Search Results - "Winnischofer, Sheila M. B."

Substituted Chromones as Highly Potent Nontoxic Inhibitors, Specific for the Breast Cancer Resistance Protein by Valdameri, Glaucio, Genoux-Bastide, Estelle, Peres, Basile, Gauthier, Charlotte, Guitton, Jérôme, Terreux, Raphaël, Winnischofer, Sheila M. B, Rocha, Maria E. M, Boumendjel, Ahcène, Di Pietro, Attilio

“…A series of 13 disubstituted chromones was synthesized. Two types of substituents, on each side of the scaffold, contributed to both the potency of ABCG2…”
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Dual properties of hispidulin: antiproliferative effects on HepG2 cancer cells and selective inhibition of ABCG2 transport activity by Scoparo, Carina T., Valdameri, Glaucio, Worfel, Paulo R., Guterres, Fernanda A. L. B., Martinez, Glaucia R., Winnischofer, Sheila M. B., Di Pietro, Attilio, Rocha, Maria E. M.

“…Hepatocellular carcinoma is the third most common cause of cancer-related deaths worldwide. Furthermore, the existing pharmacological-based treatments are…”
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Methoxy Stilbenes as Potent, Specific, Untransported, and Noncytotoxic Inhibitors of Breast Cancer Resistance Protein by Valdameri, Glaucio, Pereira Rangel, Luciana, Spatafora, Carmela, Guitton, Jérôme, Gauthier, Charlotte, Arnaud, Ophélie, Ferreira-Pereira, Antonio, Falson, Pierre, Winnischofer, Sheila M. B, Rocha, Maria E. M, Tringali, Corrado, Di Pietro, Attilio

“…The ABCG2 multidrug transporter is known to confer cancer cell multidrug resistance by causing the efflux of anticancer drugs; therefore, selective inhibitors…”
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Investigation of Chalcones as Selective Inhibitors of the Breast Cancer Resistance Protein: Critical Role of Methoxylation in both Inhibition Potency and Cytotoxicity by Valdameri, Glaucio, Gauthier, Charlotte, Terreux, Raphaël, Kachadourian, Rémy, Day, Brian J, Winnischofer, Sheila M. B, Rocha, Maria E. M, Frachet, Véronique, Ronot, Xavier, Di Pietro, Attilio, Boumendjel, Ahcène

“…ABCG2 plays a major role in anticancer-drug efflux and related tumor multidrug resistance. Potent and selective ABCG2 inhibitors with low cytotoxicity were…”
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Impact of Reck expression and promoter activity in neuronal in vitro differentiation by Trombetta-Lima, Marina, Assis-Ribas, Thais, Cintra, Ricardo C., Campeiro, Joana D., Guerreiro, Juliano R., Winnischofer, Sheila M. B., Nascimento, Isis C. C., Ulrich, Henning, Hayashi, Mirian A. F., Sogayar, Mari C.

“…Reck (REversion-inducing Cysteine-rich protein with Kazal motifs) tumor suppressor gene encodes a multifunctional glycoprotein which inhibits the activity of…”
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Melanogenesis stimulation in B16-F10 melanoma cells induces cell cycle alterations, increased ROS levels and a differential expression of proteins as revealed by proteomic analysis by Cunha, Elizabeth S., Kawahara, Rebeca, Kadowaki, Marina K., Amstalden, Hudson G., Noleto, Guilhermina R., Cadena, Silvia Maria S.C., Winnischofer, Sheila M.B., Martinez, Glaucia R.

“…Considering that stimulation of melanogenesis may lead to alterations of cellular responses, besides melanin production, our main goal was to study the…”
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Antioxidant, antibacterial and antitumoural activities of kraft lignin from hardwood fractionated by acid precipitation by Lourençon, Tainise V., de Lima, Gabriel G., Ribeiro, Carolina S.P., Hansel, Fabricio A., Maciel, Giselle M., da Silva, Krisle, Winnischofer, Sheila M.B., de Muniz, Graciela I.B., Magalhães, Washington L.E.

“…Kraft lignin, so far useful for energy generation, has been gathering considerable attention as an alternative material to replace fossil-based resources…”
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Lipid profile in breast cancer: From signaling pathways to treatment strategies by Taborda Ribas, Hennrique, Sogayar, Mari C., Dolga, Amalia M., Winnischofer, Sheila M.B., Trombetta-Lima, Marina

“…Breast cancer is the most prevalent cancer in women. Metabolic abnormalities, particularly increased lipid synthesis and uptake, impact the onset and…”
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Dietary fibres from guavira pomace, a co-product from fruit pulp industry: Characterization and cellular antioxidant activity by Schneider, Vanessa Suzane, Bark, Juliana Müller, Winnischofer, Sheila M.B., Dos Santos, Elisvânia Freitas, Iacomini, Marcello, Cordeiro, Lucimara M.C.

“…[Display omitted] •Guavira pomace is an agroindustrial waste of guavira pulp industry.•It was a source of arabinan, homogalacturonan and arabinogalactan.•These…”
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Structure and intracellular antioxidant activity of pectic polysaccharide from acerola (Malpighia emarginata) by Klosterhoff, Rafael Roberto, Bark, Juliana Müller, Glänzel, Nícolas Manzke, Iacomini, Marcello, Martinez, Gláucia Regina, Winnischofer, Sheila M.B., Cordeiro, Lucimara M.C.

