Search Results - "Winter, Laurie"

Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease by Southwell, Amber L, Franciosi, Sonia, Villanueva, Erika B, Xie, Yuanyun, Winter, Laurie A, Veeraraghavan, Janaki, Jonason, Alan, Felczak, Boguslaw, Zhang, Weining, Kovalik, Vlad, Waltl, Sabine, Hall, George, Pouladi, Mahmoud A, Smith, Ernest S, Bowers, William J, Zauderer, Maurice, Hayden, Michael R

“…Abstract Huntington disease (HD) is an inherited, fatal neurodegenerative disease with no disease-modifying therapy currently available. In addition to…”
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Safety, Pharmacokinetics, and Pharmacodynamics of a Humanized Anti-Semaphorin 4D Antibody, in a First-In-Human Study of Patients with Advanced Solid Tumors by Patnaik, Amita, Weiss, Glen J, Leonard, John E, Rasco, Drew Warren, Sachdev, Jasgit C, Fisher, Terrence L, Winter, Laurie A, Reilly, Christine, Parker, Robert B, Mutz, Danielle, Blaydorn, Lisa, Tolcher, Anthony W, Zauderer, Maurice, Ramanathan, Ramesh K

“…Study objectives included evaluating the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity of VX15/2503 in advanced…”
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Nonclinical Safety Evaluation of VX15/2503, a Humanized IgG4 Anti-SEMA4D Antibody by Leonard, John E, Fisher, Terrence L, Winter, Laurie A, Cornelius, Chad A, Reilly, Christine, Smith, Ernest S, Zauderer, Maurice

“…The humanized IgG4 monoclonal antibody VX15/2503 bound with 1 to 5 nmol/L affinity to purified recombinant semaphorin 4D (SEMA4D; CD100) produced using murine,…”
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Antibody Blockade of Semaphorin 4D Promotes Immune Infiltration into Tumor and Enhances Response to Other Immunomodulatory Therapies by Evans, Elizabeth E, Jonason, Jr, Alan S, Bussler, Holm, Torno, Sebold, Veeraraghavan, Janaki, Reilly, Christine, Doherty, Michael A, Seils, Jennifer, Winter, Laurie A, Mallow, Crystal, Kirk, Renee, Howell, Alan, Giralico, Susan, Scrivens, Maria, Klimatcheva, Katya, Fisher, Terrence L, Bowers, William J, Paris, Mark, Smith, Ernest S, Zauderer, Maurice

“…Semaphorin 4D (SEMA4D, CD100) and its receptor plexin-B1 (PLXNB1) are broadly expressed in murine and human tumors, and their expression has been shown to…”
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Safety/tolerability of the anti-semaphorin 4D antibody VX15/2503 in a randomized phase 1 trial by LaGanke, Christopher, Samkoff, Lawrence, Edwards, Keith, Jung Henson, Lily, Repovic, Pavle, Lynch, Sharon, Stone, Lael, Mattson, David, Galluzzi, Aaron, Fisher, Terrence L, Reilly, Christine, Winter, Laurie A, Leonard, John E, Zauderer, Maurice

“…OBJECTIVE:To evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of VX15/2503 in a randomized, single-dose, dose-escalation,…”
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Generation and preclinical characterization of an antibody specific for SEMA4D by Fisher, Terrence L, Reilly, Christine A, Winter, Laurie A, Pandina, Tracy, Jonason, Alan, Scrivens, Maria, Balch, Leslie, Bussler, Holm, Torno, Sebold, Seils, Jennifer, Mueller, Loretta, Huang, He, Klimatcheva, Ekaterina, Howell, Alan, Kirk, Renee, Evans, Elizabeth, Paris, Mark, Leonard, John E, Smith, Ernest S, Zauderer, Maurice

“…Semaphorin 4D (SEMA4D or CD100) is a member of the semaphorin family of proteins and an important mediator of the movement and differentiation of multiple cell…”
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Abstract 4888: Antibody blockade of semaphorin 4D breaks down stromal barriers to enhance tumoricidal immune infiltration, supporting rational immunotherapy combinations by Evans, Elizabeth E., Bussler, Holm, Torno, Sebold, Mallow, Crystal, Reilly, Christine, Scrivens, Maria, Klimatcheva, Ekaterina, Winter, Laurie A., Kirk, Renee, Howell, Alan, Balch, Leslie, Leonard, John E., Paris, Mark, Fisher, Terrence L., Hu-Lieskovan, Siwen, Ribas, Antoni, Smith, Ernest S., Zauderer, Maurice

