Search Results - "Winnike, Jason H"

Microbial modulation of host body composition and plasma metabolic profile by Nazmul Huda, M., Winnike, Jason H., Crowell, Jocelyn M., O’Connor, Annalouise, Bennett, Brian J.

“…The gut microbiota is a critical mediator of nutrition and disease risk. Like most complex traits, the microbiome is under genetic regulation and differs…”
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Effects of a prolonged standardized diet on normalizing the human metabolome by Winnike, Jason H, Busby, Marjorie G, Watkins, Paul B, O'Connell, Thomas M

“…BACKGROUND: Although the effects of acute dietary interventions on the human metabolome have been studied, the extent to which the metabolome can be normalized…”
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Stable Isotope-Resolved Metabolomic Differences between Hormone-Responsive and Triple-Negative Breast Cancer Cell Lines by McRitchie, Susan L., Pathmasiri, Wimal W., Stewart, Delisha A., Winnike, Jason H., Sumner, Susan J.

“…Purpose. To conduct an exploratory study to identify mechanisms that differentiate Luminal A (BT474 and MCF-7) and triple-negative (MDA-MB-231 and MDA-MB-468)…”
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Comparison of GC-MS and GC×GC-MS in the Analysis of Human Serum Samples for Biomarker Discovery by Winnike, Jason H, Wei, Xiaoli, Knagge, Kevin J, Colman, Steven D, Gregory, Simon G, Zhang, Xiang

“…We compared the performance of gas chromatography time-of-flight mass spectrometry (GC-MS) and comprehensive two-dimensional gas chromatography mass…”
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Metabolomics Analysis of Hormone-Responsive and Triple-Negative Breast Cancer Cell Responses to Paclitaxel Identify Key Metabolic Differences by Stewart, Delisha A, Winnike, Jason H, McRitchie, Susan L, Clark, Robert F, Pathmasiri, Wimal W, Sumner, Susan J

“…To date, no targeted therapies are available to treat triple negative breast cancer (TNBC), while other breast cancer subtypes are responsive to current…”
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Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylation by Fannin, Rick D., Russo, Mark, O'Connell, Thomas M., Gerrish, Kevin, Winnike, Jason H., Macdonald, Jeffrey, Newton, Jack, Malik, Shahid, Sieber, Stella O., Parker, Joel, Shah, Ruchir, Zhou, Tong, Watkins, Paul B., Paules, Richard S.

“…The diagnosis and management of drug‐induced liver injury (DILI) is hindered by the limited utility of traditional clinical chemistries. It has recently been…”
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Cancer cachexia’s metabolic signature in a murine model confirms a distinct entity by Der-Torossian, Hirak, Asher, Scott A., Winnike, Jason H., Wysong, Ashley, Yin, Xiaoying, Willis, Monte S.,  O’Connell, Thomas M., Couch, Marion E.

“…Despite recent consensus definitions, lack of specific biomarkers remains a hurdle towards a more accurate and efficient diagnosis of cancer cachexia,…”
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Stable isotope resolved metabolomics of primary human hepatocytes reveals a stressed phenotype by Winnike, Jason H., Pediaditakis, Peter, Wolak, Justyna E., McClelland, Randall E., Watkins, Paul B., Macdonald, Jeffrey M.

“…The development of techniques allowing the culturing of primary mammalian hepatocytes has provided great insights into liver physiology. For most applications,…”
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Metabolomic analysis of cancer cachexia reveals distinct lipid and glucose alterations by O'Connell, Thomas M, Ardeshirpour, Farhad, Asher, Scott A, Winnike, Jason H, Yin, Xiaoying, George, Jonathan, Guttridge, Denis C, He, Wei, Wysong, Ashley, Willis, Monte S, Couch, Marion E

“…Cancer cachexia remains a challenging clinical problem with complex pathophysiology and unreliable diagnostic tools. A blood test to detect this metabolic…”
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High-throughput nuclear magnetic resonance metabolomic footprinting for tissue engineering by Seagle, Christopher, Christie, Megan A, Winnike, Jason H, McClelland, Randall E, Ludlow, John W, O'Connell, Thomas M, Gamcsik, Michael P, MacDonald, Jeffrey M

“…We report a high-throughput (HTP) nuclear magnetic resonance (NMR) method for analysis of media components and a metabolic schematic to help easily interpret…”
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Effects of a prolonged standardized diet on normalizing the human metabolome12 by Winnike, Jason H, Busby, Marjorie G, Watkins, Paul B, O’Connell, Thomas M

“…Although the effects of acute dietary interventions on the human metabolome have been studied, the extent to which the metabolome can be normalized by extended…”
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Effects of a prolonged standardized diet on normalizing the human metabolome123 by Winnike, Jason H, Busby, Marjorie G, Watkins, Paul B, O'Connell, Thomas M

“…Background: Although the effects of acute dietary interventions on the human metabolome have been studied, the extent to which the metabolome can be normalized…”
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The Metabolomics of Acetaminophen Toxicity Observed in Human Biofluids and Cultured Primary Human Hepatocytes by Winnike, Jason H

“…The mechanisms of acetaminophen toxicity are well-established. However, the use of metabolomics to identify small molecule (< 1 kD) biomarkers of acetaminophen…”
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The metabolomics of acetaminophen toxicity observed in human biofluids and cultured primary human hepatocytes by Winnike, Jason H

“…The mechanisms of acetaminophen toxicity are well-established. However, the use of metabolomics to identify small molecule (< 1 kD) biomarkers of acetaminophen…”
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