Orexin 2 receptor regulation of the hypothalamic-pituitary-adrenal (HPA) response to acute and repeated stress

Highlights • Orexin activation and levels in csf decrease throughout repeated restraint. • OX2 R promotes HPA response to acute stress. • When orexin levels are high, OX2 R reduces habituation to repeated restraint. • OX1 R may promote habituation of HPA responses to repeated restraint.

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Bibliographic Details
Published in:	Neuroscience Vol. 348; pp. 313 - 323
Main Authors:	Grafe, Laura A, Eacret, Darrell, Luz, Sandra, Gotter, Anthony L, Renger, John J, Winrow, Chris J, Bhatnagar, Seema
Format:	Journal Article
Language:	English
Published:	United States Elsevier Ltd 21-04-2017
Subjects:	Adrenocorticotropic Hormone - blood Animals DREADDs habituation Habituation, Psychophysiologic - drug effects Habituation, Psychophysiologic - physiology hypocretin Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - metabolism Male MK-1064 Neurology Neurons - drug effects Neurons - metabolism orexin receptor Orexin Receptor Antagonists - pharmacology Orexin Receptors - metabolism Orexins - metabolism Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - metabolism Rats Rats, Sprague-Dawley Restraint, Physical stress Stress, Psychological - metabolism Stress, Psychological - physiopathology MK-1064 DREADDs Hypocretin Stress orexin receptor Habituation hypocretin stress habituation
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Summary:	Highlights • Orexin activation and levels in csf decrease throughout repeated restraint. • OX2 R promotes HPA response to acute stress. • When orexin levels are high, OX2 R reduces habituation to repeated restraint. • OX1 R may promote habituation of HPA responses to repeated restraint.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2017.02.038