Search Results - "Winter, Zoltan"
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KCNQ1 is an essential mediator of the sex-dependent perception of moderate cold temperatures
Published in Proceedings of the National Academy of Sciences - PNAS (18-06-2024)“…Low temperatures and cooling agents like menthol induce cold sensation by activating the peripheral cold receptors TRPM8 and TRPA1, cation channels belonging…”
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Cold Temperature Encoding by Cutaneous TRPA1 and TRPM8-Carrying Fibers in the Mouse
Published in Frontiers in molecular neuroscience (30-06-2017)“…Previous research identified TRPM8 and TRPA1 cold transducers with separate functions, one being functional in the non-noxious range and the second one being a…”
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Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain
Published in Toxins (17-03-2016)“…Loss-of-function mutations of Na(V)1.7 lead to congenital insensitivity to pain, a rare condition resulting in individuals who are otherwise normal except for…”
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Odontoblast TRPC5 channels signal cold pain in teeth
Published in Science advances (01-03-2021)“…Teeth are composed of many tissues, covered by an inflexible and obdurate enamel. Unlike most other tissues, teeth become extremely cold sensitive when…”
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Impact of dietary vitamin D on immunoregulation and disease pathology in lupus-prone NZB/W F1 mice
Published in Frontiers in immunology (24-11-2022)“…Vitamin D (VD) deficiency is a highly prevalent worldwide phenomenon and is extensively discussed as a risk factor for the development of systemic lupus…”
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3Dscript.server: true server-side 3D animation of microscopy images using a natural language-based syntax
Published in Bioinformatics (11-12-2021)“…Abstract Summary Creating 3D animations from microscopy data is computationally expensive and requires high-end hardware. We therefore developed…”
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NanoLuc Binary Technology as a methodological approach: an important new tool for studying the localization of androgen receptor and androgen receptor splice variant V7 homo and heterodimers
Published in BMC cancer (19-03-2024)“…The androgen/androgen receptor (AR)-signaling axis plays a central role in prostate cancer (PCa). Upon androgen-binding the AR dimerizes with another AR, and…”
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Functionally Important Amino Acid Residues in the Transient Receptor Potential Vanilloid 1 (TRPV1) Ion Channel - An Overview of the Current Mutational Data
Published in Molecular Pain (22-06-2013)“…This review aims to create an overview of the currently available results of site-directed mutagenesis studies on transient receptor potential vanilloid type 1…”
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Book Review Journal Article -
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Pellitorine, an extract of Tetradium daniellii, is an antagonist of the ion channel TRPV1
Published in Phytomedicine (Stuttgart) (15-10-2017)“…Transient Receptor Potential Vanilloid 1 (TRPV1) confers noxious heat and inflammatory pain signals in the peripheral nervous system. Clinical trial of…”
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Competitive inhibition of TRPV1–calmodulin interaction by vanilloids
Published in FEBS letters (01-08-2016)“…There is enormous interest toward vanilloid agonists of the pain receptor TRPV1 in analgesic therapy, but the mechanisms of their sensory neuron‐blocking…”
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Besides neuro-imaging, the Thy1-YFP mouse could serve for visualizing experimental tumours, inflammation and wound-healing
Published in Scientific reports (27-10-2014)“…The B6.Cg-Tg(Thy1-YFP)16Jrs/J transgenic mouse strain, widely used to study neuronal development and regeneration, expresses the yellow fluorescent protein…”
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Comprehensive thermal preference phenotyping in mice using a novel automated circular gradient assay
Published in Temperature (Austin) (02-01-2016)“…Currently available behavioral assays to quantify normal cold sensitivity, cold hypersensitivity and cold hyperalgesia in mice have betimes created conflicting…”
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New insights into lacrimal gland anatomy using 7T MRI and electron microscopy: Relevance for lacrimal gland targeted therapies and bioengineering
Published in The ocular surface (01-10-2023)“…To study the tissue architecture, isthmus (connection between two lobes) of the lacrimal gland using preclinical 7T MRI in combination with histology and…”
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Targeting of the Tec Kinase ITK Drives Resolution of T Cell–Mediated Colitis and Emerges as Potential Therapeutic Option in Ulcerative Colitis
Published in Gastroenterology (New York, N.Y. 1943) (01-10-2021)“…The molecular checkpoints driving T cell activation and cytokine responses in ulcerative colitis (UC) are incompletely understood. Here, we studied the Tec…”
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Resiniferatoxin mediated ablation of TRPV1+ neurons removes TRPA1 as well
Published in Canadian journal of neurological sciences (01-03-2009)“…Resiniferatoxin, the most potent agonist of inflammatory pain/vanilloid receptor/cation channel (TRPV1) can be used for neuron subtype specific ablation of…”
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Divalent Heavy Metal Cations Block the TRPV1 Ca²⁺ Channel
Published in Biological trace element research (01-03-2013)“…Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel involved in pain sensation and in a wide range of non-pain-related…”
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Divalent Heavy Metal Cations Block the TRPV1 Ca super(2+) Channel
Published in Biological trace element research (01-03-2013)“…Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel involved in pain sensation and in a wide range of non-pain-related…”
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Investigation of the Transient Receptor Potential Vanilloid 1 (TRPV1) Ion Channel
Published 01-01-2013“…The aims of this research were to determine sensory modalities that may be lost after the RTX treatment of newborn or adult mice, to dissect potential…”
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Dissertation