Search Results - "Winter, Christopher"

An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies by O'Neil, Jennifer, Benita, Yair, Feldman, Igor, Chenard, Melissa, Roberts, Brian, Liu, Yaping, Li, Jing, Kral, Astrid, Lejnine, Serguei, Loboda, Andrey, Arthur, William, Cristescu, Razvan, Haines, Brian B, Winter, Christopher, Zhang, Theresa, Bloecher, Andrew, Shumway, Stuart D

“…Combination drug therapy is a widely used paradigm for managing numerous human malignancies. In cancer treatment, additive and/or synergistic drug combinations…”
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Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition by Lampa, Michael, Arlt, Heike, He, Timothy, Ospina, Beatriz, Reeves, Jason, Zhang, Bailin, Murtie, Joshua, Deng, Gejing, Barberis, Claude, Hoffmann, Dietmar, Cheng, Hong, Pollard, Jack, Winter, Christopher, Richon, Victoria, Garcia-Escheverria, Carlos, Adrian, Francisco, Wiederschain, Dmitri, Srinivasan, Lakshmi

“…Tumor cells display fundamental changes in metabolism and nutrient uptake in order to utilize additional nutrient sources to meet their enhanced bioenergetic…”
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Full mass dependence in Higgs boson production in association with jets at the LHC and FCC by Greiner, Nicolas, Höche, Stefan, Luisoni, Gionata, Schönherr, Marek, Winter, Jan-Christopher

“…A bstract The first computation of Higgs production in association with three jets at NLO in QCD has recently been performed using the effective theory, where…”
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Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells by Sethi, Nilay, Dai, Xudong, Winter, Christopher G., Kang, Yibin

“…Despite evidence supporting an oncogenic role in breast cancer, the Notch pathway's contribution to metastasis remains unknown. Here, we report that the Notch…”
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Is there a fundamental flaw in Canada's post-arrival immigrant surveillance system for tuberculosis? by Long, Richard, Asadi, Leyla, Heffernan, Courtney, Barrie, James, Winter, Christopher, Egedahl, Mary Lou, Paulsen, Catherine, Kunimoto, Brenden, Menzies, Dick

“…New immigrants to Canada with a history of tuberculosis or evidence of old healed tuberculosis on chest radiograph are referred to public health authorities…”
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Combination of the mTOR inhibitor ridaforolimus and the anti-IGF1R monoclonal antibody dalotuzumab: preclinical characterization and phase I clinical trial by Di Cosimo, Serena, Sathyanarayanan, Sriram, Bendell, Johanna C, Cervantes, Andrés, Stein, Mark N, Braña, Irene, Roda, Desamparados, Haines, Brian B, Zhang, Theresa, Winter, Christopher G, Jha, Sharda, Xu, Youyuan, Frazier, Jason, Klinghoffer, Richard A, Leighton-Swayze, Ann, Song, Yang, Ebbinghaus, Scot, Baselga, José

“…Mammalian target of rapamycin (mTOR) inhibition activates compensatory insulin-like growth factor receptor (IGFR) signaling. We evaluated the ridaforolimus…”
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Phenomenological analysis of Higgs boson production through gluon fusion in association with jets by Greiner, Nicolas, Höche, Stefan, Luisoni, Gionata, Schönherr, Marek, Winter, Jan-Christopher, Yundin, Valery

“…A bstract We present a detailed phenomenological analysis of the production of a Standard Model Higgs boson in association with up to three jets. We consider…”
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A comparison of the chest radiographic and computed tomographic features of subclinical pulmonary tuberculosis by Lau, Angela, Lin, Christopher, Barrie, James, Winter, Christopher, Armstrong, Gavin, Egedahl, Mary Lou, Doroshenko, Alexander, Heffernan, Courtney, Asadi, Leyla, Fisher, Dina, Paulsen, Catherine, Moolji, Jalal, Huang, Yiming, Long, Richard

“…Subclinical pulmonary tuberculosis (PTB) is a recently described intermediate state of great interest, but about which little is known. This study sought to…”
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Chest Radiographic Patterns and the Transmission of Tuberculosis: Implications for Automated Systems by Lau, Angela, Barrie, James, Winter, Christopher, Elamy, Abdel-Halim, Tyrrell, Gregory, Long, Richard

“…Computer-aided detection to identify and diagnose pulmonary tuberculosis is being explored. While both cavitation on chest radiograph and smear-positivity on…”
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The prevalence, risk factors, and public health consequences of peripheral lymph node–associated clinical and subclinical pulmonary tuberculosis by Heffernan, Courtney, Egedahl, Mary Lou, Barrie, James, Winter, Christopher, Armstrong, Gavin, Doroshenko, Alexander, Tyrrell, Gregory, Paulsen, Catherine, Lau, Angela, Long, Richard

“…•Concurrent pulmonary tuberculosis (TB) is common in patients with peripheral lymph node TB.•Symptoms, radiographic findings, and HIV are risk factors for…”
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Pan-TGFβ inhibition by SAR439459 relieves immunosuppression and improves antitumor efficacy of PD-1 blockade by Greco, Rita, Qu, Hongjing, Qu, Hui, Theilhaber, Joachim, Shapiro, Gary, Gregory, Richard, Winter, Christopher, Malkova, Natalia, Sun, Frank, Jaworski, Julie, Best, Annie, Pao, Lily, Hebert, Andrew, Levit, Mikhail, Protopopov, Alexei, Pollard, Jack, Bahjat, Keith, Wiederschain, Dmitri, Sharma, Sharad

