Search Results - "Winneker, R C"

Progress and Prospects in Treating Postmenopausal Vaginal Atrophy by Winneker, R C, Harris, H A

“…Anatomically described as a “potential space,” the vagina is a highly estrogen‐responsive organ, and its biology changes dramatically at menopause. After…”
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Selective and opposing actions of progesterone receptor isoforms in human endometrial stromal cells by Yudt, M.R., Berrodin, T.J., Jelinsky, S.A., Hanna, L.A., Brown, E.L., Chippari, S., Bhat, R.A., Winneker, R.C., Zhang, Z.

“…Transcriptional regulation by progesterone is mediated primarily through the two progesterone receptor (PR) isoforms, PR-A and PR-B. Primary human endometrial…”
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The effect of estrogens and antiestrogens in a rat model for hot flush by Merchenthaler, Istvan, Funkhouser, Judith M., Carver, Jeffrey M., Lundeen, Scott G., Ghosh, Krishnendu, Winneker, Richard C.

“…The present studies evaluated the effect of estrogens and the selective estrogen receptor modulator (SERM) tamoxifen and raloxifene in a rat model for hot…”
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In vitro characterization of trimegestone: a new potent and selective progestin by Zhang, Zhiming, Lundeen, Scott G, Zhu, Yuan, Carver, Jeffrey M, Winneker, Richard C

“…Trimegestone (TMG) is a novel 19-norpregnane progestin under development for hormone replacement therapy and oral contraception. The objective of the current…”
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Differential effects of estrogens and progestins on the anticoagulant tissue factor pathway inhibitor in the rat by Shirk, Rebecca A., Zhang, Zhiming, Winneker, Richard C.

“…Oral contraceptives (OC) and postmenopausal hormone therapy (HT) modulate plasma levels of proteins that regulate blood coagulation. It remains unclear whether…”
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Serotonin 5-HT1 receptors potentiate histamine and thrombin stimulated prostaglandin synthesis in endothelial cells by Kilbourne, E J, Winneker, R C

“…The ability of serotonin 5-HT1 receptors to increase vascular tone was previously found to be activated by vasoconstrictiors such as histamine. In this study,…”
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The effect of the steroidal androgen receptor antagonist, Win 49,596, on the prostate and testis of beagle dogs by Juniewicz, P E, McCarthy, M, Lemp, B M, Barbolt, T A, Shaw, C, Hollenbaugh, D M, Winneker, R C, Reel, J R, Batzold, F H

“…The effect of the steroidal androgen receptor antagonist Win 49,596 on the prostate and testis was studied in beagle dogs and was compared to the effects of…”
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Molecular and Pharmacological Properties of a Potent and Selective Novel Nonsteroidal Progesterone Receptor Agonist Tanaproget by Zhang, Zhiming, Olland, Andrea M, Zhu, Yuan, Cohen, Jeff, Berrodin, Tom, Chippari, Susan, Appavu, Chandrasekaran, Li, Shen, Wilhem, James, Chopra, Raj, Fensome, Andrew, Zhang, Puwen, Wrobel, Jay, Unwalla, Rayomand J, Lyttle, C Richard, Winneker, Richard C

“…Progesterone receptor (PR) agonists have several important applications in women's health, such as in oral contraception and post-menopausal hormone therapy…”
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Endocrine profile of Win 49596 in the rat: a novel androgen receptor antagonist by Snyder, B W, Winneker, R C, Batzold, F H

“…Win 49596 is a new orally active, steroidal androgen receptor antagonist. Win 49596 inhibited ventral prostate, seminal vesicle and levator ani weight gain in…”
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Studies on the mechanism of action of danazol and gestrinone (R2323) in the rat: evidence for a masked estrogen component by Snyder, B W, Beecham, G D, Winneker, R C

“…The effects of androgen and estrogen receptor antagonists on the action of danazol and gestrinone (R2323) were investigated. The tropic effect of danazol and…”
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Effect of epostane, ZK 98299, and ZK 98734 on the interruption of pregnancy in the rat by SNYDER, B. W, REEL, J. R, WINNEKER, R. C, BATZOLD, F. H, POTTS, G. O

