Search Results - "Winnefeld, Marc"

Acute Activation of Oxidative Pentose Phosphate Pathway as First-Line Response to Oxidative Stress in Human Skin Cells by Kuehne, Andreas, Emmert, Hila, Soehle, Joern, Winnefeld, Marc, Fischer, Frank, Wenck, Horst, Gallinat, Stefan, Terstegen, Lara, Lucius, Ralph, Hildebrand, Janosch, Zamboni, Nicola

“…Integrity of human skin is endangered by exposure to UV irradiation and chemical stressors, which can provoke a toxic production of reactive oxygen species…”
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Integrated analysis of motif activity and gene expression changes of transcription factors by Madsen, Jesper Grud Skat, Rauch, Alexander, Van Hauwaert, Elvira Laila, Schmidt, Søren Fisker, Winnefeld, Marc, Mandrup, Susanne

“…The ability to predict transcription factors based on sequence information in regulatory elements is a key step in systems-level investigation of…”
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Aging and chronic sun exposure cause distinct epigenetic changes in human skin by Grönniger, Elke, Weber, Barbara, Heil, Oliver, Peters, Nils, Stäb, Franz, Wenck, Horst, Korn, Bernhard, Winnefeld, Marc, Lyko, Frank

“…Epigenetic changes are widely considered to play an important role in aging, but experimental evidence to support this hypothesis has been scarce. We have used…”
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Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin by Rodríguez-Paredes, Manuel, Bormann, Felix, Raddatz, Günter, Gutekunst, Julian, Lucena-Porcel, Carlota, Köhler, Florian, Wurzer, Elisabeth, Schmidt, Katrin, Gallinat, Stefan, Wenck, Horst, Röwert-Huber, Joachim, Denisova, Evgeniya, Feuerbach, Lars, Park, Jeongbin, Brors, Benedikt, Herpel, Esther, Nindl, Ingo, Hofmann, Thomas G., Winnefeld, Marc, Lyko, Frank

“…Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and usually progresses from a UV-induced precancerous lesion termed actinic…”
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Single-Cell RNA Profiling of Human Skin Reveals Age-Related Loss of Dermal Sheath Cells and Their Contribution to a Juvenile Phenotype by Ahlers, Juliane M D, Falckenhayn, Cassandra, Holzscheck, Nicholas, Solé-Boldo, Llorenç, Schütz, Sabrina, Wenck, Horst, Winnefeld, Marc, Lyko, Frank, Grönniger, Elke, Siracusa, Annette

“…The dermal sheath (DS) is a population of mesenchyme-derived skin cells with emerging importance for skin homeostasis. The DS includes hair follicle dermal…”
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Identification of new genes involved in human adipogenesis and fat storage by Söhle, Jörn, Machuy, Nikolaus, Smailbegovic, Elma, Holtzmann, Ursula, Grönniger, Elke, Wenck, Horst, Stäb, Franz, Winnefeld, Marc

“…Since the worldwide increase in obesity represents a growing challenge for health care systems, new approaches are needed to effectively treat obesity and its…”
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Epigenetic regulation of depot-specific gene expression in adipose tissue by Gehrke, Sandra, Brueckner, Bodo, Schepky, Andreas, Klein, Johannes, Iwen, Alexander, Bosch, Thomas C G, Wenck, Horst, Winnefeld, Marc, Hagemann, Sabine

“…In humans, adipose tissue is distributed in subcutaneous abdominal and subcutaneous gluteal depots that comprise a variety of functional differences. Whereas…”
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Methacrylated gelatin/hyaluronan-based hydrogels for soft tissue engineering by Kessler, Lukas, Gehrke, Sandra, Winnefeld, Marc, Huber, Birgit, Hoch, Eva, Walter, Torsten, Wyrwa, Ralf, Schnabelrauch, Matthias, Schmidt, Malte, Kückelhaus, Maximilian, Lehnhardt, Marcus, Hirsch, Tobias, Jacobsen, Frank

“…In vitro–generated soft tissue could provide alternate therapies for soft tissue defects. The aim of this study was to evaluate methacrylated…”
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Development of an epigenetic clock to predict visual age progression of human skin by Bienkowska, Agata, Raddatz, Günter, Söhle, Jörn, Kristof, Boris, Völzke, Henry, Gallinat, Stefan, Lyko, Frank, Kaderali, Lars, Winnefeld, Marc, Grönniger, Elke, Falckenhayn, Cassandra

“…Aging is a complex process characterized by the gradual decline of physiological functions, leading to increased vulnerability to age-related diseases and…”
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Identification of dihydromyricetin as a natural DNA methylation inhibitor with rejuvenating activity in human skin by Falckenhayn, Cassandra, Bienkowska, Agata, Söhle, Jörn, Wegner, Katrin, Raddatz, Guenter, Kristof, Boris, Kuck, Dirk, Siegner, Ralf, Kaufmann, Ronny, Korn, Julia, Baumann, Sascha, Lange, Daniela, Schepky, Andreas, Völzke, Henry, Kaderali, Lars, Winnefeld, Marc, Lyko, Frank, Grönniger, Elke

