Search Results - "Winssinger, N."

In cellulo protein labelling with Ru-conjugate for luminescence imaging and bioorthogonal photocatalysis by Sadhu, Kalyan K, Lindberg, E, Winssinger, N

“…Labelling of proteins with a luminescent ruthenium complex enables the direct visualization and photocatalytic reduction of aryl azide in live cells. The…”
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DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules by Daguer, J-P, Zambaldo, C, Ciobanu, M, Morieux, P, Barluenga, S, Winssinger, N

“…Fragment-based lead discovery has proven to be a powerful method in the drug discovery process. The combinatorial output that is accessible by combining…”
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Kinase-templated abiotic reaction by Saarbach, J, Lindberg, E, Folliet, S, Georgeon, S, Hantschel, O, Winssinger, N

“…Protein kinases are quintessential regulators of cellular function. Numerous pathologies are intimately linked to the dysregulated activity of a particular…”
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OC-0247: The novel HSP90 inhibitor NW457 sensitizes colorectal cancer cells for an immunogenic form cell death by Ernst, A, Winssinger, N, Belka, C, Lauber, K

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Duplex formation and secondary structure of γ-PNA observed by NMR and CD by Viéville, J.M.P., Barluenga, S., Winssinger, N., Delsuc, M.A.

“…Peptide nucleic acids (PNAs) are non-natural oligonucleotides mimics, wherein the phosphoribose backbone has been replaced by a peptidic moiety…”
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Synthesis of epothilones A and B in solid and solution phase by Nicolaou, K. C, Winssinger, N, Pastor, J, Ninkovic, S, Sarabia, F, He, Y, Vourloumis, D, Yang, Z, Li, T, Giannakakou, P, Hamel, E

“…Epothilones A and B, two compounds that have been recently isolated from myxobacterium Sorangium cellulosum strain 90, have generated intense interest among…”
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OC-0619: Targeting HSP90 with the small-molecule inhibitor NW457 sensitizes human glioblastoma cells to ionizing radiation by Albrecht, V, Orth, M, Kinzel, L, Seidl, K, Winssinger, N, Friedl, A, Belka, C, Lauber, K

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PD-0428: Targeting HSP90 with the novel inhibitor NW457 attenuates radioresistance of human glioblastoma cells by Kinzel, L, Seidl, K, Winssinger, N, Friedl, A.A, Belka, C, Lauber, K

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Solid and Solution Phase Synthesis and Biological Evaluation of Combinatorial Sarcodictyin Libraries by Nicolaou, K. C, Winssinger, N, Vourloumis, D, Ohshima, T, Kim, S, Pfefferkorn, J, Xu, J.-Y, Li, T

“…Isolated from certain species of soft corals, the sarcodictyins, eleutherobin, and eleuthosides have become important synthetic targets due the their novel…”
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Solid Phase Synthesis of Macrocycles by an Intramolecular Ketophosphonate Reaction. Synthesis of a (dl)-Muscone Library by Nicolaou, K. C, Pastor, Joaquín, Winssinger, Nicolas, Murphy, Fiona

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Cysteine Mapping in Conformationally Distinct Kinase Nucleotide Binding Sites: Application to the Design of Selective Covalent Inhibitors by Leproult, Emeline, Barluenga, Sofia, Moras, Dino, Wurtz, Jean-Marie, Winssinger, Nicolas

“…Kinases have emerged as one of the most prolific therapeutic targets. An important criterion in the therapeutic success of inhibitors targeting the nucleotide…”
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The Art and Science of Organic and Natural Products Synthesis by Nicolaou, K. C, Sorensen, E. J, Winssinger, N

“…In this article, the history of the art and science of organic and natural products synthesis is briefly reviewed and the state of the art is discussed. The…”
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Sars-CoV2- infection as a trigger of humoral response against apolipoprotein A-1 by Pagano, S, Yerly, S, Suh, N, Le Terrier, C, Farrera-Soler, L, Piumatti, G, Eberhardt, C S, Siegrist, C A, Eckerle, I, Stringhini, S, Guessous, I, Kaiser, L, Pugin, J, Winssinger, N, Vuilleumier, N

“…Abstract Background Unravelling autoimmune targets triggered by SARS-CoV-2 infection may provide crucial insights in the physiopathology of the disease and…”
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The molecular chaperone Hsp90α is required for meiotic progression of spermatocytes beyond pachytene in the mouse by Grad, Iwona, Cederroth, Christopher R, Walicki, Joël, Grey, Corinne, Barluenga, Sofia, Winssinger, Nicolas, De Massy, Bernard, Nef, Serge, Picard, Didier

“…The molecular chaperone Hsp90 has been found to be essential for viability in all tested eukaryotes, from the budding yeast to Drosophila. In mammals, two…”
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Kinase-templated abiotic reactionElectronic supplementary information (ESI) available. See DOI: 10.1039/c7sc01416c by Saarbach, J, Lindberg, E, Folliet, S, Georgeon, S, Hantschel, O, Winssinger, N

“…Protein kinases are quintessential regulators of cellular function. Numerous pathologies are intimately linked to the dysregulated activity of a particular…”
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Kinase-templated abiotic reaction† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc01416c Click here for additional data file by Saarbach, J., Lindberg, E., Folliet, S., Georgeon, S., Hantschel, O., Winssinger, N.

“…Protein kinases are quintessential regulators of cellular function. Protein kinases are quintessential regulators of cellular function. Numerous pathologies…”
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SARS-COV2- infection as a trigger of humoral response against apolipoprotein A-1 by Pagano, S., Yery, S., Meyer, B., Juillard, C., Suh, N., Le Terrier, C., Daguer, J.-P., Lluc, F.-S., Barluenga, S., Piumatti, G., Hartley, O., Lemaitre, B., Eberhardt, C.S., Siegrist, C.-A., Eckerle, I., Stringhini, S., Guessous, I., Kaiser, L., Pugin, J., Winssinger, N., Vuilleumier, N.

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Design, Synthesis, and Biological Evaluation of HSP90 Inhibitors Based on Conformational Analysis of Radicicol and Its Analogues by Moulin, Emilie, Zoete, Vincent, Barluenga, Sofia, Karplus, Martin, Winssinger, Nicolas

“…The molecular chaperone HSP90 is an attractive target for chemotherapy because its activity is required for the functional maturation of a number of oncogenes…”
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PNA-encoded synthesis (PES) of a 10 000-member heteroglycoconjugate library and microarray analysis of diverse lectins by Novoa, A., Machida, T., Barluenga, S., Imberty, A., Winssinger, N.

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Chemistry, Biology, and Medicine of the Glycopeptide Antibiotics by Nicolaou, K. C., Boddy, Christopher N. C., Bräse, Stefan, Winssinger, Nicolas

“…The war against infectious bacteria is not over! Although vancomycin and glycopeptide antibiotics have provided a strong last line of defence against many…”
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