Search Results - "Winzeler, Elizabeth"

New targets for antimalarial drug discovery by Guerra, Francisco, Winzeler, Elizabeth A

“…Phenotypic screening methods have placed numerous preclinical candidates into the antimalarial drug-discovery pipeline. As more chemically validated targets…”
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The antimalarial resistome – finding new drug targets and their modes of action by Carolino, Krypton, Winzeler, Elizabeth A

“…•In-vitro evolution and whole genome sequencing elucidates gene–drug interactions.•Cellular thermal shift assay and mass spectrometry directly reveals small…”
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Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection by Ma, Shang, Cahalan, Stuart, LaMonte, Gregory, Grubaugh, Nathan D., Zeng, Weizheng, Murthy, Swetha E., Paytas, Emma, Gamini, Ramya, Lukacs, Viktor, Whitwam, Tess, Loud, Meaghan, Lohia, Rakhee, Berry, Laurence, Khan, Shahid M., Janse, Chris J., Bandell, Michael, Schmedt, Christian, Wengelnik, Kai, Su, Andrew I., Honore, Eric, Winzeler, Elizabeth A., Andersen, Kristian G., Patapoutian, Ardem

“…Hereditary xerocytosis is thought to be a rare genetic condition characterized by red blood cell (RBC) dehydration with mild hemolysis. RBC dehydration is…”
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A roadmap for malaria research by Winzeler, Elizabeth A

“…Single-cell profiling of parasite species provides an atlas of life cycle–coordinated gene expression Although malaria is one of the most prevalent infectious…”
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The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites by Delves, Michael, Plouffe, David, Scheurer, Christian, Meister, Stephan, Wittlin, Sergio, Winzeler, Elizabeth A, Sinden, Robert E, Leroy, Didier

“…Malaria remains a disease of devastating global impact, killing more than 800,000 people every year-the vast majority being children under the age of 5. While…”
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Antimalarial drug discovery — approaches and progress towards new medicines by Flannery, Erika L., Chatterjee, Arnab K., Winzeler, Elizabeth A.

“…Key Points Although malaria continues to affect 40% of the world's population and is estimated to be responsible for up to 1 million deaths per year, the…”
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Genomic Approaches to Drug Resistance in Malaria by Rocamora, Frances, Winzeler, Elizabeth A

“…Although the last two decades have seen a substantial decline in malaria incidence and mortality due to the use of insecticide-treated bed nets and artemisinin…”
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Advances in omics-based methods to identify novel targets for malaria and other parasitic protozoan infections by Cowell, Annie N, Winzeler, Elizabeth A

“…A major advance in antimalarial drug discovery has been the shift towards cell-based phenotypic screening, with notable progress in the screening of compounds…”
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malERA: An updated research agenda for malaria elimination and eradication by Rabinovich, Regina N, Drakeley, Chris, Djimde, Abdoulaye A, Hall, B Fenton, Hay, Simon I, Hemingway, Janet, Kaslow, David C, Noor, Abdisalan, Okumu, Fredros, Steketee, Richard, Tanner, Marcel, Wells, Timothy N C, Whittaker, Maxine A, Winzeler, Elizabeth A, Wirth, Dyann F, Whitfield, Kate, Alonso, Pedro L

“…Achieving a malaria-free world presents exciting scientific challenges as well as overwhelming health, equity, and economic benefits. WHO and countries are…”
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The genomic architecture of antimalarial drug resistance by Cowell, Annie N, Winzeler, Elizabeth A

“…Plasmodium falciparum and Plasmodium vivax, the two protozoan parasite species that cause the majority of cases of human malaria, have developed resistance to…”
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An improbable journey: Creativity helped me make the transition from art to curing malaria by Winzeler, Elizabeth A.

“…I was recently awarded the Alice and C. C. Wang Award in Molecular Parasitology for my contributions to antimalarial drug development, including laying the…”
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Antimalarial drug discovery: progress and approaches by Siqueira-Neto, Jair L., Wicht, Kathryn J., Chibale, Kelly, Burrows, Jeremy N., Fidock, David A., Winzeler, Elizabeth A.

“…Recent antimalarial drug discovery has been a race to produce new medicines that overcome emerging drug resistance, whilst considering safety and improving…”
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Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents by Stokes, Barbara H, Yoo, Euna, Murithi, James M, Luth, Madeline R, Afanasyev, Pavel, da Fonseca, Paula C A, Winzeler, Elizabeth A, Ng, Caroline L, Bogyo, Matthew, Fidock, David A

“…Therapeutics with novel modes of action and a low risk of generating resistance are urgently needed to combat drug-resistant Plasmodium falciparum malaria…”
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The proteasome as a target: How not tidying up can have toxic consequences for parasitic protozoa by Winzeler, Elizabeth A., Ottilie, Sabine

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Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families by Bopp, Selina E R, Manary, Micah J, Bright, A Taylor, Johnston, Geoffrey L, Dharia, Neekesh V, Luna, Fabio L, McCormack, Susan, Plouffe, David, McNamara, Case W, Walker, John R, Fidock, David A, Denchi, Eros Lazzerini, Winzeler, Elizabeth A

“…Malaria parasites elude eradication attempts both within the human host and across nations. At the individual level, parasites evade the host immune responses…”
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Na+ Regulation in the Malaria Parasite Plasmodium falciparum Involves the Cation ATPase PfATP4 and Is a Target of the Spiroindolone Antimalarials by Spillman, Natalie J., Allen, Richard J.W., McNamara, Case W., Yeung, Bryan K.S., Winzeler, Elizabeth A., Diagana, Thierry T., Kirk, Kiaran

“…The malaria parasite Plasmodium falciparum establishes in the host erythrocyte plasma membrane new permeability pathways that mediate nutrient uptake into the…”
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Drug resistance genomics of the antimalarial drug artemisinin by Winzeler, Elizabeth A, Manary, Micah J

“…Across the globe, over 200 million annual malaria infections result in up to 660,000 deaths, 77% of which occur in children under the age of five years…”
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A Sleeping Area of Malaria Research Awakes by Winzeler, Elizabeth A.

“…Phenotypic screening methods have had a profound impact on antimalarial drug development, but assays that predict which compounds might provide a radical cure…”
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Glycophorin alleles link to malaria protection by Winzeler, Elizabeth A.

“…Genome-wide association studies identify variants in the human glycophorin ABE locus Malaria caused by Plasmodium falciparum remains a leading cause of…”
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Longitudinal study of Plasmodium pathogens identifies new loci associated with artemisinin resistance by Winzeler, Elizabeth A

“…A longitudinal analysis of malaria parasite genomes has revealed new markers that can be used in public health efforts to limit the spread of…”
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