“…Semaphorin 4D (SEMA4D, CD100) and its receptor plexin-B1 are broadly expressed in cancer; increased expression correlates with poor prognosis. SEMA4D normally…”
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An immunologic test for chronic rhinosinusitis based on free intranasal eosinophilic major basic protein by Ponikau, Jens U., Winter, Laurie A., Kephart, Gail M., Squillace, Diane L., Hershcovitch, Matt D., Moon, Seo, Sherris, David A., Kern, Eugene B., Gleich, Gerald J., Kita, Hirohito

“…Background A histologic hallmark of chronic rhinosinusitis (CRS) is an eosinophilic inflammation, present with and without nasal polyposis and independent of…”
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Structure of the Streptococcal Cell Wall C5a Peptidase by Brown, C. Kent, Zu-Yi Gu, Yury V. Matsuka, Sai S. Purushothaman, Laurie A. Winter, Cleary, P. Patrick, Stephen B. Olmsted, Douglas H. Ohlendorf, Cathleen A. Earhart, Matthews, Brian W.

“…The structure of a cell surface enzyme from a Gram-positive pathogen has been determined to 2-Å resolution. Gram-positive pathogens have a thick cell wall to…”
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The pro-sequence domain of streptopain directs the folding of the mature enzyme by Anderson, Elizabeth T., Winter, Laurie A., Fernsten, Phil, Olmsted, Stephen B., Matsuka, Yury V.

“…The cysteine endopeptidase streptopain, an extracellular enzyme from pathogenic Streptococcus pyogenes, is synthesized as a precursor containing an NH…”
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More than a Reading Intervention: Teachers Working Together to Improve the Reading Achievement of Students from Culturally and Linguistically Diverse Backgrounds by Nielsen, Diane Corcoran, Winter, Laurie Leiker, Keetle, Susan, Jackson, Clarissa

“…A diverse, Midwestern, high-poverty urban school district, under the guidance of a university reading professor with expertise in research-based instruction…”
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Processing, stability, and kinetic parameters of C5a peptidase from Streptococcus pyogenes by Anderson, Elizabeth T., Wetherell, Michael G., Winter, Laurie A., Olmsted, Stephen B., Cleary, Patrick P., Matsuka, Yury V.

“…A recombinant streptococcal C5a peptidase was expressed in Escherichia coli and its catalytic properties and thermal stability were subjected to examination…”
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Induction of HSV-gD2 specific CD4 + cells in Peyer's patches and mucosal antibody responses in mice following DNA immunization by both parenteral and mucosal administration by Shroff, Khushroo E, Marcucci-Borges, Lisa A, de Bruin, Sylvia J, Winter, Laurie A, Tiberio, Lorrie, Pachuk, Cathy, Snyder, Linda A, Satishchandran, C, Ciccarelli, Richard B, Higgins, Terry J

“…A DNA vaccine encoding glycoprotein D (gD) of herpes simplex virus type 2 (pHSV-gD2) was injected via parenteral and mucosal routes to determine the optimal…”
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Antibody blockade of semaphorin 4D promotes infiltration of activated tumor infiltrating leukocytes and inhibits tumor growth. (TUM7P.1030) by Klimatcheva, Ekaterina, Evans, Elizabeth, Bussler, Holm, Torno, Sebold, Mallow, Crystal, Winter, Laurie, Reilly, Christine, Veeraraghavan, Janaki, Jonason, Alan S., Scrivens, Maria, Kirk, Renee, Giralico, Susan, Howell, Alan, Leonard, John, Paris, Mark, Fisher, Terrence, Smith, Ernest, Zauderer, Maurice

“…Semaphorin 4D (SEMA4D, CD100) and its receptor plexin-B1 are broadly expressed in cancer and expression correlates with invasive disease. A novel function of…”
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Abstract 936: Nonclinical safety and pharmacology of VX15/2503: a humanized IgG4 monoclonal antibody to SEMA4D by Cornelius, Chad A., Fisher, Terrence, Seils, Jennifer, Winter, Laurie A., Jonason, Alan S., Smith, Ernest, Watkins, Raymond, Zauderer, Maurice, Leonard, John E.

