Search Results - "Winslow, Robert M."

Oxygen: the poison is in the dose by Winslow, Robert M.

“…Cell‐free hemoglobin (Hb) has been blamed for a spectrum of problems, including vasoconstriction pancreatitis, myocardial infarction, and pulmonary…”
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A multicenter clinical study of the safety and activity of maleimide-polyethylene glycol-modified hemoglobin (hemospan®) in patients undergoing major orthopedic surgery by OLOFSSON, Christina, AHL, Torbjorn, WINSLOW, Robert M, JOHANSSON, Torsten, LARSSON, Sune, NELLGARD, Per, PONZER, Sari, FAGRELL, Bengt, PRZYBELSKI, Robert, KEIPERT, Peter, WINSLOW, Nancy

“…Hemospan (Sangart Inc., San Diego, CA), a polyethylene glycol-modified hemoglobin with unique oxygen transport properties, has successfully completed a phase I…”
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Solution Structure of Poly(ethylene) Glycol-Conjugated Hemoglobin Revealed by Small-Angle X-Ray Scattering: Implications for a New Oxygen Therapeutic by Svergun, Dmitri I., Ekström, Fredrik, Vandegriff, Kim D., Malavalli, Ashok, Baker, Dale A., Nilsson, Calle, Winslow, Robert M.

“…Developing protein therapeutics has posed challenges due to short circulating times and toxicities. Recent advances using poly(ethylene) glycol (PEG)…”
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MP4, a new nonvasoactive PEG-Hb conjugate by Vandegriff, Kim D., Malavalli, Ashok, Wooldridge, Jerod, Lohman, Jeff, Winslow, Robert M.

“…BACKGROUND: Vasoconstriction has been an obstacle to clinical development of Hb‐based O2 carriers. It is proposed that this limitation can be overcome by…”
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Oxidation and haem loss kinetics of poly(ethylene glycol)-conjugated haemoglobin (MP4): dissociation between in vitro and in vivo oxidation rates by Vandegriff, Kim D, Malavalli, Ashok, Minn, Charles, Jiang, Eva, Lohman, Jeff, Young, Mark A, Samaja, Michele, Winslow, Robert M

“…Haemoglobin-based oxygen carriers can undergo oxidation of ferrous haemoglobin into a non-functional ferric form with enhanced rates of haem loss. A recently…”
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Toxicity and hemodynamic effects after single dose administration of MalPEG-hemoglobin (MP4) in rhesus monkeys by Young, Mark A, Malavalli, Ashok, Winslow, Nancy, Vandegriff, Kim D, Winslow, Robert M

“…Maleimide-polyethylene glycol-modified (MalPEG) hemoglobin, 4.3 g/dL (MP4; Hemospan), is a hemoglobin-based oxygen carrier consisting of human hemoglobin (Hb)…”
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Heme Oxygenase-1-Derived Carbon Monoxide Contributes to the Suppression of Acute Hypertensive Responses In Vivo by Motterlini, Roberto, Gonzales, Armando, Foresti, Roberta, Clark, James E, Green, Colin J, Winslow, Robert M

“…The enzyme heme oxygenase, which exists in inducible (HO-1) and constitutive (HO-2) isoforms, catalyzes the degradation of heme to biliverdin and CO in…”
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Cell-free oxygen carriers: Scientific foundations, clinical development, and new directions by Winslow, Robert M.

“…The most significant hurdle to the development of a safe and effective hemoglobin-based oxygen carrier (“blood substitute”) is generally thought to be its…”
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Kinetics of NO and O2 binding to a maleimide poly(ethylene glycol)-conjugated human haemoglobin by Vandegriff, Kim D, Bellelli, Andrea, Samaja, Michele, Malavalli, Ashok, Brunori, Maurizio, Winslow, Robert M

“…The hypertensive effect observed with most cell-free haemoglobins has been proposed to result from NO scavenging. However, a newly developed PEG [poly(ethylene…”
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Sites of Modification of Hemospan, a Poly(ethylene glycol)-Modified Human Hemoglobin for Use As an Oxygen Therapeutic by Vandegriff, Kim D, Malavalli, Ashok, Mkrtchyan, Gnel M, Spann, Stephanie N, Baker, Dale A, Winslow, Robert M

“…Hemospan is an acellular hemoglobin-based oxygen therapeutic in clinical trials in Europe and the United States. The product is prepared by site-specific…”
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NEW TRANSFUSION STRATEGIES: Red Cell Substitutes by Winslow, MD, Robert M

“…Red cell substitutes are solutions that can potentially be used in emergencies or during surgery when rapid expansion of the blood volume with an oxygen…”
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Progress in the development of RBC substitutes by Stowell, Christopher P., Levin, Jack, Spiess, Bruce D., Winslow, Robert M.

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Red Cell Substitutes by Winslow, Robert M

“…Oxygen-carrying plasma expanders (blood substitutes) have been sought for over a century. Development of current products is a result of evolution in the…”
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The role of hemoglobin oxygen affinity in oxygen transport at high altitude by Winslow, Robert M

“…Abstract Hemoglobin is involved in the regulation of O2 transport in two ways: a long-term adjustment in red cell mass is mediated by erythropoietin (EPO), a…”
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Hemospan Improves Outcome in a Model of Perioperative Hemodilution and Blood Loss in the Rat: Comparison With Hydroxyethyl Starch by Young, Mark A., PhD, Lohman, Jeff, BS, Malavalli, Ashok, MS, Vandegriff, Kim D., PhD, Winslow, Robert M., MD

“…Objectives Hemospan (Sangart Inc, San Diego, CA) (MP4) is a hemoglobin-based oxygen carrier consisting of human hemoglobin modified with polyethylene glycol…”
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Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers by Tsai, Amy G., Cabrales, Pedro, Manjula, Belur N., Acharya, Seetharama A., Winslow, Robert M., Intaglietta, Marcos

“…Cell-free hemoglobin's (CFH) high affinity for nitric oxide (NO) could limit CFH's use as an oxygen-carrying blood replacement fluid because it scavenges NO,…”
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Targeted O2 delivery by low-P50 hemoglobin: a new basis for O2 therapeutics by Tsai, Amy G, Vandegriff, Kim D, Intaglietta, Marcos, Winslow, Robert M

“…To assess O2 delivery to tissue by a new surface-modified, polyethylene glycol-conjugated human hemoglobin [MP4; Po2 at 50% saturation of hemoglobin (P50); 5.4…”
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Hemospan: Design Principles for a New Class of Oxygen Therapeutic by Vandegriff, Kim D., Winslow, Robert M.

“…Hemoglobin‐based oxygen carriers have been under development for decades, but safety concerns have prevented commercial approval. Early designs for modified…”
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Red cell age and loss of function: advance or SNO-job? by Winslow, Robert M., Intaglietta, Marcos

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Microvascular oxygen distribution in awake hamster window chamber model during hyperoxia by Tsai, Amy G, Cabrales, Pedro, Winslow, Robert M, Intaglietta, Marcos

“…The microvascular effects and hemodynamic events following exposure to normobaric hyperoxia (because of inspiration of 100% O2) were studied in the awake…”
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