“…Malpighia emarginata is a tropical fruit plant, found naturally in the Caribbean islands and South America that produces an edible fruit known as acerola or…”
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Semi-synthesis of hybrid ulvan-kappa-carrabiose polysaccharides and evaluation of their cytotoxic and anticoagulant effects by Colodi, Franciely G., Ducatti, Diogo R.B., Noseda, Miguel D., de Carvalho, Mariana M., Winnischofer, Sheila M.B., Duarte, Maria Eugênia R.

“…In this study we described the synthesis of a hybrid polysaccharide harboring moieties of ulvan and kappa-carrabiose. Alkylamines (1,3-diaminopropane and…”
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Anti-proliferative and cytotoxic activities of the flavonoid isoliquiritigenin in the human neuroblastoma cell line SH-SY5Y by Escobar, Stephane J.de M., Fong, Genevieve M., Winnischofer, Sheila M.B., Simone, Martin, Munoz, Lenka, Dennis, Joanne M., Rocha, Maria Eliane M., Witting, Paul K.

“…Neuroblastoma is a common childhood cancer with high mortality. We evaluated the capacity of the flavonoid, isoliquiritigenin (4,2’,4’-trihydroxychalcone; ISL)…”
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Chemical structure of native and modified sulfated heterorhamnans from the green seaweed Gayralia brasiliensis and their cytotoxic effect on U87MG human glioma cells by Mazepa, Ester, Noseda, Miguel D., Ferreira, Luciana G., de Carvalho, Mariana M., Gonçalves, Alan G., Ducatti, Diogo R.B., de L. Bellan, Daniel, Gomes, Rafaela P., da S. Trindade, Edvaldo, Franco, Célia R.C., Pellizzari, Franciane M., Winnischofer, Sheila M.B., Duarte, Maria E.R.

“…A water-soluble sulfated heterorhamnan (Gb1) was isolated from the green seaweed Gayralia brasiliensis and purified by ultrafiltration, yielding a homogeneous…”
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Sulfated heterorhamnans from the green seaweed Gayralia oxysperma: partial depolymerization, chemical structure and antitumor activity by Ropellato, Juliana, Carvalho, Mariana M., Ferreira, Luciana G., Noseda, Miguel D., Zuconelli, Cristiane R., Gonçalves, Alan G., Ducatti, Diogo R.B., Kenski, Juliana C.N., Nasato, Pauline. L., Winnischofer, Sheila M.B., Duarte, Maria E.R.

“…•Smith-degraded polysaccharides were obtained from sulfated heterorhamnans.•The homogeneous fractions are highly sulfated and present Mwof 109 and…”
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Characterization of 2,3,6,7,10,11-hexahydroxytriphenylene and its effects on cell viability in human cancer cell lines by Naidek, Karine P, Zuconelli, Cristiane R, Cruz, Otavio M, Ribeiro, Ronny, Winnischofer, Sheila M B, Winnischofer, Herbert

“…We synthesized 2,3,6,7,10,11-hexahydroxytriphenylene (HHTP), characterized it by electrochemistry, spectroelectrochemistry, and electron paramagnetic resonance…”
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Involvement of catalase in the apoptotic mechanism induced by apigenin in HepG2 human hepatoma cells by Valdameri, Glaucio, Trombetta-Lima, Marina, Worfel, Paulo R., Pires, Amanda R.A., Martinez, Glaucia R., Noleto, Guilhermina R., Cadena, Silvia M.S.C., Sogayar, Mari C., Winnischofer, Sheila M.B., Rocha, Maria E.M.

“…► Antioxidant enzymes in the apoptotic mechanism induced by apigenin in HepG2 cells. ► Catalase downregulation play an essential role in apigenin-induced…”
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Glutathione modifies the oxidation products of 2′-deoxyguanosine by singlet molecular oxygen by Peres, Patrícia S., Valerio, Andressa, Cadena, Silvia M.S.C., Winnischofer, Sheila M.B., Scalfo, Alexsandra C., Di Mascio, Paolo, Martinez, Glaucia R.

“…The oxidation of the free nucleoside 2′-deoxyguanosine (dGuo) by singlet molecular oxygen (1O2) has been studied over the three last decades due to the major…”
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Downregulation of reversion-inducing cysteine-rich protein with Kazal motifs in malignant melanoma: inverse correlation with membrane-type 1-matrix metalloproteinase and tissue inhibitor of metalloproteinase 2 by Jacomasso, Thiago, Trombetta-Lima, Marina, Sogayar, Mari C, Winnischofer, Sheila M B

“…The invasive phenotype of many tumors is associated with an imbalance between the matrix metalloproteinases (MMPs) and their inhibitors, tissue inhibitors of…”
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6-Halogenochromones Bearing Tryptamine: One-Step Access to Potent and Highly Selective Inhibitors of Breast Cancer Resistance Protein by Valdameri, Glaucio, Genoux-Bastide, Estelle, Gauthier, Charlotte, Peres, Basile, Terreux, Raphaël, Winnischofer, Sheila M. B., Rocha, Maria E. M., Di Pietro, Attilio, Boumendjel, Ahcène

“…Easy as A B C! 6‐Halochromone derivatives bearing a tryptamine moiety were evaluated as inhibitors of the breast cancer resistance protein (BCRP)/ABCG2. The…”
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Flavone induces cell death in human hepatoma HepG2 cells by Valdameri, Glaucio, Kenski, Juliana C N, Moure, Vivian R, Trombetta-Lima, Marina, Martinez, Glaucia R, Sogayar, Mari C, Winnischofer, Sheila M B, Rocha, Maria E M

“…Flavones have received considerable attention because of their antiproliferative properties and selective effects on cancer cells, making them good candidates…”
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