Search Results - "Winrow, CJ"

Discovery and development of orexin receptor antagonists as therapeutics for insomnia by Winrow, C J, Renger, J J

“…Insomnia persistently affects the quality and quantity of sleep. Currently approved treatments for insomnia primarily target γ‐aminobutyric acid‐A (GABA‐A)…”
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0103 REM SLEEP IS INDUCED BY DUAL AND OREXIN 2 RECEPTOR ANTAGONISTS VIA MECHANISMS BEYOND ALPHA1-NORADRENERGIC SIGNALING by Gotter, AL, Stevens, J, Garson, SL, Fox, SV, Svetnik, V, 
Tannenbaum, PL, Forman, MS, Coleman, PJ, Herring, WJ, 
Renger, JJ, Winrow, CJ

“…Abstract Introduction: Orexin receptor (OX1R, OX2R) antagonism induces sleep architecture characterized by increases in both NREM and REM reminiscent of…”
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0018 DATA MINING OF MULTIPLE GENOMICS DATASETS UNCOVERS CONVERGENT GENE NETWORKS INTEGRATING CIRCADIAN TIMING AND HOMEOSTATIC DRIVE FOR SLEEP REGULATION by Jiang, P, Scarpa, JR, Gao, VD, Fitzpatrick, K, Gotter, A, 
Winrow, CJ, Renger, JJ, Vitaterna, MH, Kasarskis, A, Turek, FW

“…Abstract Introduction: The timing and propensity of sleep are regulated by two interactive processes: circadian rhythmicity and sleep homeostasis. It has been…”
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0280 A RECIPROCAL RELATIONSHIP BETWEEN SLEEP AND ALZHEIMER’S DISEASE? by Kalinina, J, Brunner, J, Yao, L, Hatcher, NG, Gehrman, PR, 
Kling, MA, Shaw, LM, Gooneratne, NS, Chahine, LM, Winrow, CJ, Gotter, AL

“…Abstract Introduction: Sleep-wake cycling is a vital brain function associated with cognition and synaptic plasticity. An intriguing relationship between sleep…”
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Evidence That Mouse Brain Neuropathy Target Esterase Is a Lysophospholipase by Quistad, Gary B., Barlow, Carrolee, Winrow, Christopher J., Sparks, Susan E., Casida, John E.

“…Neuropathy target esterase (NTE) is inhibited by several organophosphorus (OP) pesticides, chemical warfare agents, lubricants, and plasticizers, leading to…”
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Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity by Barlow, Carrolee, Winrow, Christopher J, Hemming, Matthew L, Allen, Duane M, Quistad, Gary B, Casida, John E

“…Neuropathy target esterase (NTE) is involved in neural development and is the target for neurodegeneration induced by selected organophosphorus pesticides and…”
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0018 DATA MINING OF MULTIPLE GENOMICS DATASETS UNCOVERS CONVERGENT GENE NETWORKS INTEGRATING CIRCADIAN TIMING AND HOMEOSTATIC DRIVE FOR SLEEP REGULATION by Jiang, P, Scarpa, JR, Gao, VD, Fitzpatrick, K, Gotter, A, 
Winrow, CJ, Renger, JJ, Vitaterna, MH, Kasarskis, A, Turek, FW

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Ataxia telangiectasia mutated is essential during adult neurogenesis by Allen, D M, van Praag, H, Ray, J, Weaver, Z, Winrow, C J, Carter, T A, Braquet, R, Harrington, E, Ried, T, Brown, K D, Gage, F H, Barlow, C

“…Ataxia telangiectasia (A-T) is an autosomal recessive disease characterized by normal brain development followed by progressive neurodegeneration. The gene…”
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The Peroxisome Proliferator Response Element of the Gene Encoding the Peroxisomal β-Oxidation Enzyme Enoyl-CoA Hydratase/3-Hydroxyacyl-CoA Dehydrogenase Is a Target for Constitutive Androstane Receptor β/9-cis-Retinoic Acid Receptor-mediated Transactivation by Kassam, Altaf, Winrow, Christopher J., Fernandez-Rachubinski, Françoise, Capone, John P., Rachubinski, Richard A.

“…The genes encoding the first two enzymes of the peroxisomal β-oxidation pathway, acyl-CoA oxidase (AOx) and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase…”
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Aberrant recombination involving the granzyme locus occurs in Atm−/− T-cell lymphomas by Winrow, Christopher J., Pankratz, Daniel G., Vibat, Cecile Rose T., Bowen, T.J., Callahan, Marie A., Warren, Amy J., Hilbush, Brian S., Wynshaw-Boris, Anthony, Hasel, Karl W., Weaver, Zoë, Lockhart, David J., Barlow, Carrolee

“…Ataxia telangiectasia (A-T) is an autosomal recessive disease caused by loss of function of the serine/threonine protein kinase ATM (ataxia telangiectasia…”
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Crosstalk between the thyroid hormone and peroxisome proliferator-activated receptors in regulating peroxisome proliferator-responsive genes by Hunter, John, Kassam, Altaf, Winrow, Christopher J., Rachubinski, Richard A., Capone, John P.

“…Peroxisome proliferators and thyroid hormones have overlapping metabolic effects and regulate a similar subset of genes involved in maintaining lipid…”
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Cross-talk between Orphan Nuclear Hormone Receptor RZRα and Peroxisome Proliferator-activated Receptor α in Regulation of the Peroxisomal Hydratase-Dehydrogenase Gene by Winrow, Christopher J., Capone, John P., Rachubinski, Richard A.

“…The genes encoding the peroxisomal β-oxidation enzymes enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase (HD) and fatty acyl-CoA oxidase (AOx) are…”
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A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor by Marcus, S L, Winrow, C J, Capone, J P, Rachubinski, R A

“…Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII), an orphan member of the nuclear hormone receptor superfamily, acts as a…”
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Interplay of the peroxisome proliferator-activated receptor and the thyroid hormone receptor-signaling pathways in regulating peroxisome proliferator-responsive genes by Winrow, C J, Kassam, A, Miyata, K S, Marcus, S L, Hunter, J, Capone, J P, Rachubinski, R A

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Calreticulin modulates the in vitro DNA binding but not the in vivo transcriptional activation by peroxisome proliferator-activated receptor/retinoid X receptor heterodimers by Winrow, Christopher J., Miyata, Kenji S., Marcus, Sandra L., Burns, Kimberly, Michalak, Marek, Capone, John P., Rachubinski, Richard A.

“…Calreticulin is a ubiquitous calcium binding/storage protein found primarily in the endoplasmic reticulum. Calreticulin has been shown to inhbit DNA binding…”
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