Search Results - "Wise, Bruce E"

Pilot Plant Preparation of an αvβ3 Integrin Antagonist. Part 1. Process Research and Development of a (S)-β-Amino Acid Ester Intermediate:  Synthesis via a Scalable, Diastereoselective Imino-Reformatsky Reaction by Clark, Jerry D, Weisenburger, Gerald A, Anderson, D. Keith, Colson, Pierre-Jean, Edney, Albert D, Gallagher, Donald J, Kleine, H. Peter, Knable, Carl M, Lantz, Melissa K, Moore, Christine M. V, Murphy, James B, Rogers, Thomas E, Ruminski, Peter G, Shah, Ajit S, Storer, Neil, Wise, Bruce E

“…Described are four process research investigations directed toward discerning a scalable, enantioselective method for preparing (S)-β-amino acid ester 3, a key…”
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Pilot-Plant Preparation of an αvβ3 Integrin Antagonist. Part 3. Process Research and Development of a Diisopropylcarbodiimide and Catalytic 1-Hydroxybenzotriazole Peptide Coupling by Clark, Jerry D, Anderson, D. Keith, Banaszak, David V, Brown, Derek B, Czyzewski, Ann M, Edeny, Albert D, Forouzi, Puneh S, Gallagher, Donald J, Iskos, V. H, Kleine, H. Peter, Knable, Carl M, Lantz, Melissa K, Lapack, Mark A, Moore, Christine M. V, Muellner, Frank W, Murphy, James B, Orihuela, Carlos A, Pietz, Mark A, Rogers, Thomas E, Ruminski, Peter G, Santhanam, Harish K, Schilke, Tobin C, Shah, Ajit S, Sheikh, Ahmad Y, Weisenburger, Gerald A, Wise, Bruce E

“…Studies directed toward the process research, development, and scale-up preparation of the potential αvβ3 integrin antagonist 1 are described. A convergent…”
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Pilot-Plant Preparation of an α v β 3 Integrin Antagonist. Part 3. Process Research and Development of a Diisopropylcarbodiimide and Catalytic 1-Hydroxybenzotriazole Peptide Coupling by Clark, Jerry D., Anderson, D. Keith, Banaszak, David V., Brown, Derek B., Czyzewski, Ann M., Edeny, Albert D., Forouzi, Puneh S., Gallagher, Donald J., Iskos, V. H., Kleine, H. Peter, Knable, Carl M., Lantz, Melissa K., Lapack, Mark A., Moore, Christine M. V., Muellner, Frank W., Murphy, James B., Orihuela, Carlos A., Pietz, Mark A., Rogers, Thomas E., Ruminski, Peter G., Santhanam, Harish K., Schilke, Tobin C., Shah, Ajit S., Sheikh, Ahmad Y., Weisenburger, Gerald A., Wise, Bruce E.

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Pilot Plant Preparation of an α v β 3 Integrin Antagonist. Part 1. Process Research and Development of a ( S )-β-Amino Acid Ester Intermediate:  Synthesis via a Scalable, Diastereoselective Imino-Reformatsky Reaction by Clark, Jerry D., Weisenburger, Gerald A., Anderson, D. Keith, Colson, Pierre-Jean, Edney, Albert D., Gallagher, Donald J., Kleine, H. Peter, Knable, Carl M., Lantz, Melissa K., Moore, Christine M. V., Murphy, James B., Rogers, Thomas E., Ruminski, Peter G., Shah, Ajit S., Storer, Neil, Wise, Bruce E.

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An efficient asymmetric synthesis of (3 S)-3-amino-1-(4-cyanophenyl)-2-oxopyrrolidine hydrochloride salt by Colson, Pierre-Jean, Przybyla, Claire A., Wise, Bruce E., Babiak, Kevin A., Seaney, Lisa M., Korte, Donald E.

“…Reaction of 4-aminobenzonitrile with 2-bromo-4-chlorobutyryl bromide in the presence of sodium phosphate followed by treatment of the coupled product with…”
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