“…Vaccinex is developing VX15/2503, a humanized IgG4 anti-Semaphorin 4D (SEMA4D; CD100) antibody with approximately 5 nM affinity, for the treatment of patients…”
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Abstract 4578: Nonclinical safety assessment of VX15/2503: A humanized IgG4 monoclonal antibody to sema4D by Cornelius, Chad A., Fisher, Terrence L., Winter, Laurie A., Seils, Jennifer, Reilly, Christine A., Jonason, Alan S., Smith, Ernest, Watkins, Raymond, Zauderer, Maurice, Leonard, John E.

“…VX15/2503 is a humanized IgG4 monoclonal antibody that binds with approximately 3 nM affinity to Semaphorin 4D (SEMA4D, CD100). SEMA4D is an important mediator…”
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Abstract 1245: Reduction of tumor growth and metastasis by a humanized IgG4 monoclonal antibody to SEMA4D (VX15/2503) by Evans, Elizabeth E., Jonason, Alan S., Paris, Mark, Fisher, Terrence L., Torno, Sebold, Bussler, Holm, Decker, Jessica, Scrivens, Maria, Huang, He, Winter, Laurie A., Pandina, Tracy, Balch, Leslie, Doherty, Michael A., Kirk, Renee, Howell, Alan, Seils, Jennifer, Reilly, Christine, Zauderer, Maurice, Leonard, John E., Smith, Ernest S.

“…Semaphorin 4D (SEMA4D; CD100) has been implicated in several key mechanisms of tumor progression, including transactivation of several oncogenes, metastasis,…”
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Abstract 2531: Reduction of In Vivo Tumor Growth and Angiogenesis by a Humanized IgG4 Monoclonal Antibody to SEMA4D by Jonason, Alan S., Fisher, Terrence L., Torno, Sebold, Bussler, Holm, Doherty, Michael A., Winter, Laurie A., Reilly, Christine, Kirk, Renee, Howell, Alan, Huang, He, Caplan, Jeff, Kenney, Patrick, Scrivens, Maria, Pandina, Tracy, Croy, Leslie, Evans, Elizabeth E., Paris, Mark, Watkins, Raymond, Zauderer, Maurice, Leonard, John E., Smith, Ernest S.

“…Semaphorin 4D (SEMA4D; CD100) has been implicated in several key mechanisms of tumor progression, including metastasis, tumor invasion, and neovascularization…”
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Abstract 3667: Reduction of in vivo tumor growth and angiogenesis by a humanized IgG4 monoclonal antibody to SEMA4D by Jonason, Alan S., Fisher, Terrence L., Torno, Sebold, Bussler, Holm, Winter, Laurie A., Kirk, Renee, Howell, Alan, Caplan, Jeff, Kenney, Patrick, Reilly, Christine, Scrivens, Maria, Huang, He, Croy, Leslie, Evans, Elizabeth E., Paris, Mark, Watkins, Raymond, Zauderer, Maurice, Leonard, John E., Smith, Ernest S.

“…Semaphorin 4D (SEMA4D; CD100) has been implicated in several key mechanisms of tumor progression, including neovascularization, tumor invasion, and metastasis…”
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Abstract LB-36: Antibody mediated neutralization of sema4D reduces tumor angiogenesis and growth In Vivo by Jonason, Alan, Fisher, Terrance, Torno, Sebold, Bussler, Holm, Li, Ji, Winter, Laurie, Kirk, Renee, Howell, Alan, Caplan, Jeff, Kenney, Patrick, Reilly, Christine, Scrivens, Maria, Evans, Elizabeth, Paris, Mark, Watkins, Raymond, Zauderer, Maurice, Leonard, John E., Smith, Ernest S.

“…It has been demonstrated that semaphorin 4D (SEMA4D; CD100) is a potent pro-angiogenic molecule. SEMA4D binding to its receptor plexin-B1 (PLXNB1) on…”
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