“…Changes in DNA methylation patterning have been reported to be a key hallmark of aged human skin. The altered DNA methylation patterns are correlated with…”
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White Tea extract induces lipolytic activity and inhibits adipogenesis in human subcutaneous (pre)-adipocytes by Söhle, Jörn, Knott, Anja, Holtzmann, Ursula, Siegner, Ralf, Grönniger, Elke, Schepky, Andreas, Gallinat, Stefan, Wenck, Horst, Stäb, Franz, Winnefeld, Marc

“…The dramatic increase in obesity-related diseases emphasizes the need to elucidate the cellular and molecular mechanisms underlying fat metabolism. To…”
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Lotus leaf extract and L-carnitine influence different processes during the adipocyte life cycle by Siegner, Ralf, Heuser, Stefan, Holtzmann, Ursula, Söhle, Jörn, Schepky, Andreas, Raschke, Thomas, Stäb, Franz, Wenck, Horst, Winnefeld, Marc

“…The cellular and molecular mechanisms of adipose tissue biology have been studied extensively over the last two decades. Adipose tissue growth involves both an…”
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A new protocol for functional analysis of adipogenesis using reverse transfection technology and time-lapse video microscopy by Grönniger, Elke, Wessel, Sonja, Kühn, Sonja Christin, Söhle, Jörn, Wenck, Horst, Stäb, Franz, Winnefeld, Marc

“…Since the worldwide increase in obesity represents a growing challenge for healthcare systems, research focusing on fat cell metabolism has become a focal…”
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Targeting epigenetic age to prevent cancer by Winnefeld, Marc, Lyko, Frank

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Modeling transcriptomic age using knowledge-primed artificial neural networks by Holzscheck, Nicholas, Falckenhayn, Cassandra, Söhle, Jörn, Kristof, Boris, Siegner, Ralf, Werner, André, Schössow, Janka, Jürgens, Clemens, Völzke, Henry, Wenck, Horst, Winnefeld, Marc, Grönniger, Elke, Kaderali, Lars

“…The development of ‘age clocks’, machine learning models predicting age from biological data, has been a major milestone in the search for reliable markers of…”
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An integrative metabolomics and transcriptomics study to identify metabolic alterations in aged skin of humans in vivo by Kuehne, Andreas, Hildebrand, Janosch, Soehle, Joern, Wenck, Horst, Terstegen, Lara, Gallinat, Stefan, Knott, Anja, Winnefeld, Marc, Zamboni, Nicola

“…Aging human skin undergoes significant morphological and functional changes such as wrinkle formation, reduced wound healing capacity, and altered epidermal…”
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Macrophages Are Polarized toward an Inflammatory Phenotype by their Aged Microenvironment in the Human Skin by Gather, Leonie, Nath, Neetika, Falckenhayn, Cassandra, Oterino-Sogo, Sergio, Bosch, Thomas, Wenck, Horst, Winnefeld, Marc, Grönniger, Elke, Simm, Stefan, Siracusa, Annette

“…Aging of the skin is accompanied by cellular as well as tissue environmental changes, ultimately reducing the ability of the tissue to regenerate and…”
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Cohort Profile Update: The Study of Health in Pomerania (SHIP) by Völzke, Henry, Schössow, Janka, Schmidt, Carsten Oliver, Jürgens, Clemens, Richter, Adrian, Werner, André, Werner, Nicole, Radke, Dörte, Teumer, Alexander, Ittermann, Till, Schauer, Birgit, Henck, Vivien, Friedrich, Nele, Hannemann, Anke, Winter, Theresa, Nauck, Matthias, Dörr, Marcus, Bahls, Martin, Felix, Stephan B, Stubbe, Beate, Ewert, Ralf, Frost, Fabian, Lerch, Markus M, Grabe, Hans J, Bülow, Robin, Otto, Markus, Hosten, Norbert, Rathmann, Wolfgang, Schminke, Ulf, Großjohann, Rico, Tost, Frank, Homuth, Georg, Völker, Uwe, Weiss, Stefan, Holtfreter, Silva, Bröker, Barbara M, Zimmermann, Kathrin, Kaderali, Lars, Winnefeld, Marc, Kristof, Boris, Berger, Klaus, Samietz, Stefanie, Schwahn, Christian, Holtfreter, Birte, Biffar, Reiner, Kindler, Stefan, Wittfeld, Katharina, Hoffmann, Wolfgang, Kocher, Thomas

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Reduced DNA methylation patterning and transcriptional connectivity define human skin aging by Bormann, Felix, Rodríguez‐Paredes, Manuel, Hagemann, Sabine, Manchanda, Himanshu, Kristof, Boris, Gutekunst, Julian, Raddatz, Günter, Haas, Rainer, Terstegen, Lara, Wenck, Horst, Kaderali, Lars, Winnefeld, Marc, Lyko, Frank

“…Summary Epigenetic changes represent an attractive mechanism for understanding the phenotypic changes associated with human aging. Age‐related changes in DNA…”
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Multi-omics network analysis reveals distinct stages in the human aging progression in epidermal tissue by Holzscheck, Nicholas, Söhle, Jörn, Kristof, Boris, Grönniger, Elke, Gallinat, Stefan, Wenck, Horst, Winnefeld, Marc, Falckenhayn, Cassandra, Kaderali, Lars

“…In recent years, reports of non-linear regulations in age- and longevity-associated biological processes have been accumulating. Inspired by methodological…”
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