Search Results - "Winter, Christa"

Cross-sectional study into age-related pathology of mouse models for limb girdle muscular dystrophy types 2D and 2F by Verhaart, Ingrid E C, Putker, Kayleigh, van de Vijver, Davy, Tanganyika-de Winter, Christa L, Pasteuning-Vuhman, Svetlana, Plomp, Jaap J, Aartsma-Rus, Annemieke M, van Putten, Maaike

“…Limb girdle muscular dystrophy (LGMD) types 2D and 2F are caused by mutations in the genes encoding for α- and δ-sarcoglycan, respectively, leading to…”
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Voluntary exercise improves muscle function and does not exacerbate muscle and heart pathology in aged Duchenne muscular dystrophy mice by Kogelman, Bauke, Putker, Kayleigh, Hulsker, Margriet, Tanganyika-de Winter, Christa, van der Weerd, Louise, Aartsma-Rus, Annemieke, van Putten, Maaike

“…Duchenne muscular dystrophy is a severe muscle wasting disease, characterized by a severely reduced lifespan in which cardiomyopathy is one of the leading…”
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Cyclic Peptides to Improve Delivery and Exon Skipping of Antisense Oligonucleotides in a Mouse Model for Duchenne Muscular Dystrophy by Jirka, Silvana M.G., ’t Hoen, Peter A.C., Diaz Parillas, Valeriano, Tanganyika-de Winter, Christa L., Verheul, Ruurd C., Aguilera, Begona, de Visser, Peter C., Aartsma-Rus, Annemieke M.

“…Duchenne muscular dystrophy (DMD) is a severe, progressive muscle wasting disorder caused by reading frame disrupting mutations in the DMD gene. Exon skipping…”
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In vivo comparison of 2′-O-methyl phosphorothioate and morpholino antisense oligonucleotides for Duchenne muscular dystrophy exon skipping by Heemskerk, Hans A., de Winter, Christa L., de Kimpe, Sjef J., van Kuik-Romeijn, Petra, Heuvelmans, Niki, Platenburg, Gerard J., van Ommen, Gert-Jan B., van Deutekom, Judith C. T., Aartsma-Rus, Annemieke

“…Background Antisense‐mediated exon skipping is a putative treatment for Duchenne muscular dystrophy (DMD). Using antisense oligonucleotides (AONs), the…”
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Music alters heart rate and psychological responses but not muscle activation during light-intensity isometric exercise by Moore, Andrew R., Hutchinson, Jasmin C., Winter, Christa, Dalton, Paul C., Bolgla, Lori A., Paolone, Vincent J.

“…Listening to music manipulates attention to be more externally focused, which has the potential to improve muscular efficiency. This study aimed to determine…”
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Guidelines for Antisense Oligonucleotide Design and Insight Into Splice-modulating Mechanisms by Aartsma-Rus, Annemieke, van Vliet, Laura, Hirschi, Marscha, Janson, Anneke AM, Heemskerk, Hans, de Winter, Christa L, de Kimpe, Sjef, van Deutekom, Judith CT, 't Hoen, Peter AC, van Ommen, Gert-Jan B

“…Antisense oligonucleotides (AONs) can interfere with mRNA processing through RNase H–mediated degradation, translational arrest, or modulation of splicing. The…”
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Assessment of the feasibility of exon 45-55 multiexon skipping for Duchenne muscular dystrophy by van Vliet, Laura, de Winter, Christa L, van Deutekom, Judith C T, van Ommen, Gert-Jan B, Aartsma-Rus, Annemieke

“…The specific skipping of an exon, induced by antisense oligonucleotides (AON) during splicing, has shown to be a promising therapeutic approach for Duchenne…”
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Peptide conjugation of 2'-O-methyl phosphorothioate antisense oligonucleotides enhances cardiac uptake and exon skipping in mdx mice by Jirka, Silvana M G, Heemskerk, Hans, Tanganyika-de Winter, Christa L, Muilwijk, Daan, Pang, Kar Him, de Visser, Peter C, Janson, Anneke, Karnaoukh, Tatyana G, Vermue, Rick, 't Hoen, Peter A C, van Deutekom, Judith C T, Aguilera, Begoña, Aartsma-Rus, Annemieke

“…Antisense oligonucleotide (AON)-mediated exon skipping is a promising therapeutic approach for Duchenne muscular dystrophy that is currently being tested in…”
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Comparing the Changes in Blood Pressure After Acute Exposure to Tai Chi and Walking by Maris, Stephen A, Winter, Christa R, Paolone, Vincent J, Headley, Samuel A E

“…Hypertension is a major health concern throughout the United States and is a major cause of cardiovascular disease. The purpose of this study was to compare…”
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The Effects of Mental Imagery with Video-Modeling on Self-Efficacy and Maximal Front Squat Ability by Buck, Daniel J M, Hutchinson, Jasmin C, Winter, Christa R, Thompson, Brian A

