomin, Chan, Clark, Yeo, Adeline, Lim, Maggie, Mace, Kenneth F., Wise, Stephen D.

“…This open‐label study investigated the effect of exenatide coadministration on the steady‐state plasma pharmacokinetics of digoxin. A total of 21 healthy male…”
Get full text

Olanzapine pharmacokinetics are similar in Chinese and Caucasian subjects by Sathirakul, Korbtham, Chan, Clark, Teng, Leyan, Bergstrom, Richard F., Yeo, Kwee Poo, Wise, Stephen D.

“…Aim  To compare the pharmacokinetic profiles and dose proportionality of olanzapine in Chinese and Caucasian subjects. Methods  Randomized, three‐period study…”
Get full text

Clinical Pharmacokinetics of Alamifovir and Its Metabolites by CHAN, Clark, ABU-RADDAD, Eyas, WISE, Stephen D, GOLOR, Georg, WATANABE, Hikari, SASAKI, Akira, KWEE POO YEO, SOON, Danny, SINHA, Vikram P, FLANAGAN, Shawn D, HE, Minxia M

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Duloxetine is both an inhibitor and a substrate of cytochrome P4502D6 in healthy volunteers by Skinner, Michael H., Kuan, Han‐Yi, Pan, Alan, Sathirakul, Korbtham, Knadler, Mary Pat, Gonzales, Celedon R., Yeo, Kwee Poo, Reddy, Shobha, Lim, Maggie, Ayan‐Oshodi, Mosun, Wise, Stephen D.

“…Background and Objectives Duloxetine, a potent dual reuptake inhibitor of serotonin and norepinephrine currently undergoing clinical investigation for…”
Get full text

Modeling and simulations to confirm a controlled hypoglycemic stress test in healthy subjects is not associated with clinically significant QT prolongations by Tham, Lai San, Fen Zhao, Crystal Mei, Natanegara, Fanni, Lowe, Stephen, Chen, Christopher, Lim, Chay Ngee, Linnebjerg, Helle, Willis, Brian A, Mitchell, Malcolm I, Wise, Stephen D

“…A modified insulin tolerance test (ITT) can be used to simulate a physiological stress state through the induction of controlled hypoglycemia in healthy…”
Get full text

Lack of effect of acute oral ingestion of vitamin C on oxidative stress, arterial stiffness or blood pressure in healthy subjects by Kelly, Ronan P, Poo Yeo, Kwee, Isaac, Helen B, Lee, Chung-Yung J, Huang, Shan Hong, Teng, Lorraine, Halliwell, Barry, Wise, Stephen D

“…Vitamin C is a potent antioxidant in vitro and has been reported to act as a vasodilator, possibly by increasing nitric oxide bioavailability. This study…”
Get more information

The effects on metabolic clearance when administering a potent CYP3A autoinducer with the prototypic CYP3A inhibitor, ketoconazole by Ayan-Oshodi, Mosun A, Willis, Brian A, Annes, William F, Lowe, Stephen L, Friedrich, Stuart, de la Peña, Amparo, Zhang, Wei, Brown, Thomas, Wise, Stephen D, Hall, Stephen D

“…Ketoconazole is recognized as the prototypical CYP3A inhibitor and is often used to determine the metabolic CYP3A liabilities of new chemical entities in…”
Get full text

Modeling and simulations to confirm that a controlled hypoglycemic stress test in healthy subjects is not associated with clinically significant QT prolongations by LAI SAN THAM, MEI FEN ZHAO, Crystal, NATANEGARA, Fanni, LOWE, Stephen, CHEN, Christopher, CHAY NGEE LIM, LINNEBJERG, Helle, WILLIS, Brian A, MITCHELL, Malcolm I, WISE, Stephen D

Get full text

Insulin-Like Growth Factor Binding Protein-1 Is Independently Affected by Ethnicity, Insulin Sensitivity, and Leptin in Healthy, Glucose-Tolerant Young Men by Liew, Choon F., Wise, Stephen D., Yeo, Kwee P., Lee, Kok O.

“…We examined the relationships among IGF binding protein (IGFBP)-1, insulin sensitivity, and leptin in different ethnic groups (Asian Indians, Chinese, and…”
Get full text

Bioassays for estrogenic activity: development and validation of estrogen receptor (ERalpha/ERbeta) and breast cancer proliferation bioassays to measure serum estrogenic activity in clinical studies by Li, J, Lee, L, Gong, Y, Shen, P, Wong, S P, Wise, Stephen D, Yong, E L

“…Standard estrogenic prodrugs such as estradiol valerate (E2V) and increasingly popular phytoestrogen formulations are commonly prescribed to improve menopausal…”
Get more information

Effects of smoking cessation, acute re‐exposure and nicotine replacement in smokers on AIR® inhaled insulin pharmacokinetics and glucodynamics by Pan, Alan X., De La Peña, Amparo, Yeo, Kwee P., Chan, Clark, Loh, Mei T., Wise, Stephen D., Silverman, Bernard L., Muchmore, Douglas B.

“…What is already known about this subject • Only one other study (Becker et al.) has reported on the influence of smoking cessation and smoking resumption on…”
Get full text

l-5-Hydroxytryptophan augments the neuroendocrine response to a SSRI by Lowe, Stephen L., Poo Yeo, Kwee, Teng, Leyan, Soon, Danny K.W., Pan, Alan, Wise, Stephen D., Peck, Richard W.

“…The objective of the study was to assess l-5-hydroxytryptophan's ( l-5HTP) augmentation effect on the neuroendocrine response to a SSRI (citalopram). A…”
Get full text

Hemodynamic Effects of Acute Administration of Atomoxetine and Methylphenidate by Kelly, Ronan P., Yeo, Kwee Poo, Teng, Choo-Hua, Smith, Brian P., Lowe, Stephen, Soon, Danny, Read, Holly A., Wise, Stephen D.

Get full text

Safety and efficacy of alamifovir in patients with chronic hepatitis B virus infection by Soon, Danny K.W., Lowe, Stephen L., Teng, Choo Hua, Yeo, Kwee Poo, McGill, James, Wise, Stephen D.

“…Alamifovir is a purine nucleotide analogue prodrug that shows potent activity against wild type and lamivudine resistant hepatitis B virus in preclinical…”
Get full text

Effect of duloxetine on tolterodine pharmacokinetics in healthy volunteers by Hua, Teng C., Pan, Alan, Chan, Clark, Poo, Yeo K., Skinner, Michael H., Knadler, Mary P., Gonzales, Celedon R., Wise, Stephen D.

“…Aim To investigate the effect of duloxetine on the pharmacokinetics and tolerability of tolterodine and its active 5‐hydroxymethyl metabolite (5‐HM). Methods…”
Get full text

Pharmacokinetics of ruboxistaurin are significantly altered by rifampicin‐mediated CYP3A4 induction by Yeo, Kwee Poo, Lowe, Stephen L., Lim, Ming Tung, Voelker, James R., Burkey, Jennifer L., Wise, Stephen D.

“…Aims The aim of this study was to evaluate the effect of rifampicin co‐administration on the pharmacokinetics of ruboxistaurin and its active metabolite,…”
Get full text