“…TGFβ is a pleiotropic cytokine that may have both tumor inhibiting and tumor promoting properties, depending on tissue and cellular context. Emerging data…”
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Identification of the endosomal sorting complex required for transport-I (ESCRT-I) as an important modulator of anti-miR uptake by cancer cells by Wagenaar, Timothy R, Tolstykh, Tatiana, Shi, Chaomei, Jiang, Lan, Zhang, JingXin, Li, Zhifang, Yu, Qunyan, Qu, Hui, Sun, Fangxian, Cao, Hui, Pollard, Jack, Dai, Shujia, Gao, Qiang, Zhang, Bailin, Arlt, Heike, Cindhuchao, May, Hoffmann, Dietmar, Light, Madelyn, Jensen, Karin, Hopke, Joern, Newcombe, Richard, Garcia-Echeverria, Carlos, Winter, Christopher, Zabludoff, Sonya, Wiederschain, Dmitri

“…Mechanisms of unassisted delivery of RNA therapeutics, including inhibitors of microRNAs, remain poorly understood. We observed that the hepatocellular…”
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Inhibition of NOTCH Signaling by Gamma Secretase Inhibitor Engages the RB Pathway and Elicits Cell Cycle Exit in T-Cell Acute Lymphoblastic Leukemia Cells by RAO, Sudhir S, O'NEIL, Jennifer, VAN DER PLOEG, Lex H. T, CARROLL, Pamela M, DRAETTA, Giulio F, LOOK, A. Thomas, STACK, Peter R, WINTER, Christopher G, LIBERATOR, Cole D, HARDWICK, James S, XUDONG DAI, ZHANG, Theresa, TYMINSKI, Edyta, JING YUAN, KOHL, Nancy E, RICHON, Victoria M

“…NOTCH signaling is deregulated in the majority of T-cell acute lymphoblastic leukemias (T-ALL) as a result of activating mutations in NOTCH1. Gamma secretase…”
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Deep inspirational breast hold (DIBH) for right breast irradiation: Improved sparing of liver and lung tissue by Mader, Thomas, Pace, Rachel, Boucas da Silva, Rui T., Erwin Johannes Adam, Lukas, Näf, Gabriela, Charles Winter, Christopher, Maria Aspradakis, Mania, Radovic, Marco, Spyridonidis, Aristotelis, Hayoz, Stefanie, Gertrud Baumert, Brigitta

“…•Deep inspirational breast hold for right breast cancer reduces dose to liver and lung significantly.•Decrease in side effects and long-term toxicity for…”
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Prescribing Trends and Associated Outcomes of Antiepileptic Drugs and Other Psychotropic Medications in US Nursing Homes: Proposal for a Mixed Methods Investigation by Winter, Jonathan D, Kerns, J William, Brandt, Nicole, Wastila, Linda, Qato, Danya, Sabo, Roy T, Petterson, Stephen, Chung, YoonKyung, Reves, Sarah, Winter, Christopher, Winter, Katherine M, Elonge, Eposi, Ewasiuk, Craig, Fu, Yu-Hua, Funk, Adam, Krist, Alex, Etz, Rebecca

“…Pilot data suggest that off-label, unmonitored antiepileptic drug prescribing for behavioral and psychological symptoms of dementia is increasing, replacing…”
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Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia by Sanda, Takaomi, Li, Xiaoyu, Gutierrez, Alejandro, Ahn, Yebin, Neuberg, Donna S., O'Neil, Jennifer, Strack, Peter R., Winter, Christopher G., Winter, Stuart S., Larson, Richard S., von Boehmer, Harald, Look, A. Thomas

“…To identify dysregulated pathways in distinct phases of NOTCH1-mediated T-cell leukemogenesis, as well as small-molecule inhibitors that could synergize with…”
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Limitations of Chest Radiography in Diagnosing Subclinical Pulmonary Tuberculosis in Canada by Long, Richard, Lau, Angela, Barrie, James, Winter, Christopher, Armstrong, Gavin, Egedahl, Mary Lou, Doroshenko, Alexander

“…Subclinical pulmonary tuberculosis (PTB) is defined as “…a state of disease due to viable Mycobacterium tuberculosis that does not cause TB-related symptoms…”
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Model-independent production of a top-philic resonance at the LHC by Greiner, Nicolas, Kong, Kyoungchul, Park, Jong-Chul, Park, Seong Chan, Winter, Jan-Christopher

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Drosophila Rho-Associated Kinase (Drok) Links Frizzled-Mediated Planar Cell Polarity Signaling to the Actin Cytoskeleton by Winter, Christopher G., Wang, Bruce, Ballew, Anna, Royou, Anne, Karess, Roger, Axelrod, Jeffrey D., Luo, Liqun

“…Frizzled (Fz) and Dishevelled (Dsh) are components of an evolutionarily conserved signaling pathway that regulates planar cell polarity. How this signaling…”
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Measuring circadian advantage in Major League Baseball: a 10-year retrospective study by Winter, W Christopher, Hammond, William R, Green, Noah H, Zhang, Zhiyong, Bliwise, Donald L

“…The effect of travel on athletic performance has been investigated in previous studies. The purpose of this study was to investigate this effect on game…”
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