“…This study was designed to assess the effectiveness of mental imagery supplemented with video-modeling on self-efficacy and front squat strength (three…”
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Evaluation of 2’-Deoxy-2’-fluoro Antisense Oligonucleotides for Exon Skipping in Duchenne Muscular Dystrophy by Jirka, Silvana M G, Tanganyika-de Winter, Christa L, Boertje-van der Meulen, Joke W, van Putten, Maaike, Hiller, Monika, Vermue, Rick, de Visser, Peter C, Aartsma-Rus, Annemieke

“…Duchenne muscular dystrophy (DMD) is a severe muscle wasting disorder typically caused by frame-shifting mutations in the DMD gene. Restoration of the reading…”
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Long-term Exon Skipping Studies With 2′-O-Methyl Phosphorothioate Antisense Oligonucleotides in Dystrophic Mouse Models by Tanganyika-de Winter, Christa L, Heemskerk, Hans, Karnaoukh, Tatyana G, van Putten, Maaike, de Kimpe, Sjef J, van Deutekom, Judith, Aartsma-Rus, Annemieke

“…Antisense-mediated exon skipping for Duchenne muscular dystrophy (DMD) is currently tested in phase 3 clinical trials. The aim of this approach is to modulate…”
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Development of Antisense-Mediated Exon Skipping as a Treatment for Duchenne Muscular Dystrophy by Heemskerk, Hans, de Winter, Christa L., van Ommen, Gert-Jan B., van Deutekom, Judith C.T., Aartsma-Rus, Annemieke

“…Duchenne muscular dystrophy (DMD) is a severe muscle‐wasting disease caused by frame shifting and nonsense mutations in the dystrophin gene. Through skipping…”
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Comparative analysis of antisense oligonucleotide sequences targeting exon 53 of the human DMD gene: Implications for future clinical trials by Popplewell, Linda J, Adkin, Carl, Arechavala-Gomeza, Virginia, Aartsma-Rus, Annemieke, de Winter, Christa L, Wilton, Steve D, Morgan, Jennifer E, Muntoni, Francesco, Graham, Ian R, Dickson, George

“…Abstract Duchenne muscular dystrophy (DMD) is caused by the lack of functional dystrophin protein, most commonly as a result of a range of out-of-frame…”
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Preclinical PK and PD Studies on 2′-O-Methyl-phosphorothioate RNA Antisense Oligonucleotides in the mdx Mouse Model by Heemskerk, Hans, de Winter, Christa, van Kuik, Petra, Heuvelmans, Niki, Sabatelli, Patrizia, Rimessi, Paola, Braghetta, Paola, van Ommen, Gert-Jan B, de Kimpe, Sjef, Ferlini, Alessandra, Aartsma-Rus, Annemieke, van Deutekom, Judith CT

“…Antisense oligonucleotides (AONs) are being developed as RNA therapeutic molecules for Duchenne muscular dystrophy. For oligonucleotides with the…”
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Dose-dependent pharmacokinetic profiles of 2'-O-methyl phosphorothioate antisense oligonucleotidesin mdx mice by Verhaart, Ingrid E C, Tanganyika-de Winter, Christa L, Karnaoukh, Tatyana G, Kolfschoten, Ingrid G M, de Kimpe, Sjef J, van Deutekom, Judith C T, Aartsma-Rus, Annemieke

“…Antisense-mediated exon skipping is a promising therapeutic approach for Duchenne muscular dystrophy. It aims to restore the dystrophin open reading frame by…”
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Effects of physioball and conventional floor exercises on early phase adaptations in back and abdominal core stability and balance in women by Cosio-Lima, Ludmila M, Reynolds, Katy L, Winter, Christa, Paolone, Vincent, Jones, Margaret T

“…The purpose of this study was to compare the effects of 5 weeks of physioball core stability and balance exercises with conventional floor exercises in women…”
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Dystrophin deficiency leads to dysfunctional glutamate clearance in iPSC derived astrocytes by Patel, Abdulsamie M., Wierda, Keimpe, Thorrez, Lieven, van Putten, Maaike, De Smedt, Jonathan, Ribeiro, Luis, Tricot, Tine, Gajjar, Madhavsai, Duelen, Robin, Van Damme, Philip, De Waele, Liesbeth, Goemans, Nathalie, Tanganyika-de Winter, Christa, Costamagna, Domiziana, Aartsma-Rus, Annemieke, van Duyvenvoorde, Hermine, Sampaolesi, Maurilio, Buyse, Gunnar M., Verfaillie, Catherine M.

“…Duchenne muscular dystrophy (DMD) results, beside muscle degeneration in cognitive defects. As neuronal function is supported by astrocytes, which express…”
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Effects of Acute Resistance Exercise on Heart Rate Variability and Central Blood Pressure in Women: 1217 Board #25 May 31 8: 00 AM - 9: 30 AM by Dempsey, Kristen, Thompson, Brian, Winter, Christa, O’Neill, Elizabeth, Headley, Samuel

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Heart Rate Responses in the Diving Reflex among Aerobically Trained and Untrained Men: 2615 Board #5 June 1 3 15 PM - 5 15 PM by Lewis, Kathryn, Headley, Samuel, Peacock, Jessica, Winter, Christa, Paolone, Vincent

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