Search Results - "Winnik, Witold M."

Proteome Profiling of Rat Brain Cortical Changes during Early Postnatal Brain Development by Winnik, Witold M., Padgett, William, Pitzer, Emily M., Herr, David W.

“…Label-free quantitation (LFQ) was applied to proteome profiling of rat brain cortical development during the early postnatal period. Male and female rat brain…”
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Acute phase response, inflammation and metabolic syndrome biomarkers of Libby asbestos exposure by Shannahan, Jonathan H., Alzate, Oscar, Winnik, Witold M., Andrews, Debora, Schladweiler, Mette C., Ghio, Andrew J., Gavett, Stephen H., Kodavanti, Urmila P.

“…Identification of biomarkers assists in the diagnosis of disease and the assessment of health risks from environmental exposures. We hypothesized that rats…”
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Proteomics Reveals Divergent Cardiac Inflammatory and Metabolic Responses After Inhalation of Ambient Particulate Matter With or Without Ozone by Ge, Yue, Nash, Maliha S., Winnik, Witold M., Bruno, Maribel, Padgett, William T., Grindstaff, Rachel D., Hazari, Mehdi S., Farraj, Aimen K.

“…Inhalation of ambient particulate matter (PM) and ozone (O 3 ) has been associated with increased cardiovascular morbidity and mortality. However, the…”
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Proteomic analysis optimization: Selective protein sample on-column retention in reverse-phase liquid chromatography by Winnik, Witold M., Ortiz, Pedro A.

“…In an effort to optimize reverse-phase liquid chromatography (RPLC) for proteomics, we studied the impact of composition of the sample injection solution on…”
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Developmental exposure to a commercial PBDE mixture: effects on protein networks in the cerebellum and hippocampus of rats by Kodavanti, Prasada Rao S, Royland, Joyce E, Osorio, Cristina, Winnik, Witold M, Ortiz, Pedro, Lei, Lei, Ramabhadran, Ram, Alzate, Oscar

“…Polybrominated diphenyl ethers (PBDEs) are structurally similar to polychlorinated biphenyls (PCBs) and have both central (learning and memory deficits) and…”
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Investigation of an enhanced resolution triple quadrupole mass spectrometer for high-throughput liquid chromatography/tandem mass spectrometry assays by Yang, Liyu, Amad, Ma'an, Winnik, Witold M., Schoen, Alan E., Schweingruber, Hans, Mylchreest, Iain, Rudewicz, Patrick J.

“…Triple quadrupole mass spectrometers, when operated in multiple reaction monitoring (MRM) mode, offer a unique combination of sensitivity, specificity, and…”
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Novel molecular events associated with altered steroidogenesis induced by exposure to atrazine in the intact and castrate male rat by Riffle, Brandy W., Klinefelter, Gary R., Cooper, Ralph L., Winnik, Witold M., Swank, Adam, Jayaraman, Saro, Suarez, Juan, Best, Deborah, Laws, Susan C.

“…•Atrazine increases serum progesterone and corticosterone in both intact and castrate male rats.•Luteinizing hormone, androstenedione and testosterone were…”
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Continuous pH/Salt Gradient and Peptide Score for Strong Cation Exchange Chromatography in 2D-Nano-LC/MS/MS Peptide Identification for Proteomics by Winnik, Witold M

“…Tryptic digests of human serum albumin and human lung epithelial cell lysates were used as test samples in a novel proteomics study. Peptides were separated…”
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Novel molecular targets associated with testicular dysgenesis induced by gestational exposure to diethylhexyl phthalate in the rat: a role for estradiol by Klinefelter, Gary R, Laskey, John W, Winnik, Witold M, Suarez, Juan D, Roberts, Naomi L, Strader, Lillian F, Riffle, Brandy W, Veeramachaneni, D N Rao

“…Significant research has been focused on phthalate-induced alterations in male reproductive development. Studies on rodents have prompted the notion that a…”
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Systematic Proteomic Approach to Characterize the Impacts of Chemical Interactions on Protein and Cytotoxicity Responses to Metal Mixture Exposures by Ge, Yue, Bruno, Maribel, Wallace, Kathleen, Leavitt, Sharon, Andrews, Debora, Spassova, Maria A, Xi, Mingyu, Roy, Anindya, Haykal-Coates, Najwa, Lefew, William, Swank, Adam, Winnik, Witold M, Chen, Chao, Woodard, Jonne, Farraj, Aimen, Teichman, Kevin Y, Ross, Jeffrey A

“…Chemical interactions have posed a big challenge in toxicity characterization and human health risk assessment of environmental mixtures. To characterize the…”
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Simultaneous Detection of Changes in Protein Expression and Oxidative Modification as a Function of Age and APOE Genotype by DeKroon, Robert M, Osorio, Cristina, Robinette, Jennifer B, Mocanu, Mihaela, Winnik, Witold M, Alzate, Oscar

“…To better elucidate temporal changes in protein oxidation resulting from aging and the Alzheimer’s disease-associated Apolipoprotein E (ApoE), we developed a…”
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Measurement of oxidative stress parameters using liquid chromatography–tandem mass spectroscopy (LC–MS/MS) by Winnik, Witold M., Kitchin, Kirk T.

“…There is increasingly intense scientific and clinical interest in oxidative stress and the many parameters used to quantify the degree of oxidative stress…”
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Proteomic analysis of mice expressing human ApoE demonstrates no differences in global protein solubility between APOE 3 and APOE 4 young mice by Londono, Carolina, DeKroon, Robert M., Mocanu, Mihaela, Booe, Jessica, Winnik, Witold M., Swank, Adam, Osorio, Cristina, Hamlett, Eric D., Alzate, Oscar

“…Apolipoprotein E (ApoE) is a major lipid carrier protein. In humans, ApoE is expressed in three polymorphic isoforms, which are encoded by three different…”
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Proteomic analysis of mice expressing human A po E demonstrates no differences in global protein solubility between APOE 3 and APOE 4 young mice by Londono, Carolina, DeKroon, Robert M., Mocanu, Mihaela, Booe, Jessica, Winnik, Witold M., Swank, Adam, Osorio, Cristina, Hamlett, Eric D., Alzate, Oscar

“…Apolipoprotein E ( A po E ) is a major lipid carrier protein. In humans, A po E is expressed in three polymorphic isoforms, which are encoded by three…”
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Early alterations in protein and gene expression in rat kidney following bromate exposure by Ahlborn, Gene J., Delker, Don A., Roop, Barbara C., Geter, David R., Allen, James W., DeAngelo, Anthony B., Winnik, Witold M.

“…Bromate, a common disinfectant byproduct of drinking water ozonation, has been linked to human and animal renal toxicity, including renal cell carcinomas in…”
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Analysis of proteins using DIGE and MALDI mass spectrometry by Winnik, Witold M, Dekroon, Robert M, Jeong, Joseph S Y, Mocanu, Mihaela, Robinette, Jennifer B, Osorio, Cristina, Dicheva, Nedyalka N, Hamlett, Eric, Alzate, Oscar

“…Difference gel electrophoresis (DIGE) is a common technique for characterizing differential protein expression in quantitative proteomics. Usually a…”
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Proteomic profiles of liver microsomes from mice treated with the hepatotumorigenic conazole, triadimefon by Ortiz, Pedro A., Chen, Pei‐Jen, Moore, Tanya, Nesnow, Stephen, Winnik, Witold M.

“…Abstract only Triadimefon is a triazole‐based conazole fungicide used in agriculture. This conazole is hepatotoxic and hepatotumorigenic in mice. As part of a…”
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