Search Results - "Winnay, J N"

A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes by Mauvais-Jarvis, F, Virkamaki, A, Michael, M D, Winnay, J N, Zisman, A, Kulkarni, R N, Kahn, C R

“…A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes. F Mauvais-Jarvis , A…”
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Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes by Kulkarni, Rohit N, Brüning, Jens C, Winnay, Jonathon N, Postic, Catherine, Magnuson, Mark A, Kahn, C.Ronald

“…Dysfunction of the pancreatic β cell is an important defect in the pathogenesis of type 2 diabetes, although its exact relationship to the insulin resistance…”
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A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance by Brüning, Jens C, Michael, M.Dodson, Winnay, Jonathon N, Hayashi, Tatsuya, Hörsch, Dieter, Accili, Domenico, Goodyear, Laurie J, Kahn, C.Ronald

“…Skeletal muscle insulin resistance is among the earliest detectable defects in humans with type 2 diabetes mellitus. To determine the contribution of muscle…”
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Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines by Kulkarni, R N, Winnay, J N, Daniels, M, Brüning, J C, Flier, S N, Hanahan, D, Kahn, C R

“…Insulin receptor substrate-1 (IRS-1) is pivotal in mediating the actions of insulin and growth factors in most tissues of the body, but its role in…”
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Convergence of Wnt Signaling and Steroidogenic Factor-1 (SF-1) on Transcription of the Rat Inhibin α Gene by Gummow, Brian M., Winnay, Jonathon N., Hammer, Gary D.

“…The action of a variety of peptide hormones is critical for proper growth and differentiation of the urogenital ridge, which ultimately gives rise to the…”
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Gab-1-mediated IGF-1 Signaling in IRS-1-deficient 3T3 Fibroblasts by Winnay, Jonathon N., Brüning, Jens C., Burks, Deborah J., Kahn, C.Ronald

“…The insulin receptor substrate (IRS) family of proteins mediate a variety of intracellular signaling events by serving as signaling platforms downstream of…”
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PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance by Kulkarni, Rohit N., Jhala, Ulupi S., Winnay, Jonathon N., Krajewski, Stan, Montminy, Marc, Kahn, C. Ronald

“…Inadequate compensatory β cell hyperplasia in insulin-resistant states triggers the development of overt diabetes. The mechanisms that underlie this crucial…”
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Adrenocorticotropic Hormone-Mediated Signaling Cascades Coordinate a Cyclic Pattern of Steroidogenic Factor 1-Dependent Transcriptional Activation by Winnay, Jonathon N, Hammer, Gary D

“…Steroidogenic factor 1 (SF-1) is an orphan nuclear receptor that has emerged as a critical mediator of endocrine function at multiple levels of the…”
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Phosphorylation of C/EBPα Inhibits Granulopoiesis by Ross, Sarah E., Radomska, Hanna S., Wu, Bo, Zhang, Pu, Winnay, Jonathon N., Bajnok, Laszlo, Wright, Wendy S., Schaufele, Fred, Tenen, Daniel G., MacDougald, Ormond A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Steroid Receptor Coactivator-1-Deficient Mice Exhibit Altered Hypothalamic-Pituitary-Adrenal Axis Function by Winnay, Jonathon N, Xu, Jianming, O’Malley, Bert W, Hammer, Gary D

“…Steroidogenic factor-1 (SF-1), has emerged as a critical nuclear receptor regulating development and differentiation at several levels of the…”
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Impact of Genetic Background on Development of Hyperinsulinemia and Diabetes in Insulin Receptor/Insulin Receptor Substrate-1 Double Heterozygous Mice by KULKARNI, Rohit N, ALMIND, Katrine, GOREN, H. Joseph, WINNAY, Jonathon N, UEKI, Kohjiro, OKADA, Terumasa, KAHN, C. Ronald

“…Impact of Genetic Background on Development of Hyperinsulinemia and Diabetes in Insulin Receptor/Insulin Receptor Substrate-1 Double Heterozygous Mice Rohit N…”
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