Search Results - "Winkler, Thomas W"

Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals by Stanzick, Kira J., Li, Yong, Schlosser, Pascal, Gorski, Mathias, Wuttke, Matthias, Thomas, Laurent F., Rasheed, Humaira, Rowan, Bryce X., Graham, Sarah E., Vanderweff, Brett R., Patil, Snehal B., Robinson-Cohen, Cassiane, Gaziano, John M., O’Donnell, Christopher J., Willer, Cristen J., Hallan, Stein, Åsvold, Bjørn Olav, Gessner, Andre, Hung, Adriana M., Pattaro, Cristian, Köttgen, Anna, Stark, Klaus J., Heid, Iris M., Winkler, Thomas W.

“…Genes underneath signals from genome-wide association studies (GWAS) for kidney function are promising targets for functional studies, but prioritizing…”
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Effect of 25-hydroxyvitamin D levels on the internalising dimension as a transdiagnostic risk factor: Mendelian randomisation study by Konzok, Julian, Baumeister, Sebastian-Edgar, Winkler, Thomas W., Leitzmann, Michael F., Baurecht, Hansjörg

“…Observational studies indicate a relationship between vitamin D (25-hydroxyvitamin D; 25OHD) deficiency and the development of internalising disorders,…”
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EasyStrata: evaluation and visualization of stratified genome-wide association meta-analysis data by Winkler, Thomas W, Kutalik, Zoltan, Gorski, Mathias, Lottaz, Claudio, Kronenberg, Florian, Heid, Iris M

“…The R package EasyStrata facilitates the evaluation and visualization of stratified genome-wide association meta-analyses (GWAMAs) results. It provides (i)…”
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A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications by Winkler, Thomas W, Günther, Felix, Höllerer, Simon, Zimmermann, Martina, Loos, Ruth JF, Kutalik, Zoltán, Heid, Iris M

“…The problem of the genetics of related phenotypes is often addressed by analyzing adjusted-model traits, but such traits warrant cautious interpretation. Here,…”
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KidneyGPS: a user-friendly web application to help prioritize kidney function genes and variants based on evidence from genome-wide association studies by Stanzick, Kira J, Stark, Klaus J, Gorski, Mathias, Schödel, Johannes, Krüger, René, Kronenberg, Florian, Warth, Richard, Heid, Iris M, Winkler, Thomas W

“…Abstract Background Genome-wide association studies (GWAS) have identified hundreds of genetic loci associated with kidney function. By combining these…”
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Genome wide association study and genomic risk prediction of age related macular degeneration in Israel by Grunin, Michelle, Triffon, Daria, Beykin, Gala, Rahmani, Elior, Schweiger, Regev, Tiosano, Liran, Khateb, Samer, Hagbi-Levi, Shira, Rinsky, Batya, Munitz, Refael, Winkler, Thomas W., Heid, Iris M., Halperin, Eran, Carmi, Shai, Chowers, Itay

“…The risk of developing age-related macular degeneration (AMD) is influenced by genetic background. In 2016, the International AMD Genomics Consortium (IAMDGC)…”
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Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease by Winkler, Thomas W, Grassmann, Felix, Brandl, Caroline, Kiel, Christina, Günther, Felix, Strunz, Tobias, Weidner, Lorraine, Zimmermann, Martina E, Korb, Christina A, Poplawski, Alicia, Schuster, Alexander K, Müller-Nurasyid, Martina, Peters, Annette, Rauscher, Franziska G, Elze, Tobias, Horn, Katrin, Scholz, Markus, Cañadas-Garre, Marisa, McKnight, Amy Jayne, Quinn, Nicola, Hogg, Ruth E, Küchenhoff, Helmut, Heid, Iris M, Stark, Klaus J, Weber, Bernhard H F

“…Advanced age-related macular degeneration (AMD) is a leading cause of blindness. While around half of the genetic contribution to advanced AMD has been…”
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Approaches to detect genetic effects that differ between two strata in genome-wide meta-analyses: Recommendations based on a systematic evaluation by Winkler, Thomas W, Justice, Anne E, Cupples, L Adrienne, Kronenberg, Florian, Kutalik, Zoltán, Heid, Iris M

“…Genome-wide association meta-analyses (GWAMAs) conducted separately by two strata have identified differences in genetic effects between strata, such as…”
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Investigating the modulation of genetic effects on late AMD by age and sex: Lessons learned and two additional loci by Winkler, Thomas W, Brandl, Caroline, Grassmann, Felix, Gorski, Mathias, Stark, Klaus, Loss, Julika, Weber, Bernhard H F, Heid, Iris M

“…Late-stage age-related macular degeneration (AMD) is the leading cause of visual impairment in the elderly with a complex etiology. The most important…”
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Addendum: A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications by Winkler, Thomas W, Günther, Felix, Höllerer, Simon, Zimmermann, Martina, Loos, Ruth JF, Kutalik, Zoltán, Heid, Iris M

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The role of genetic variation of human metabolism for BMI, mental traits and mental disorders by Hebebrand, Johannes, Peters, Triinu, Schijven, Dick, Hebebrand, Moritz, Grasemann, Corinna, Winkler, Thomas W., Heid, Iris M., Antel, Jochen, Föcker, Manuel, Tegeler, Lisa, Brauner, Lena, Adan, Roger A.H., Luykx, Jurjen J., Correll, Christoph U., König, Inke R., Hinney, Anke, Libuda, Lars

