Search Results - "Winstanley, Catharine"

The utility of rat models of impulsivity in developing pharmacotherapies for impulse control disorders by Winstanley, Catharine A

“…High levels of impulsive behaviours are a clinically significant symptom in a range of psychiatric disorders, such as attention deficit hyperactivity disorder,…”
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Deciphering Decision Making: Variation in Animal Models of Effort- and Uncertainty-Based Choice Reveals Distinct Neural Circuitries Underlying Core Cognitive Processes by Winstanley, Catharine A, Floresco, Stan B

“…Maladaptive decision-making is increasingly recognized to play a significant role in numerous psychiatric disorders, such that therapeutics capable of…”
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Dopamine antagonism decreases willingness to expend physical, but not cognitive, effort: a comparison of two rodent cost/benefit decision-making tasks by Hosking, Jay G, Floresco, Stan B, Winstanley, Catharine A

“…Successful decision making often requires weighing a given option's costs against its associated benefits, an ability that appears perturbed in virtually every…”
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Serotonergic and Dopaminergic Modulation of Gambling Behavior as Assessed Using a Novel Rat Gambling Task by ZEEB, Fiona D, ROBBINS, Trevor W, WINSTANLEY, Catharine A

“…Pathological gambling (PG) is characterized by persistent, maladaptive gambling behavior, which disrupts personal and professional life. Animal models of…”
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Functional disconnection of the orbitofrontal cortex and basolateral amygdala impairs acquisition of a rat gambling task and disrupts animals' ability to alter decision-making behavior after reinforcer devaluation by Zeeb, Fiona D, Winstanley, Catharine A

“…An inability to adjust choice preferences in response to changes in reward value may underlie key symptoms of many psychiatric disorders, including chemical…”
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Dopamine D3 Receptors Modulate the Ability of Win-Paired Cues to Increase Risky Choice in a Rat Gambling Task by Barrus, Michael M, Winstanley, Catharine A

“…Similar to other addiction disorders, the cues inherent in many gambling procedures are thought to play an important role in mediating their addictive nature…”
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Lesions of the basolateral amygdala and orbitofrontal cortex differentially affect acquisition and performance of a rodent gambling task by Zeeb, Fiona D, Winstanley, Catharine A

“…Risky decision making on the Iowa Gambling Task (IGT) has been observed in several psychiatric disorders, including substance abuse, schizophrenia, and…”
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Behavioral models of impulsivity in relation to ADHD: Translation between clinical and preclinical studies by Winstanley, Catharine A., Eagle, Dawn M., Robbins, Trevor W.

“…Impulsivity, broadly defined as action without foresight, is a component of numerous psychiatric illnesses including attention deficit/hyperactivity disorder…”
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The Orbitofrontal Cortex, Impulsivity, and Addiction by WINSTANLEY, CATHARINE A.

“…:  The association between impulsivity and addiction is currently a topic of intense research interest. Investigations into the neurobiological basis of…”
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Dissociable Contributions of Anterior Cingulate Cortex and Basolateral Amygdala on a Rodent Cost/Benefit Decision-Making Task of Cognitive Effort by HOSKING, Jay G, COCKER, Paul J, WINSTANLEY, Catharine A

“…Personal success often requires the choice to expend greater effort for larger rewards, and deficits in such effortful decision making accompany a number of…”
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Decreased risk‐taking and loss‐chasing after subthalamic nucleus lesion in rats by Breysse, Emmanuel, Meffre, Julie, Pelloux, Yann, Winstanley, Catharine A., Baunez, Christelle

“…The subthalamic nucleus (STN) is known to play a role in the control of impulsivity of action and in impulsivity of choice under certain conditions. In order…”
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The orbitofrontal cortex, impulsivity, and addiction: probing orbitofrontal dysfunction at the neural, neurochemical, and molecular level by Winstanley, Catharine A

“…The association between impulsivity and addiction is currently a topic of intense research interest. Investigations into the neurobiological basis of aspects…”
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Noradrenergic contributions to cue-driven risk-taking and impulsivity by Chernoff, Chloe S., Hynes, Tristan J., Winstanley, Catharine A.

“…Rationale The flashing lights and sounds of modern casinos are alluring and may contribute to the addictive nature of gambling. Such cues can have a profound…”
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Insight into differing decision-making strategies that underlie cognitively effort-based decision making using computational modeling in rats by Hales, Claire A., Silveira, Mason M., Calderhead, Lucas, Mortazavi, Leili, Hathaway, Brett A., Winstanley, Catharine A.

“…Rationale The rat cognitive effort task (rCET), a rodent model of cognitive rather than physical effort, requires animals to choose between an easy or hard…”
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Increased risky choice during forced abstinence from fentanyl on the cued rat gambling task by Hrelja, Kelly M, Kawkab, Carol, Avramidis, Dimitrios K, Ramaiah, Shrishti, Winstanley, Catharine A

“…The use of illicit opioids has arguably never been more risky; street drug potency can be dangerously high, is often unknown to the consumer, and results in…”
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Kindling of the basolateral or central nucleus of the amygdala increases suboptimal choice in a rat gambling task and increases motor impulsivity in risk-preferring animals by Tremblay, Melanie, Adams, Wendy K., Winstanley, Catharine A.

“…Impairments in decision making under uncertainty, as measured by the Iowa Gambling Task (IGT), are observed in persons suffering from temporal lobe epilepsy…”
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Pathological choice: the neuroscience of gambling and gambling addiction by Clark, Luke, Averbeck, Bruno, Payer, Doris, Sescousse, Guillaume, Winstanley, Catharine A, Xue, Gui

“…Gambling is pertinent to neuroscience research for at least two reasons. First, gambling is a naturalistic and pervasive example of risky decision making, and…”
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Pharmacological evidence of a cholinergic contribution to elevated impulsivity and risky decision-making caused by adding win-paired cues to a rat gambling task by Betts, Graeme D, Hynes, Tristan J, Winstanley, Catharine A

“…Background: Pairing rewards with sensory stimulation, in the form of auditory and visual cues, increases risky decision-making in both rats and humans…”
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Risk taking and impulsive behaviour: fundamental discoveries, theoretical perspectives and clinical implications by Isles, Anthony R., Winstanley, Catharine A., Humby, Trevor

“…Our willingness to take risks, our ability to wait or the speed with which to make decisions are central features of our personality. However, it is now…”
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Contributions of the orbitofrontal cortex to impulsive choice: interactions with basal levels of impulsivity, dopamine signalling, and reward-related cues by Zeeb, Fiona D., Floresco, Stan B., Winstanley, Catharine A.

“…Rationale Individual differences in impulsive decision-making may be critical determinants of vulnerability to impulse control disorders and substance abuse,…”
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