Search Results - "Winquist, Alicia"
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Three-dimensional scaffolding to investigate neuronal derivatives of human embryonic stem cells
Published in Biomedical microdevices (01-10-2012)“…Access to unlimited numbers of live human neurons derived from stem cells offers unique opportunities for in vitro modeling of neural development,…”
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Reversal of Surfactant Protein B Deficiency in Patient Specific Human Induced Pluripotent Stem Cell Derived Lung Organoids by Gene Therapy
Published in Scientific reports (17-09-2019)“…Surfactant protein B (SFTPB) deficiency is a fatal disease affecting newborn infants. Surfactant is produced by alveolar type II cells which can be…”
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Generation of Complete Multi-Cell Type Lung Organoids From Human Embryonic and Patient-Specific Induced Pluripotent Stem Cells for Infectious Disease Modeling and Therapeutics Validation
Published in Current protocols in stem cell biology (01-09-2020)“…The normal development of the pulmonary system is critical to transitioning from placental-dependent fetal life to alveolar-dependent newborn life. Human lung…”
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Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease
Published in Journal of visualized experiments (12-04-2021)“…Human lung development and disease has been difficult to study due to the lack of biologically relevant in vitro model systems. Human induced pluripotent stem…”
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Quantitative Analysis of Human Pluripotency and Neural Specification by In-Depth (Phospho)Proteomic Profiling
Published in Stem cell reports (13-09-2016)“…Controlled differentiation of human embryonic stem cells (hESCs) can be utilized for precise analysis of cell type identities during early development. We…”
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Valproate reverses mania-like behaviors in mice via preferential targeting of HDAC2
Published in Molecular psychiatry (01-08-2021)“…Valproate (VPA) has been used in the treatment of bipolar disorder since the 1990s. However, the therapeutic targets of VPA have remained elusive. Here we…”
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