“…The aim was to assess whether loci associated with metabolic traits also have a significant role in BMI and mental traits/disorders We first assessed the…”
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Polygenic scores for estimated glomerular filtration rate in a population of general adults and elderly - comparative results from the KORA and AugUR study by Herold, Janina M, Nano, Jana, Gorski, Mathias, Winkler, Thomas W, Stanzick, Kira J, Zimmermann, Martina E, Brandl, Caroline, Peters, Annette, Koenig, Wolfgang, Burkhardt, Ralph, Gessner, André, Heid, Iris M, Gieger, Christian, Stark, Klaus J

“…Polygenic scores (PGSs) combining genetic variants found to be associated with creatinine-based estimated glomerular filtration rate (eGFR ) have been applied…”
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Incidence, progression and risk factors of age-related macular degeneration in 35–95-year-old individuals from three jointly designed German cohort studies by Brandl, Caroline, Günther, Felix, Zimmermann, Martina E, Hartmann, Kathrin I, Eberlein, Gregor, Barth, Teresa, Winkler, Thomas W, Linkohr, Birgit, Heier, Margit, Peters, Annette, Li, Jeany Q, Finger, Robert P, Helbig, Horst, Weber, Bernhard H F, Küchenhoff, Helmut, Mueller, Arthur, Stark, Klaus J, Heid, Iris M

“…ObjectiveTo estimate age-related macular degeneration (AMD) incidence/progression across a wide age range.Methods and analysisAMD at baseline and follow-up…”
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Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry by Pulit, Sara L, Stoneman, Charli, Morris, Andrew P, Wood, Andrew R, Glastonbury, Craig A, Tyrrell, Jessica, Yengo, Loïc, Ferreira, Teresa, Marouli, Eirini, Ji, Yingjie, Yang, Jian, Jones, Samuel, Beaumont, Robin, Croteau-Chonka, Damien C, Winkler, Thomas W, Hattersley, Andrew T, Loos, Ruth J F, Hirschhorn, Joel N, Visscher, Peter M, Frayling, Timothy M, Yaghootkar, Hanieh, Lindgren, Cecilia M

“…Abstract More than one in three adults worldwide is either overweight or obese. Epidemiological studies indicate that the location and distribution of excess…”
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418-P: Allometric Body Shape Indices, T2D, and Kidney Function—A Two-Sample Mendelian Randomization Study by KJAERGAARD, ALISA D., KRAKAUER, JESSE, KRAKAUER, NIR, TEUMER, ALEXANDER, WINKLER, THOMAS W., ELLERVIK, CHRISTINA

“…In a two-sample Mendelian randomization (MR) analysis, using summary statistics from UK Biobank, CKDGen and DIAGRAM, we examined the association between BMI…”
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Obesity and Kidney Function: A Two-Sample Mendelian Randomization Study by Kjaergaard, Alisa D, Teumer, Alexander, Witte, Daniel R, Stanzick, Kira-Julia, Winkler, Thomas W, Burgess, Stephen, Ellervik, Christina

“…Abstract Background Obesity and type 2 diabetes (T2D) are correlated risk factors for chronic kidney disease (CKD). Methods Using summary data from GIANT…”
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Child maltreatment as a transdiagnostic risk factor for the externalizing dimension: a Mendelian randomization study by Konzok, Julian, Gorski, Mathias, Winkler, Thomas W, Baumeister, Sebastian E, Warrier, Varun, Leitzmann, Michael F, Baurecht, Hansjörg

“…Observational studies suggest that child maltreatment increases the risk of externalizing spectrum disorders such as attention deficit hyperactivity disorder…”
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Allometric body shape indices, type 2 diabetes and kidney function: A two‐sample Mendelian randomization study by Kjaergaard, Alisa D., Krakauer, Jesse, Krakauer, Nir, Teumer, Alexander, Winkler, Thomas W., Ellervik, Christina

“…Aim To examine the association between body mass index (BMI)‐independent allometric body shape indices and kidney function. Materials and methods We performed…”
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Quality control and conduct of genome-wide association meta-analyses by Winkler, Thomas W, Day, Felix R, Croteau-Chonka, Damien C, Wood, Andrew R, Locke, Adam E, Mägi, Reedik, Ferreira, Teresa, Fall, Tove, Graff, Mariaelisa, Justice, Anne E, Luan, Jian'an, Gustafsson, Stefan, Randall, Joshua C, Vedantam, Sailaja, Workalemahu, Tsegaselassie, Kilpeläinen, Tuomas O, Scherag, André, Esko, Tonu, Kutalik, Zoltán, Heid, Iris M, Loos, Ruth J F

“…A protocol providing guidelines on the organizational aspects of genome-wide association meta-analyses and to implement quality control at the study file…”
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Heterogeneity in Obesity: Genetic Basis and Metabolic Consequences by Sulc, Jonathan, Winkler, Thomas W., Heid, Iris M., Kutalik, Zoltán

“…Purpose of Review Our review provides a brief summary of the most recent advances towards the identification of the genetic basis of specific aspects of…”
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