Search Results - "Winston, J. H"
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Neurological and cellular regulation of visceral hypersensitivity induced by chronic stress and colonic inflammation in rats
Published in Neuroscience (17-09-2013)“…Highlights • Novel findings on visceral hypersensitivity, inflammation and stress. • Chronic stress exacerbates hypersensitivity in the presence of…”
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Role of brain‐derived neurotrophic factor in the pathogenesis of distention‐associated abdominal pain in bowel obstruction
Published in Neurogastroenterology and motility (01-10-2018)“…Background Previous studies found that visceral sensitivity is increased in bowel obstruction (BO). We hypothesized that mechanical stress‐induced expression…”
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The Proteinase-Activated Receptor 2 Is Involved in Nociception
Published in The Journal of neuroscience (15-11-2001)“…The proteinase-activated receptor 2 is expressed on a subset of primary afferent neurons and may participate in the neurogenic component of inflammation. We…”
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P2X receptor-mediated visceral hyperalgesia in a rat model of chronic visceral hypersensitivity
Published in Gut (01-09-2008)“…Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterised by abdominal pain and bloating in association with altered bowel movements…”
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Neonatal immune challenge followed by adult immune challenge induces epigenetic‐susceptibility to aggravated visceral hypersensitivity
Published in Neurogastroenterology and motility (01-09-2017)“…Background Abdominal pain is one of the major symptoms of inflammatory Bowel Disease (IBD). The inflammatory mediators released by colon inflammation are known…”
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Chronic prenatal stress epigenetically modifies spinal cord BDNF expression to induce sex‐specific visceral hypersensitivity in offspring
Published in Neurogastroenterology and motility (01-05-2014)“…Background Irritable bowel syndrome (IBS) is a heterogeneous disorder with abdominal pain as one of the primary symptoms. The etiology of IBS remains unknown…”
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Auricular vagal nerve stimulation ameliorates burn‐induced gastric dysmotility via sympathetic‐COX‐2 pathways in rats
Published in Neurogastroenterology and motility (01-01-2016)“…Background Severe burn injury has been demonstrated to delay gastric emptying. The aim of this study was to investigate effects and cellular mechanisms of…”
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Electroacupuncture attenuates visceral hyperalgesia and inhibits the enhanced excitability of colon specific sensory neurons in a rat model of irritable bowel syndrome
Published in Neurogastroenterology and motility (01-12-2009)“…The causes of irritable bowel syndrome remain elusive and there are few effective treatments for pain in this syndrome. Electroacupunture (EA) is used…”
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Ameliorating effects of mirtazapine on visceral hypersensitivity in rats with neonatal colon sensitivity
Published in Neurogastroenterology and motility (01-09-2010)“…Background The aim was to investigate the effects of mirtazapine on visceral hypersensitivity and gastric emptying in an established rodent model of colonic…”
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5' flanking sequences of the murine adenosine deaminase gene direct expression of a reporter gene to specific prenatal and postnatal tissues in transgenic mice
Published in The Journal of biological chemistry (05-07-1992)“…Adenosine deaminase (ADA), an enzyme of purine metabolism, is highly expressed in four tissues of the mouse: the maternal decidua, the fetal placenta, the…”
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Trypsin mediates nociception via the proteinase-activated receptor 2: A potentially novel role in pancreatic pain
Published in Gastroenterology (New York, N.Y. 1943) (01-09-2004)“…Background & Aims: The pathogenesis of pain in pancreatitis remains poorly understood. We hypothesized that trypsin, a key inflammatory mediator in this…”
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Diverse Genetic Regulatory Motifs Required for Murine Adenosine Deaminase Gene Expression in the Placenta
Published in The Journal of biological chemistry (24-01-1997)“…Murine adenosine deaminase (ADA) is a ubiquitous purine catabolic enzyme whose expression is subject to developmental and tissue-specific regulation. ADA is…”
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Rat trehalase: cDNA cloning and mRNA expression in adult rat tissues and during intestinal ontogeny
Published in The American journal of physiology (01-05-1998)“…A partial rat trehalase cDNA has been cloned and used to examine trehalase mRNA expression. Northern blotting with total RNA from 11 adult rat tissues showed a…”
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Regulation of Forestomach-specific Expression of the Murine Adenosine Deaminase Gene
Published in The Journal of biological chemistry (09-04-1999)“…The maturation of stratified squamous epithelium of the upper gastrointestinal tract is a highly ordered process of development and differentiation…”
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Malignant islet cell adenoma in a pancreatic cyst. Report of a case
Published in Journal of the National Medical Association (01-05-1965)Get full text
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