“…The objective of these studies was to determine whether treatment of 10-day pregnant rats with a combination of epostane (a progesterone biosynthesis…”
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Characterization of the Ovariectomized Rat Model for the Evaluation of Estrogen Effects on Plasma Cholesterol Levels by Lundeen, Scott G, Carver, Jeffrey M, McKean, Mar-Lee, Winneker, Richard C

“…Estrogens protect against cardiovascular disease in women through effects on the vascular wall and liver. Here we further characterize the rat as a model for…”
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Danazol suppression of luteinizing hormone in the rat: evidence for mediation by both androgen and estrogen receptors by Snyder, B W, Beecham, G D, Winneker, R C

“…Previous studies had indicated that the effects of danazol on rat peripheral tissues were mediated through both androgen and estrogen receptors. The purpose of…”
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Rat uterine complement C3 expression as a model for progesterone receptor modulators: characterization of the new progestin trimegestone by Lundeen, Scott G, Zhang, Zhiming, Zhu, Yuan, Carver, Jeffrey M, Winneker, Richard C

“…Progestins have a wide variety of activities in female reproduction. There are also pharmacological applications for progestins, including hormone replacement…”
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Studies on the mechanism of action of Win 49596: a steroidal androgen receptor antagonist by Winneker, R C, Wagner, M M, Batzold, F H

“…Win 49596 is an orally active antiandrogen in the rat. This report describes a series of in vitro and in vivo studies which were performed to characterize the…”
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Antiandrogenic steroidal sulfonyl heterocycles. Utility of electrostatic complementarity in defining bioisosteric sulfonyl heterocycles by Mallamo, John P, Pilling, Garry M, Wetzel, Joseph R, Kowalczyk, Paul J, Bell, Malcolm R, Kullnig, Rudolph K, Batzold, Frederick H, Juniewicz, Paul E, Winneker, Richard C, Luss, Henry R

“…Complementarity of electrostatic potential surface maps was utilized in defining bioisosteric steroidal androgen receptor antagonists. Semiempirical and ab…”
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Antiandrogenic steroidal sulfonylpyrazoles by Christiansen, Robert G, Bell, Malcolm R, D'Ambra, Thomas E, Mallamo, John P, Herrmann, John L, Ackerman, James H, Opalka, Chester J, Kullnig, Rudolph K, Winneker, Richard C

“…The steroidal sulfonylpyrazole 1 bound to the rat ventral prostate androgen receptor in vitro; it inhibited testosterone propionate induced increases in…”
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Quantitative analysis of gene regulation by seven clinically relevant progestins suggests a highly similar mechanism of action through progesterone receptors in T47D breast cancer cells by Bray, Jeffrey D., Jelinsky, Scott, Ghatge, Radhika, Bray, Jenifer A., Tunkey, Christopher, Saraf, Kathryn, Jacobsen, Britta M., Richer, Jennifer K., Brown, Eugene L., Winneker, Richard C., Horwitz, Kathryn B., Lyttle, C. Richard

“…Progesterone (P4) is an essential reproductive steroid hormone required for many aspects of female reproductive physiology. Progestins are compounds that…”
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The preclinical biology of a new potent and selective progestin: trimegestone by Winneker, Richard C, Bitran, Daniel, Zhang, Zhiming

“…Trimegestone (TMG) is a 19-norpregnane progestin being developed, in combination with an estrogen, for the treatment of postmenopausal symptoms. TMG binds to…”
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The angiogenic factor Cyr61 is induced by the progestin R5020 and is necessary for mammary adenocarcinoma cell growth by Sampath, Deepak, Winneker, Richard C, Zhang, Zhiming

“…Cyr61 is a secreted pro-angiogenic factor that belongs to an emerging family of growth regulators classified as CCN (CTGF/Cyr61/NOV). Work in our laboratory…”
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